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Vertex Pharmaceuticals Incorporated (VRTX)
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN

US92532F1003

CUSIP

92532F100

IPO Date

Jul 24, 1991

Highlights

Market Cap

$111.55B

EPS (TTM)

-$3.83

PEG Ratio

2.59

Total Revenue (TTM)

$11.09B

Gross Profit (TTM)

$9.54B

EBITDA (TTM)

-$228.00M

Year Range

$377.85 - $519.88

Target Price

$500.30

Short %

1.66%

Short Ratio

2.24

Share Price Chart


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Compare to other instruments

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Performance

Performance Chart


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Returns By Period

Vertex Pharmaceuticals Incorporated (VRTX) returned 8.93% year-to-date (YTD) and -0.45% over the past 12 months. Over the past 10 years, VRTX delivered an annualized return of 13.11%, outperforming the S&P 500 benchmark at 10.87%.


VRTX

YTD

8.93%

1M

-9.72%

6M

-5.81%

1Y

-0.45%

5Y*

8.75%

10Y*

13.11%

^GSPC (Benchmark)

YTD

1.30%

1M

12.94%

6M

1.49%

1Y

12.48%

5Y*

15.82%

10Y*

10.87%

*Annualized

Monthly Returns

The table below presents the monthly returns of VRTX, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
202514.65%3.92%1.05%5.09%-13.91%8.93%
20246.51%-2.92%-0.65%-6.03%15.92%2.94%5.76%0.03%-6.21%2.34%-1.65%-13.98%-1.03%
202311.88%-10.15%8.54%8.14%-5.04%8.76%0.12%-1.14%-0.17%4.13%-2.02%14.68%40.90%
202210.68%-5.36%13.46%4.69%-1.67%4.89%-0.49%0.48%2.76%7.76%1.41%-8.73%31.50%
2021-3.07%-7.22%1.10%1.54%-4.39%-3.36%-0.02%-0.64%-9.44%1.95%1.09%17.47%-7.08%
20203.70%-1.33%6.21%5.57%14.63%0.82%-6.31%2.62%-2.51%-23.43%9.31%3.77%7.94%
201915.21%-1.13%-2.54%-8.14%-1.66%10.35%-9.14%8.04%-5.89%15.38%13.44%-1.26%32.13%
201811.35%-0.50%-1.84%-6.03%0.55%10.36%2.99%5.34%4.52%-12.08%6.69%-8.34%10.58%
201716.56%5.53%20.67%8.18%4.48%4.26%17.81%5.74%-5.29%-3.82%-1.33%3.86%103.42%
2016-27.88%-5.80%-7.02%6.10%10.45%-7.65%12.76%-2.57%-7.72%-13.01%7.58%-9.73%-41.45%
2015-7.29%8.43%-1.22%4.50%4.06%-3.75%9.33%-5.54%-18.33%19.78%3.70%-2.73%5.92%
20146.38%2.30%-12.54%-4.27%6.74%31.03%-6.09%5.24%20.03%0.29%4.65%0.78%59.89%

Risk-Adjusted Performance

Risk-Adjusted Performance Rank

The current rank of VRTX is 50, indicating average performance compared to other stocks on our website. Here’s a breakdown of how it compares using common performance measures.


The Risk-Adjusted Performance Rank of VRTX is 5050
Overall Rank
The Sharpe Ratio Rank of VRTX is 5050
Sharpe Ratio Rank
The Sortino Ratio Rank of VRTX is 4444
Sortino Ratio Rank
The Omega Ratio Rank of VRTX is 4545
Omega Ratio Rank
The Calmar Ratio Rank of VRTX is 5656
Calmar Ratio Rank
The Martin Ratio Rank of VRTX is 5555
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

Risk-Adjusted Performance Indicators

The charts below present risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.


The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

Vertex Pharmaceuticals Incorporated Sharpe ratios as of May 17, 2025 (values are recalculated daily):

  • 1-Year: -0.02
  • 5-Year: 0.30
  • 10-Year: 0.38
  • All Time: 0.26

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns (including price changes and dividends).

The chart below shows the rolling Sharpe ratio of Vertex Pharmaceuticals Incorporated compared to the selected benchmark. This view highlights how the investment's risk-adjusted performance has changed over time. For deeper analysis or to customize the calculation, use the Sharpe ratio tool.


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Dividends

Dividend History


Vertex Pharmaceuticals Incorporated doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Vertex Pharmaceuticals Incorporated. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Vertex Pharmaceuticals Incorporated was 91.77%, occurring on Nov 11, 2003. Recovery took 2676 trading sessions.

The current Vertex Pharmaceuticals Incorporated drawdown is 15.11%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-91.77%Nov 3, 2000757Nov 11, 20032676Jul 2, 20143433
-70.17%Feb 25, 1997383Aug 31, 1998363Feb 8, 2000746
-60.87%Jan 7, 1992114Jun 18, 1992335Oct 14, 1993449
-55.26%Mar 7, 200029Apr 14, 200043Jun 16, 200072
-49.1%Aug 20, 2015340Dec 22, 2016142Jul 19, 2017482

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Vertex Pharmaceuticals Incorporated over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Earnings Per Share

The chart presents the Earnings Per Share (EPS) performance of Vertex Pharmaceuticals Incorporated, comparing actual results with analytics estimates. In the past quarter, the company did not meet analyst expectations for EPS, resulting in a surprise of -5.4%.


-10.00-5.000.005.0020212022202320242025
4.06
4.29
Actual
Estimate

Valuation

The Valuation section provides an overview of how Vertex Pharmaceuticals Incorporated is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PEG Ratio

The chart shows the Price/Earnings to Growth (PEG) ratio for VRTX compared to other companies in the Biotechnology industry. VRTX currently has a PEG ratio of 2.6. This PEG ratio is close to the industry average, suggesting the stock’s valuation is balanced against its growth outlook.

PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for VRTX relative to other companies in the Biotechnology industry. Currently, VRTX has a P/S ratio of 10.0. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for VRTX in comparison with other companies in the Biotechnology industry. Currently, VRTX has a P/B value of 6.8. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items