VRTX vs. VLO
Compare and contrast key facts about Vertex Pharmaceuticals Incorporated (VRTX) and Valero Energy Corporation (VLO).
Performance
VRTX vs. VLO - Performance Comparison
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VRTX vs. VLO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
VRTX Vertex Pharmaceuticals Incorporated | -1.50% | 12.58% | -1.03% | 40.90% | 31.50% | -7.08% | 7.94% | 32.13% | 10.58% | 103.42% |
VLO Valero Energy Corporation | 52.71% | 36.97% | -2.96% | 5.86% | 74.95% | 40.25% | -35.69% | 30.27% | -15.73% | 38.66% |
Fundamentals
VRTX:
$114.36B
VLO:
$74.87B
VRTX:
$15.35
VLO:
$7.74
VRTX:
29.09
VLO:
31.93
VRTX:
2.42
VLO:
0.12
VRTX:
9.58
VLO:
0.61
VRTX:
6.13
VLO:
2.81
VRTX:
$12.00B
VLO:
$124.05B
VRTX:
$10.35B
VLO:
$6.75B
VRTX:
$4.74B
VLO:
$6.49B
Returns By Period
In the year-to-date period, VRTX achieves a -1.50% return, which is significantly lower than VLO's 52.71% return. Both investments have delivered pretty close results over the past 10 years, with VRTX having a 18.89% annualized return and VLO not far ahead at 19.18%.
VRTX
- 1D
- 0.76%
- 1M
- -10.12%
- YTD
- -1.50%
- 6M
- 14.02%
- 1Y
- -7.90%
- 3Y*
- 12.33%
- 5Y*
- 15.95%
- 10Y*
- 18.89%
VLO
- 1D
- -1.27%
- 1M
- 20.74%
- YTD
- 52.71%
- 6M
- 46.93%
- 1Y
- 92.58%
- 3Y*
- 24.69%
- 5Y*
- 31.29%
- 10Y*
- 19.18%
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Return for Risk
VRTX vs. VLO — Risk / Return Rank
VRTX
VLO
VRTX vs. VLO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and Valero Energy Corporation (VLO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| VRTX | VLO | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | -0.22 | 2.40 | -2.62 |
Sortino ratioReturn per unit of downside risk | -0.05 | 2.86 | -2.91 |
Omega ratioGain probability vs. loss probability | 0.99 | 1.41 | -0.42 |
Calmar ratioReturn relative to maximum drawdown | -0.33 | 4.30 | -4.64 |
Martin ratioReturn relative to average drawdown | -0.65 | 12.77 | -13.42 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| VRTX | VLO | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.22 | 2.40 | -2.62 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.56 | 0.86 | -0.30 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.57 | 0.48 | +0.09 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.26 | 0.28 | -0.02 |
Correlation
The correlation between VRTX and VLO is 0.19, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
VRTX vs. VLO - Dividend Comparison
VRTX has not paid dividends to shareholders, while VLO's dividend yield for the trailing twelve months is around 1.86%.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
VRTX Vertex Pharmaceuticals Incorporated | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
VLO Valero Energy Corporation | 1.86% | 2.78% | 3.49% | 3.14% | 3.09% | 5.22% | 6.93% | 3.84% | 4.27% | 2.34% | 3.51% | 2.40% |
Drawdowns
VRTX vs. VLO - Drawdown Comparison
The maximum VRTX drawdown since its inception was -91.77%, roughly equal to the maximum VLO drawdown of -87.50%. Use the drawdown chart below to compare losses from any high point for VRTX and VLO.
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Drawdown Indicators
| VRTX | VLO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.77% | -87.50% | -4.27% |
Max Drawdown (1Y)Largest decline over 1 year | -28.06% | -21.72% | -6.34% |
Max Drawdown (5Y)Largest decline over 5 years | -29.07% | -41.22% | +12.15% |
Max Drawdown (10Y)Largest decline over 10 years | -41.60% | -71.88% | +30.28% |
Current DrawdownCurrent decline from peak | -13.59% | -2.85% | -10.74% |
Average DrawdownAverage peak-to-trough decline | -37.81% | -34.39% | -3.42% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 14.33% | 7.32% | +7.01% |
Volatility
VRTX vs. VLO - Volatility Comparison
Vertex Pharmaceuticals Incorporated (VRTX) and Valero Energy Corporation (VLO) have volatilities of 11.93% and 11.92%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| VRTX | VLO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 11.93% | 11.92% | +0.01% |
Volatility (6M)Calculated over the trailing 6-month period | 21.67% | 25.37% | -3.70% |
Volatility (1Y)Calculated over the trailing 1-year period | 35.83% | 38.84% | -3.01% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 28.77% | 36.71% | -7.94% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 33.24% | 40.18% | -6.94% |
Financials
VRTX vs. VLO - Financials Comparison
This section allows you to compare key financial metrics between Vertex Pharmaceuticals Incorporated and Valero Energy Corporation. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
VRTX vs. VLO - Profitability Comparison
VRTX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.72B and revenue of 3.19B. Therefore, the gross margin over that period was 85.4%.
VLO - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Valero Energy Corporation reported a gross profit of 3.26B and revenue of 31.73B. Therefore, the gross margin over that period was 10.3%.
VRTX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.26B and revenue of 3.19B, resulting in an operating margin of 39.6%.
VLO - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Valero Energy Corporation reported an operating income of 1.58B and revenue of 31.73B, resulting in an operating margin of 5.0%.
VRTX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.19B and revenue of 3.19B, resulting in a net margin of 37.3%.
VLO - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Valero Energy Corporation reported a net income of 1.17B and revenue of 31.73B, resulting in a net margin of 3.7%.