VRTX vs. LLY
Compare and contrast key facts about Vertex Pharmaceuticals Incorporated (VRTX) and Eli Lilly and Company (LLY).
Performance
VRTX vs. LLY - Performance Comparison
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VRTX vs. LLY - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
VRTX Vertex Pharmaceuticals Incorporated | -1.50% | 12.58% | -1.03% | 40.90% | 31.50% | -7.08% | 7.94% | 32.13% | 10.58% | 103.42% |
LLY Eli Lilly and Company | -14.27% | 40.25% | 33.30% | 60.91% | 34.26% | 66.08% | 31.04% | 16.14% | 40.45% | 17.83% |
Fundamentals
VRTX:
$114.36B
LLY:
$825.96B
VRTX:
$15.35
LLY:
$22.96
VRTX:
29.09
LLY:
40.06
VRTX:
2.42
LLY:
0.81
VRTX:
9.58
LLY:
12.68
VRTX:
6.13
LLY:
31.13
VRTX:
$12.00B
LLY:
$65.18B
VRTX:
$10.35B
LLY:
$54.62B
VRTX:
$4.74B
LLY:
$27.94B
Returns By Period
In the year-to-date period, VRTX achieves a -1.50% return, which is significantly higher than LLY's -14.27% return. Over the past 10 years, VRTX has underperformed LLY with an annualized return of 18.89%, while LLY has yielded a comparatively higher 30.92% annualized return.
VRTX
- 1D
- 0.76%
- 1M
- -10.12%
- YTD
- -1.50%
- 6M
- 14.02%
- 1Y
- -7.90%
- 3Y*
- 12.33%
- 5Y*
- 15.95%
- 10Y*
- 18.89%
LLY
- 1D
- 3.74%
- 1M
- -12.57%
- YTD
- -14.27%
- 6M
- 20.93%
- 1Y
- 12.19%
- 3Y*
- 39.90%
- 5Y*
- 39.16%
- 10Y*
- 30.92%
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Return for Risk
VRTX vs. LLY — Risk / Return Rank
VRTX
LLY
VRTX vs. LLY - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and Eli Lilly and Company (LLY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| VRTX | LLY | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | -0.22 | 0.29 | -0.51 |
Sortino ratioReturn per unit of downside risk | -0.05 | 0.69 | -0.74 |
Omega ratioGain probability vs. loss probability | 0.99 | 1.10 | -0.10 |
Calmar ratioReturn relative to maximum drawdown | -0.33 | 0.42 | -0.75 |
Martin ratioReturn relative to average drawdown | -0.65 | 1.02 | -1.68 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| VRTX | LLY | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.22 | 0.29 | -0.51 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.56 | 1.23 | -0.67 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.57 | 1.04 | -0.47 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.26 | 0.56 | -0.31 |
Correlation
The correlation between VRTX and LLY is 0.27, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
VRTX vs. LLY - Dividend Comparison
VRTX has not paid dividends to shareholders, while LLY's dividend yield for the trailing twelve months is around 0.68%.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
VRTX Vertex Pharmaceuticals Incorporated | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
LLY Eli Lilly and Company | 0.68% | 0.56% | 0.67% | 0.78% | 1.07% | 1.23% | 1.75% | 1.96% | 1.94% | 2.46% | 2.77% | 2.37% |
Drawdowns
VRTX vs. LLY - Drawdown Comparison
The maximum VRTX drawdown since its inception was -91.77%, which is greater than LLY's maximum drawdown of -68.24%. Use the drawdown chart below to compare losses from any high point for VRTX and LLY.
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Drawdown Indicators
| VRTX | LLY | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.77% | -68.24% | -23.53% |
Max Drawdown (1Y)Largest decline over 1 year | -28.06% | -30.26% | +2.20% |
Max Drawdown (5Y)Largest decline over 5 years | -29.07% | -34.48% | +5.41% |
Max Drawdown (10Y)Largest decline over 10 years | -41.60% | -34.48% | -7.12% |
Current DrawdownCurrent decline from peak | -13.59% | -17.00% | +3.41% |
Average DrawdownAverage peak-to-trough decline | -37.81% | -19.25% | -18.56% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 14.33% | 12.39% | +1.94% |
Volatility
VRTX vs. LLY - Volatility Comparison
Vertex Pharmaceuticals Incorporated (VRTX) has a higher volatility of 11.93% compared to Eli Lilly and Company (LLY) at 9.04%. This indicates that VRTX's price experiences larger fluctuations and is considered to be riskier than LLY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| VRTX | LLY | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 11.93% | 9.04% | +2.89% |
Volatility (6M)Calculated over the trailing 6-month period | 21.67% | 26.21% | -4.54% |
Volatility (1Y)Calculated over the trailing 1-year period | 35.83% | 42.44% | -6.61% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 28.77% | 32.14% | -3.37% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 33.24% | 29.80% | +3.44% |
Financials
VRTX vs. LLY - Financials Comparison
This section allows you to compare key financial metrics between Vertex Pharmaceuticals Incorporated and Eli Lilly and Company. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
VRTX vs. LLY - Profitability Comparison
VRTX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.72B and revenue of 3.19B. Therefore, the gross margin over that period was 85.4%.
LLY - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a gross profit of 16.41B and revenue of 19.29B. Therefore, the gross margin over that period was 85.1%.
VRTX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.26B and revenue of 3.19B, resulting in an operating margin of 39.6%.
LLY - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported an operating income of 8.78B and revenue of 19.29B, resulting in an operating margin of 45.5%.
VRTX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.19B and revenue of 3.19B, resulting in a net margin of 37.3%.
LLY - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a net income of 6.64B and revenue of 19.29B, resulting in a net margin of 34.4%.