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Vertex Pharmaceuticals Incorporated (VRTX)
Performance
Return for Risk
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN
US92532F1003
CUSIP
92532F100
IPO Date
Jul 24, 1991

Highlights

Market Cap
$114.36B
Enterprise Value
$112.97B
EPS (TTM)
$15.35
PE Ratio
29.09
PEG Ratio
2.42
Total Revenue (TTM)
$12.00B
Gross Profit (TTM)
$10.35B
EBITDA (TTM)
$4.74B
Year Range
$362.50 - $510.77
Target Price
$547.82
ROA (TTM)
15.42%
ROE (TTM)
21.18%

Share Price Chart


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Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Vertex Pharmaceuticals Incorporated, comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


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S&P 500 Index

Returns By Period

Vertex Pharmaceuticals Incorporated (VRTX) has returned -1.50% so far this year and -7.90% over the past 12 months. Looking at the last ten years, VRTX has achieved an annualized return of 18.89%, outperforming the S&P 500 Index benchmark, which averaged 12.16% per year.


Vertex Pharmaceuticals Incorporated

1D
0.76%
1M
-10.12%
YTD
-1.50%
6M
14.02%
1Y
-7.90%
3Y*
12.33%
5Y*
15.95%
10Y*
18.89%

Benchmark (S&P 500 Index)

1D
2.91%
1M
-5.09%
YTD
-4.63%
6M
-2.39%
1Y
16.33%
3Y*
16.69%
5Y*
10.18%
10Y*
12.16%
*Multi-year figures are annualized to reflect compound growth (CAGR)

Monthly Returns

Based on dividend-adjusted daily data since Jul 24, 1991, VRTX's average daily return is +0.11%, while the average monthly return is +2.18%. At this rate, your investment would double in approximately 2.7 years.

Historically, 54% of months were positive and 46% were negative. The best month was Feb 2000 with a return of +77.2%, while the worst month was Sep 2001 at -51.1%. The longest winning streak lasted 8 consecutive months, and the longest losing streak was 7 months.

On a daily basis, VRTX closed higher 48% of trading days. The best single day was Apr 19, 2013 with a return of +61.9%, while the worst single day was Nov 11, 2003 at -36.8%.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
20263.65%5.73%-10.12%-1.50%
202514.65%3.92%1.05%5.09%-13.24%0.71%2.62%-14.41%0.16%8.66%1.89%4.55%12.58%
20246.51%-2.92%-0.65%-6.03%15.92%2.94%5.76%0.03%-6.21%2.34%-1.65%-13.98%-1.03%
202311.88%-10.15%8.54%8.14%-5.04%8.76%0.12%-1.14%-0.17%4.13%-2.02%14.68%40.90%
202210.68%-5.36%13.46%4.69%-1.67%4.89%-0.49%0.48%2.76%7.76%1.41%-8.73%31.50%
2021-3.07%-7.22%1.10%1.54%-4.39%-3.36%-0.02%-0.64%-9.44%1.95%1.09%17.47%-7.08%

Benchmark Metrics

Vertex Pharmaceuticals Incorporated has an annualized alpha of 19.08%, beta of 1.07, and R² of 0.12 versus S&P 500 Index. Calculated based on daily prices since July 25, 1991.

  • This stock captured 131.66% of S&P 500 Index gains and 105.46% of its losses — amplifying both gains and losses, but participating more in upside than downside.
  • R² of 0.12 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

Alpha
19.08%
Beta
1.07
0.12
Upside Capture
131.66%
Downside Capture
105.46%

Return for Risk

Risk / Return Rank

VRTX ranks 29 for risk / return — below 29% of stocks on our site. The returns aren't fully compensating for the risk involved. This isn't necessarily a dealbreaker, but factor it into your decision — especially if you're risk-averse.


VRTX Risk / Return Rank: 2929
Overall Rank
VRTX Sharpe Ratio Rank: 3030
Sharpe Ratio Rank
VRTX Sortino Ratio Rank: 2727
Sortino Ratio Rank
VRTX Omega Ratio Rank: 2727
Omega Ratio Rank
VRTX Calmar Ratio Rank: 3030
Calmar Ratio Rank
VRTX Martin Ratio Rank: 3030
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

Return / Risk — by metrics

The table below present risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and compare them to a chosen benchmark (S&P 500 Index).


VRTXBenchmarkDifference

Sharpe ratio

Return per unit of total volatility

-0.22

0.90

-1.12

Sortino ratio

Return per unit of downside risk

-0.05

1.39

-1.44

Omega ratio

Gain probability vs. loss probability

0.99

1.21

-0.22

Calmar ratio

Return relative to maximum drawdown

-0.33

1.40

-1.73

Martin ratio

Return relative to average drawdown

-0.65

6.61

-7.26

Explore VRTX risk-adjusted metrics in detail

Dive deeper into individual metrics with historical trends, benchmark comparisons, and performance across different time periods.

Dividends

Dividend History


Vertex Pharmaceuticals Incorporated doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Vertex Pharmaceuticals Incorporated. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Vertex Pharmaceuticals Incorporated was 91.77%, occurring on Nov 11, 2003. Recovery took 2677 trading sessions.

The current Vertex Pharmaceuticals Incorporated drawdown is 13.59%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-91.77%Nov 3, 2000757Nov 11, 20032677Jul 2, 20143434
-70.17%Feb 25, 1997383Aug 31, 1998363Feb 8, 2000746
-60.87%Jan 7, 1992115Jun 18, 1992335Oct 14, 1993450
-55.25%Mar 7, 200029Apr 14, 200043Jun 16, 200072
-49.1%Aug 20, 2015340Dec 22, 2016142Jul 19, 2017482

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Vertex Pharmaceuticals Incorporated over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Valuation

The Valuation section provides an overview of how Vertex Pharmaceuticals Incorporated is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PE Ratio

The chart displays the Price-to-Earnings (P/E) ratio for VRTX, comparing it with other companies in the Biotechnology industry. Currently, VRTX has a P/E ratio of 29.1. This P/E ratio is in line with the industry average, suggesting the stock may be fairly valued relative to its earnings.

PEG Ratio

The chart shows the Price/Earnings to Growth (PEG) ratio for VRTX compared to other companies in the Biotechnology industry. VRTX currently has a PEG ratio of 2.4. This PEG ratio is higher than the industry average, which may suggest the stock is overvalued relative to its expected earnings growth.

PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for VRTX relative to other companies in the Biotechnology industry. Currently, VRTX has a P/S ratio of 9.6. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for VRTX in comparison with other companies in the Biotechnology industry. Currently, VRTX has a P/B value of 6.1. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items