ANAB vs. AMD

Last updated Apr 1, 2026

Compare and contrast key facts about AnaptysBio, Inc. (ANAB) and Advanced Micro Devices, Inc. (AMD).

Performance

ANAB vs. AMD - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AnaptysBio, Inc. (ANAB) and Advanced Micro Devices, Inc. (AMD). The values are adjusted to include any dividend payments, if applicable.

ANAB vs. AMD - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ANAB AnaptysBio, Inc.	14.40%	266.16%	-38.19%	-30.88%	-10.82%	61.63%	32.31%	-74.53%	-36.67%	492.47%
AMD Advanced Micro Devices, Inc.	-5.01%	77.30%	-18.06%	127.59%	-54.99%	56.91%	99.98%	148.43%	79.57%	-2.28%

Fundamentals

Market Cap ANAB : $1.74B AMD : $335.46B
EPS ANAB : -$0.45 AMD : $2.64
PS Ratio ANAB : 7.03 AMD : 9.63
PB Ratio ANAB : 46.72 AMD : 5.32
Total Revenue (TTM) ANAB : $234.60M AMD : $34.64B
Gross Profit (TTM) ANAB : -$27.77M AMD : $17.15B
EBITDA (TTM) ANAB : $47.90M AMD : $6.18B

Returns By Period

In the year-to-date period, ANAB achieves a 14.40% return, which is significantly higher than AMD's -5.01% return.

ANAB

• 1D: 0.13%
• 1M: 0.74%
• YTD: 14.40%
• 6M: 81.12%
• 1Y: 198.33%
• 3Y*: 36.60%
• 5Y*: 20.54%
• 10Y*: —

AMD

• 1D: 3.77%
• 1M: 1.61%
• YTD: -5.01%
• 6M: 25.74%
• 1Y: 98.00%
• 3Y*: 27.56%
• 5Y*: 20.20%
• 10Y*: 53.34%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

ANAB vs. AMD — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ANAB

ANAB Risk / Return Rank: 95
ANAB Sharpe Ratio Rank: 96
ANAB Sortino Ratio Rank: 94
ANAB Omega Ratio Rank: 93
ANAB Calmar Ratio Rank: 96
ANAB Martin Ratio Rank: 96

AMD

AMD Risk / Return Rank: 85
AMD Sharpe Ratio Rank: 85
AMD Sortino Ratio Rank: 84
AMD Omega Ratio Rank: 83
AMD Calmar Ratio Rank: 89
AMD Martin Ratio Rank: 84

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ANAB vs. AMD - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AnaptysBio, Inc. (ANAB) and Advanced Micro Devices, Inc. (AMD). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ANAB	AMD	Difference
Sharpe ratio Return per unit of total volatility	2.97	1.52	+1.45
Sortino ratio Return per unit of downside risk	3.40	2.31	+1.09
Omega ratio Gain probability vs. loss probability	1.45	1.30	+0.15
Calmar ratio Return relative to maximum drawdown	6.84	3.50	+3.35
Martin ratio Return relative to average drawdown	18.63	7.16	+11.47
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ANAB vs. AMD - Sharpe Ratio Comparison

The current ANAB Sharpe Ratio is 2.97, which is higher than the AMD Sharpe Ratio of 1.52. The chart below compares the historical Sharpe Ratios of ANAB and AMD, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	ANAB	AMD	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.97	1.52	+1.45
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.32	0.38	-0.06
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.91	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.18	0.13	+0.06

Correlation

The correlation between ANAB and AMD is 0.21, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

ANAB vs. AMD - Dividend Comparison

Neither ANAB nor AMD has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

ANAB vs. AMD - Drawdown Comparison

The maximum ANAB drawdown since its inception was -92.08%, roughly equal to the maximum AMD drawdown of -96.59%. Use the drawdown chart below to compare losses from any high point for ANAB and AMD.

Drawdown Indicators

	ANAB	AMD	Difference
Max Drawdown Largest peak-to-trough decline	-92.08%	-96.59%	+4.51%
Max Drawdown (1Y) Largest decline over 1 year	-28.15%	-27.76%	-0.39%
Max Drawdown (5Y) Largest decline over 5 years	-69.32%	-65.45%	-3.87%
Max Drawdown (10Y) Largest decline over 10 years	—	-65.45%	—
Current Drawdown Current decline from peak	-56.86%	-23.04%	-33.82%
Average Drawdown Average peak-to-trough decline	-65.31%	-56.90%	-8.41%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.34%	13.56%	-3.22%

Volatility

ANAB vs. AMD - Volatility Comparison

AnaptysBio, Inc. (ANAB) has a higher volatility of 24.24% compared to Advanced Micro Devices, Inc. (AMD) at 16.50%. This indicates that ANAB's price experiences larger fluctuations and is considered to be riskier than AMD based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ANAB	AMD	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.24%	16.50%	+7.74%
Volatility (6M) Calculated over the trailing 6-month period	50.81%	49.06%	+1.75%
Volatility (1Y) Calculated over the trailing 1-year period	67.28%	64.69%	+2.59%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	64.31%	53.46%	+10.85%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	75.52%	58.64%	+16.88%

Financials

ANAB vs. AMD - Profitability Comparison

The chart below illustrates the profitability comparison between AnaptysBio, Inc. and Advanced Micro Devices, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

ANAB - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, AnaptysBio, Inc. reported a gross profit of -43.71M and revenue of 108.25M. Therefore, the gross margin over that period was -40.4%.

AMD - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Advanced Micro Devices, Inc. reported a gross profit of 5.58B and revenue of 10.27B. Therefore, the gross margin over that period was 54.3%.

ANAB - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, AnaptysBio, Inc. reported an operating income of 66.90M and revenue of 108.25M, resulting in an operating margin of 61.8%.

AMD - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Advanced Micro Devices, Inc. reported an operating income of 1.75B and revenue of 10.27B, resulting in an operating margin of 17.1%.

ANAB - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, AnaptysBio, Inc. reported a net income of 49.61M and revenue of 108.25M, resulting in a net margin of 45.8%.

AMD - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Advanced Micro Devices, Inc. reported a net income of 1.51B and revenue of 10.27B, resulting in a net margin of 14.7%.