Horizon Kinetics SPAC Active ETF (SPAQ) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with SPAQ. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to SPAQ
SPAQ charges 0.85% annually. There are 57 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | SPAQ vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | SPAQ vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | SPAQ vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | SPAQ vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | SPAQ vs GSKH |
Best Risk-Adjusted Alternatives to SPAQ
SPAQ has a PortfoliosLab risk / return rank of 22. There are 48 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | SPAQ vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | SPAQ vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | SPAQ vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 93 | 1.34B | May 2006 | SPAQ vs IHE | |
| iShares Neuroscience and Healthcare ETF | 92 | 5.85M | Aug 2022 | SPAQ vs IBRN |
Top Performing SPAQ Alternatives (YTD)
SPAQ is at 3.23% YTD. There are 43 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 41.70%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 41.70% | 1.31B | Oct 2014 | SPAQ vs ARKG | |
| AdvisorShares Psychedelics ETF | 38.20% | 44.37M | Sep 2021 | SPAQ vs PSIL | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.75% | 57.56M | Dec 2014 | SPAQ vs BBC | |
| Roundhill UNH WeeklyPay ETF | 32.80% | 6.01M | Dec 2025 | SPAQ vs UNHW | |
| SPDR S&P Biotech ETF | 27.62% | 11.10B | Feb 2006 | SPAQ vs XBI |
Lowest Volatility Alternatives to SPAQ
SPAQ has 8.63% 1-year volatility. There are 2 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | SPAQ vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | SPAQ vs GERM | |
| State Street Health Care Select Sector SPDR Premiu... | 10.96% | 16.78M | Jul 2025 | SPAQ vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.68% | 982.35K | Apr 2026 | SPAQ vs MHIP | |
| Global X Aging Population ETF | 14.03% | 85.65M | May 2016 | SPAQ vs AGNG |
Lowest Drawdown Alternatives to SPAQ
SPAQ has a 1-year max drawdown of -4.32%. There is 1 ETF in the Health & Biotech Equities category with a shallower 1-year drawdown, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | SPAQ vs GERM | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | SPAQ vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | SPAQ vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | SPAQ vs IHE | |
| iShares Neuroscience and Healthcare ETF | -8.80% | 5.85M | Aug 2022 | SPAQ vs IBRN |
Other ETFs from Horizon
The 10 most viewed Horizon ETFs shown here include BCDF, MEDX, NVIR and span 12 categories. AUM among these funds goes as high as $411M.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Horizon Kinetics Blockchain Development ETF | Cryptocurrency | 12 | 3.60% | 22.57M | Aug 2022 | SPAQ vs BCDF | |
| Horizon Kinetics Medical ETF | Health & Biotech Equities | 54 | 5.07% | 18.92M | Sep 1999 | SPAQ vs MEDX | |
| Horizon Kinetics Energy Remediation ETF | Energy Equities | 60 | 19.05% | 5.75M | Feb 2023 | SPAQ vs NVIR | |
| Horizon International Managed Risk ETF | Tactical Allocation | — | 18.32% | 410.55M | Dec 2025 | SPAQ vs SFTX | |
| Horizon Landmark ETF | Ultrashort Bond | 98 | 1.88% | 210.01M | Jan 2025 | SPAQ vs BENJ | |
| Horizon Kinetics Japan Owner Operator ETF | Japan Equities, Asia Pacific Equities | 6 | -3.49% | — | May 2025 | SPAQ vs JAPN | |
| Horizon Expedition Plus ETF | Derivative Income | 56 | 13.03% | 133.99M | Jan 2025 | SPAQ vs HBTA | |
| Horizon NASDAQ-100 Defined Risk ETF | Equity Hedged, Nasdaq-100 | 52 | 12.03% | 79.22M | Jul 2025 | SPAQ vs QGRD | |
| Horizon Digital Frontier ETF | Technology Equities | 37 | 13.83% | 98.39M | Jul 2025 | SPAQ vs YNOT | |
| Horizon Small/Mid Cap Core Equity ETF | Mid Cap Blend Equities | — | 19.74% | 57.59M | Dec 2025 | SPAQ vs SMOX |
Often Compared With SPAQ
Investors most often compare SPAQ with MEDI, SPY, STIP. These 20 comparison targets span 3 categories, based on PortfoliosLab usage data.
Compare SPAQ with Any Fund or Stock
Compare SPAQ with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair SPAQ with funds that move differently
Horizon Kinetics SPAC Active ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to SPAQ.
Explore SPAQ Diversifiers