VRTX vs. LNTH
VRTX (Vertex Pharmaceuticals Incorporated) and LNTH (Lantheus Holdings, Inc.) are both stocks. Both are in the Healthcare sector — VRTX in Biotechnology, LNTH in Diagnostics & Research. Over the past 10 years, VRTX returned 16.38%/yr vs 46.44%/yr for LNTH. At a 0.24 correlation, their price movements are largely independent.
Performance
VRTX vs. LNTH - Performance Comparison
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Returns By Period
In the year-to-date period, VRTX achieves a -5.52% return, which is significantly lower than LNTH's 50.64% return. Over the past 10 years, VRTX has underperformed LNTH with an annualized return of 16.38%, while LNTH has yielded a comparatively higher 46.44% annualized return.
VRTX
- 1D
- 0.76%
- 1M
- -0.35%
- YTD
- -5.52%
- 6M
- -7.51%
- 1Y
- -4.06%
- 3Y*
- 8.67%
- 5Y*
- 15.33%
- 10Y*
- 16.38%
LNTH
- 1D
- 4.10%
- 1M
- 14.21%
- YTD
- 50.64%
- 6M
- 67.73%
- 1Y
- 29.04%
- 3Y*
- 4.18%
- 5Y*
- 32.45%
- 10Y*
- 46.44%
VRTX vs. LNTH - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
VRTX Vertex Pharmaceuticals Incorporated | -5.52% | 12.58% | -1.03% | 40.90% | 31.50% | -7.08% | 7.94% | 32.13% | 10.58% | 103.42% |
LNTH Lantheus Holdings, Inc. | 50.64% | -25.61% | 44.29% | 21.66% | 76.39% | 114.16% | -34.23% | 31.05% | -23.47% | 137.79% |
Correlation
The correlation between VRTX and LNTH is 0.20, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.20 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.18 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.24 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.24 |
Correlation (All Time) Calculated using the full available price history since Jun 26, 2015 | 0.24 |
Fundamentals
VRTX:
$109.78B
LNTH:
$6.59B
VRTX:
$16.87
LNTH:
$4.13
VRTX:
25.40
LNTH:
24.26
VRTX:
2.11
LNTH:
0.10
VRTX:
8.99
LNTH:
4.38
VRTX:
4.15
LNTH:
5.44
VRTX:
$12.26B
LNTH:
$1.55B
VRTX:
$10.57B
LNTH:
$935.17M
VRTX:
$5.19B
LNTH:
$369.99M
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Return for Risk
VRTX vs. LNTH — Risk / Return Rank
VRTX
LNTH
VRTX vs. LNTH - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and Lantheus Holdings, Inc. (LNTH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| VRTX | LNTH | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.74 | ||
| Sortino ratioReturn per unit of downside risk | -0.95 | ||
| Omega ratioGain probability vs. loss probability | 1.01 | 1.17 | -0.16 |
| Calmar ratioReturn relative to maximum drawdown | -0.17 | 0.73 | -0.90 |
| Martin ratioReturn relative to average drawdown | -0.37 | 1.28 | -1.64 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| VRTX | LNTH | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.12 | 0.62 | -0.74 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.53 | 0.57 | -0.04 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.50 | 0.75 | -0.25 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.25 | 0.43 | -0.18 |
Drawdowns
VRTX vs. LNTH - Drawdown Comparison
The maximum VRTX drawdown since its inception was -91.77%, which is greater than LNTH's maximum drawdown of -78.62%. Use the drawdown chart below to compare losses from any high point for VRTX and LNTH.
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Drawdown Indicators
| VRTX | LNTH | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.77% | -78.62% | -13.15% |
Max Drawdown (1Y)Largest decline over 1 year | -23.56% | -40.22% | +16.66% |
Max Drawdown (3Y)Largest decline over 3 years | -29.07% | -59.46% | +30.39% |
Max Drawdown (5Y)Largest decline over 5 years | -29.07% | -59.46% | +30.39% |
Max Drawdown (10Y)Largest decline over 10 years | -41.60% | -68.52% | +26.92% |
Current DrawdownCurrent decline from peak | -17.11% | -18.90% | +1.79% |
Average DrawdownAverage peak-to-trough decline | -37.70% | -28.23% | -9.47% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 11.14% | 22.79% | -11.65% |
Volatility
VRTX vs. LNTH - Volatility Comparison
The current volatility for Vertex Pharmaceuticals Incorporated (VRTX) is 7.03%, while Lantheus Holdings, Inc. (LNTH) has a volatility of 13.28%. This indicates that VRTX experiences smaller price fluctuations and is considered to be less risky than LNTH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| VRTX | LNTH | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 7.03% | 13.28% | -6.25% |
Volatility (6M)Calculated over the trailing 6-month period | 21.69% | 25.02% | -3.33% |
Volatility (1Y)Calculated over the trailing 1-year period | 33.88% | 47.26% | -13.38% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 28.90% | 56.89% | -27.99% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 32.82% | 61.96% | -29.14% |
Dividends
VRTX vs. LNTH - Dividend Comparison
Neither VRTX nor LNTH has paid dividends to shareholders.
Financials
VRTX vs. LNTH - Financials Comparison
This section allows you to compare key financial metrics between Vertex Pharmaceuticals Incorporated and Lantheus Holdings, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
VRTX vs. LNTH - Profitability Comparison
VRTX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.59B and revenue of 2.99B. Therefore, the gross margin over that period was 86.9%.
LNTH - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Lantheus Holdings, Inc. reported a gross profit of 230.92M and revenue of 377.33M. Therefore, the gross margin over that period was 61.2%.
VRTX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.14B and revenue of 2.99B, resulting in an operating margin of 38.1%.
LNTH - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Lantheus Holdings, Inc. reported an operating income of 81.33M and revenue of 377.33M, resulting in an operating margin of 21.6%.
VRTX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.03B and revenue of 2.99B, resulting in a net margin of 34.5%.
LNTH - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Lantheus Holdings, Inc. reported a net income of 118.42M and revenue of 377.33M, resulting in a net margin of 31.4%.
Frequently Asked Questions
VRTX and LNTH have a correlation of 0.20, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
LNTH has higher volatility (13.28%) compared to VRTX (7.03%). In terms of maximum drawdown, VRTX dropped -91.77% vs LNTH's -78.62%.
LNTH currently has the higher Sharpe Ratio (0.62 vs -0.12), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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