VRTX vs. BX

Last updated Jun 3, 2026

VRTX (Vertex Pharmaceuticals Incorporated) and BX (The Blackstone Group Inc.) are both stocks. VRTX operates in Biotechnology (Healthcare), while BX operates in Asset Management (Financial Services). Over the past 10 years, VRTX returned 16.29%/yr vs 21.28%/yr for BX. At a 0.27 correlation, their price movements are largely independent.

Performance

VRTX vs. BX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vertex Pharmaceuticals Incorporated (VRTX) and The Blackstone Group Inc. (BX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VRTX achieves a -6.24% return, which is significantly higher than BX's -23.89% return. Over the past 10 years, VRTX has underperformed BX with an annualized return of 16.29%, while BX has yielded a comparatively higher 21.28% annualized return.

VRTX

• 1D: -3.04%
• 1M: 0.28%
• YTD: -6.24%
• 6M: -1.86%
• 1Y: -4.57%
• 3Y*: 8.39%
• 5Y*: 15.02%
• 10Y*: 16.29%

BX

• 1D: -1.74%
• 1M: -8.21%
• YTD: -23.89%
• 6M: -20.05%
• 1Y: -14.21%
• 3Y*: 12.31%
• 5Y*: 8.10%
• 10Y*: 21.28%

*Multi-year figures are annualized to reflect compound growth (CAGR)

VRTX vs. BX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
VRTX Vertex Pharmaceuticals Incorporated	-6.24%	12.58%	-1.03%	40.90%	31.50%	-7.08%	7.94%	32.13%	10.58%	103.42%
BX The Blackstone Group Inc.	-23.89%	-7.84%	35.07%	82.75%	-40.01%	107.11%	19.78%	96.33%	0.10%	27.34%

Correlation

The correlation between VRTX and BX is 0.16, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.16
Correlation (3Y) Calculated over the trailing 3-year period	0.20
Correlation (5Y) Calculated over the trailing 5-year period	0.22
Correlation (10Y) Calculated over the trailing 10-year period	0.25
Correlation (All Time) Calculated using the full available price history since Jun 25, 2007	0.27

The correlation between VRTX and BX shifts across timeframes, from 0.16 (1 year) to 0.27 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap VRTX : $108.95B BX : $90.05B
EPS VRTX : $16.87 BX : $3.90
PE Ratio VRTX : 25.20 BX : 29.44
PEG Ratio VRTX : 2.10 BX : 10.82
PS Ratio VRTX : 8.92 BX : 6.00
PB Ratio VRTX : 4.11 BX : 10.76
Total Revenue (TTM) VRTX : $12.26B BX : $14.99B
Gross Profit (TTM) VRTX : $10.57B BX : $13.12B
EBITDA (TTM) VRTX : $5.19B BX : $7.37B

Return for Risk

VRTX vs. BX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VRTX

VRTX Risk / Return Rank: 33
VRTX Sharpe Ratio Rank: 35
VRTX Sortino Ratio Rank: 31
VRTX Omega Ratio Rank: 31
VRTX Calmar Ratio Rank: 35
VRTX Martin Ratio Rank: 33

BX

BX Risk / Return Rank: 25
BX Sharpe Ratio Rank: 22
BX Sortino Ratio Rank: 21
BX Omega Ratio Rank: 22
BX Calmar Ratio Rank: 30
BX Martin Ratio Rank: 29

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

VRTX vs. BX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and The Blackstone Group Inc. (BX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	VRTX	BX	Difference
Sharpe ratio Return per unit of total volatility	-0.14	-0.43	+0.29
Sortino ratio Return per unit of downside risk	0.05	-0.40	+0.45
Omega ratio Gain probability vs. loss probability	1.01	0.95	+0.06
Calmar ratio Return relative to maximum drawdown	-0.16	-0.32	+0.15
Martin ratio Return relative to average drawdown	-0.35	-0.61	+0.26
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

VRTX vs. BX - Sharpe Ratio Comparison

The current VRTX Sharpe Ratio is -0.14, which is higher than the BX Sharpe Ratio of -0.43. The chart below compares the historical Sharpe Ratios of VRTX and BX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	VRTX	BX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.14	-0.43	+0.29
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.52	0.21	+0.31
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.50	0.60	-0.10
Sharpe Ratio (All Time) Calculated using the full available price history	0.25	0.28	-0.03

Drawdowns

VRTX vs. BX - Drawdown Comparison

The maximum VRTX drawdown since its inception was -91.77%, roughly equal to the maximum BX drawdown of -87.62%. Use the drawdown chart below to compare losses from any high point for VRTX and BX.

Drawdown Indicators

	VRTX	BX	Difference
Max Drawdown Largest peak-to-trough decline	-91.77%	-87.62%	-4.15%
Max Drawdown (1Y) Largest decline over 1 year	-23.56%	-44.76%	+21.20%
Max Drawdown (3Y) Largest decline over 3 years	-29.07%	-46.50%	+17.43%
Max Drawdown (5Y) Largest decline over 5 years	-29.07%	-49.29%	+20.22%
Max Drawdown (10Y) Largest decline over 10 years	-41.60%	-49.29%	+7.69%
Current Drawdown Current decline from peak	-17.74%	-39.24%	+21.50%
Average Drawdown Average peak-to-trough decline	-37.70%	-25.69%	-12.01%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.11%	23.35%	-12.24%

Volatility

VRTX vs. BX - Volatility Comparison

The current volatility for Vertex Pharmaceuticals Incorporated (VRTX) is 7.13%, while The Blackstone Group Inc. (BX) has a volatility of 7.83%. This indicates that VRTX experiences smaller price fluctuations and is considered to be less risky than BX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VRTX	BX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.13%	7.83%	-0.70%
Volatility (6M) Calculated over the trailing 6-month period	21.76%	26.81%	-5.05%
Volatility (1Y) Calculated over the trailing 1-year period	33.88%	33.39%	+0.49%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	28.90%	39.14%	-10.24%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.83%	35.66%	-2.83%

Dividends

VRTX vs. BX - Dividend Comparison

VRTX has not paid dividends to shareholders, while BX's dividend yield for the trailing twelve months is around 4.33%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
BX The Blackstone Group Inc.	4.33%	3.04%	2.00%	2.54%	6.66%	2.76%	2.95%	3.43%	8.12%	7.25%	6.14%	11.76%
VRTX Vertex Pharmaceuticals Incorporated	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

VRTX vs. BX - Profitability Comparison

The chart below illustrates the profitability comparison between Vertex Pharmaceuticals Incorporated and The Blackstone Group Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

VRTX - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.59B and revenue of 2.99B. Therefore, the gross margin over that period was 86.9%.

BX - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, The Blackstone Group Inc. reported a gross profit of 4.04B and revenue of 4.10B. Therefore, the gross margin over that period was 98.5%.

VRTX - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.14B and revenue of 2.99B, resulting in an operating margin of 38.1%.

BX - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, The Blackstone Group Inc. reported an operating income of 1.59B and revenue of 4.10B, resulting in an operating margin of 38.8%.

VRTX - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.03B and revenue of 2.99B, resulting in a net margin of 34.5%.

BX - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, The Blackstone Group Inc. reported a net income of 649.73M and revenue of 4.10B, resulting in a net margin of 15.8%.

Frequently Asked Questions

Can I hold both VRTX and BX in my portfolio?

VRTX and BX have a correlation of 0.16, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VRTX or BX?

BX has higher volatility (7.83%) compared to VRTX (7.13%). In terms of maximum drawdown, VRTX dropped -91.77% vs BX's -87.62%.

Which has better risk-adjusted returns?

VRTX currently has the higher Sharpe Ratio (-0.14 vs -0.43), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.