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VRTX vs. APLS
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Correlation

The correlation between VRTX and APLS is 0.44, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.


Performance

VRTX vs. APLS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vertex Pharmaceuticals Incorporated (VRTX) and Apellis Pharmaceuticals, Inc. (APLS). The values are adjusted to include any dividend payments, if applicable.

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Key characteristics

Sharpe Ratio

VRTX:

-0.06

APLS:

-1.11

Sortino Ratio

VRTX:

0.17

APLS:

-1.84

Omega Ratio

VRTX:

1.02

APLS:

0.78

Calmar Ratio

VRTX:

-0.02

APLS:

-0.73

Martin Ratio

VRTX:

-0.04

APLS:

-1.85

Ulcer Index

VRTX:

9.00%

APLS:

32.49%

Daily Std Dev

VRTX:

28.47%

APLS:

53.70%

Max Drawdown

VRTX:

-91.77%

APLS:

-82.10%

Current Drawdown

VRTX:

-18.50%

APLS:

-82.10%

Fundamentals

Market Cap

VRTX:

$110.94B

APLS:

$2.17B

EPS

VRTX:

-$3.82

APLS:

-$1.80

PS Ratio

VRTX:

9.99

APLS:

2.80

PB Ratio

VRTX:

6.72

APLS:

13.41

Total Revenue (TTM)

VRTX:

$11.09B

APLS:

$775.84M

Gross Profit (TTM)

VRTX:

$9.54B

APLS:

$643.52M

EBITDA (TTM)

VRTX:

-$228.00M

APLS:

-$176.07M

Returns By Period

In the year-to-date period, VRTX achieves a 4.58% return, which is significantly higher than APLS's -47.67% return.


VRTX

YTD

4.58%

1M

-15.06%

6M

-14.85%

1Y

-1.73%

5Y*

7.88%

10Y*

12.84%

APLS

YTD

-47.67%

1M

-13.61%

6M

-40.88%

1Y

-59.47%

5Y*

-11.68%

10Y*

N/A

*Annualized

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Risk-Adjusted Performance

VRTX vs. APLS — Risk-Adjusted Performance Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VRTX
The Risk-Adjusted Performance Rank of VRTX is 4545
Overall Rank
The Sharpe Ratio Rank of VRTX is 4848
Sharpe Ratio Rank
The Sortino Ratio Rank of VRTX is 4040
Sortino Ratio Rank
The Omega Ratio Rank of VRTX is 4141
Omega Ratio Rank
The Calmar Ratio Rank of VRTX is 4949
Calmar Ratio Rank
The Martin Ratio Rank of VRTX is 4949
Martin Ratio Rank

APLS
The Risk-Adjusted Performance Rank of APLS is 44
Overall Rank
The Sharpe Ratio Rank of APLS is 22
Sharpe Ratio Rank
The Sortino Ratio Rank of APLS is 33
Sortino Ratio Rank
The Omega Ratio Rank of APLS is 44
Omega Ratio Rank
The Calmar Ratio Rank of APLS is 77
Calmar Ratio Rank
The Martin Ratio Rank of APLS is 11
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

VRTX vs. APLS - Risk-Adjusted Performance Comparison

This table presents a comparison of risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and Apellis Pharmaceuticals, Inc. (APLS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.


The current VRTX Sharpe Ratio is -0.06, which is higher than the APLS Sharpe Ratio of -1.11. The chart below compares the historical Sharpe Ratios of VRTX and APLS, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.


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Dividends

VRTX vs. APLS - Dividend Comparison

Neither VRTX nor APLS has paid dividends to shareholders.


Tickers have no history of dividend payments

Drawdowns

VRTX vs. APLS - Drawdown Comparison

The maximum VRTX drawdown since its inception was -91.77%, which is greater than APLS's maximum drawdown of -82.10%. Use the drawdown chart below to compare losses from any high point for VRTX and APLS. For additional features, visit the drawdowns tool.


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Volatility

VRTX vs. APLS - Volatility Comparison

Vertex Pharmaceuticals Incorporated (VRTX) and Apellis Pharmaceuticals, Inc. (APLS) have volatilities of 13.18% and 13.40%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.


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Financials

VRTX vs. APLS - Financials Comparison

This section allows you to compare key financial metrics between Vertex Pharmaceuticals Incorporated and Apellis Pharmaceuticals, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.


Quarterly
Annual

Total Revenue: Total amount of money received from sales and other business activities


0.00500.00M1.00B1.50B2.00B2.50B3.00B20212022202320242025
2.77B
166.80M
(VRTX) Total Revenue
(APLS) Total Revenue
Values in USD except per share items

VRTX vs. APLS - Profitability Comparison

The chart below illustrates the profitability comparison between Vertex Pharmaceuticals Incorporated and Apellis Pharmaceuticals, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

Gross Margin
Operating Margin
Net Margin
Quarterly
Annual

80.0%85.0%90.0%95.0%100.0%20212022202320242025
86.9%
79.4%
(VRTX) Gross Margin
(APLS) Gross Margin
VRTX - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on May 2025, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.41B and revenue of 2.77B. Therefore, the gross margin over that period was 86.9%.

APLS - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on May 2025, Apellis Pharmaceuticals, Inc. reported a gross profit of 132.44M and revenue of 166.80M. Therefore, the gross margin over that period was 79.4%.

VRTX - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on May 2025, Vertex Pharmaceuticals Incorporated reported an operating income of 630.10M and revenue of 2.77B, resulting in an operating margin of 22.8%.

APLS - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on May 2025, Apellis Pharmaceuticals, Inc. reported an operating income of -83.33M and revenue of 166.80M, resulting in an operating margin of -50.0%.

VRTX - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on May 2025, Vertex Pharmaceuticals Incorporated reported a net income of 646.30M and revenue of 2.77B, resulting in a net margin of 23.3%.

APLS - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on May 2025, Apellis Pharmaceuticals, Inc. reported a net income of -92.23M and revenue of 166.80M, resulting in a net margin of -55.3%.