Direxion Daily Pharmaceutical & Medical Bull 3X Shares (PILL) belongs to the Leveraged Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PILL. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PILL
PILL charges 0.98% annually. There are 208 ETFs in the Leveraged Equities category with lower expense ratios, going as low as 0.35%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| WisdomTree Efficient U.S. Plus International Equit... | 0.35% | 43.18M | Mar 2026 | PILL vs NTSD | |
| ETRACS IFED Invest with the Fed TR Index ETN | 0.45% | 48.07M | Sep 2021 | PILL vs IFED | |
| Corgi BRKB 2x Daily ETF | 0.45% | — | Jul 2026 | PILL vs BRKL | |
| Direxion Daily S&P 500 Bull 2X ETF | 0.60% | 260.25M | May 2014 | PILL vs SPUU | |
| Leverage Shares 2X Long OKTA Daily ETF | 0.75% | 2.54M | Nov 2025 | PILL vs OKTG |
Best Risk-Adjusted Alternatives to PILL
PILL has a PortfoliosLab risk / return rank of 95. There are 5 ETFs in the Leveraged Equities category with higher risk-adjusted ranks, going as high as 98.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Direxion Daily MU Bull 2X Shares | 98 | 3.86B | Oct 2024 | PILL vs MUU | |
| GraniteShares 2x Long MU Daily ETF | 98 | 531.06M | Nov 2024 | PILL vs MULL | |
| Innovator U.S. Equity Accelerated Plus ETF | 98 | 22.69M | Apr 2021 | PILL vs XTAP | |
| GraniteShares 2x Long INTC Daily ETF | 97 | 282.58M | Feb 2025 | PILL vs INTW | |
| Innovator Growth Accelerated Plus ETF - April | 97 | 20.37M | Apr 2021 | PILL vs QTAP |
Top Performing PILL Alternatives (YTD)
PILL is at 53.57% YTD. There are 40 ETFs in the Leveraged Equities category with higher YTD returns, going as high as 615.57%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| GraniteShares 2x Long DELL Daily ETF | 615.57% | 101.24M | Feb 2025 | PILL vs DLLL | |
| Direxion Daily MU Bull 2X Shares | 372.51% | 3.86B | Oct 2024 | PILL vs MUU | |
| GraniteShares 2x Long MU Daily ETF | 359.36% | 531.06M | Nov 2024 | PILL vs MULL | |
| Direxion Daily INTC Bull 2X Shares | 259.95% | 63.06M | Nov 2025 | PILL vs LINT | |
| GraniteShares 2x Long INTC Daily ETF | 259.86% | 282.58M | Feb 2025 | PILL vs INTW |
Lowest Volatility Alternatives to PILL
PILL has 65.62% 1-year volatility. There are 170 ETFs in the Leveraged Equities category with lower 1-year volatility, going as low as 4.93%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Innovator U.S. Equity Accelerated Plus ETF | 4.93% | 22.69M | Apr 2021 | PILL vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | 6.61% | 20.37M | Apr 2021 | PILL vs QTAP | |
| Innovator U.S. Equity Accelerated Plus ETF - July | 7.79% | 13.42M | Jul 2021 | PILL vs XTJL | |
| Innovator US Equity Accelerated ETF | 10.98% | 69.34M | Apr 2021 | PILL vs XDSQ | |
| Innovator Growth Accelerated Plus ETF - July | 11.72% | 19.11M | Jul 2021 | PILL vs QTJL |
Lowest Drawdown Alternatives to PILL
PILL has a 1-year max drawdown of -33.21%. There are 76 ETFs in the Leveraged Equities category with shallower 1-year drawdowns, going as shallow as -1.72%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Innovator U.S. Equity Accelerated Plus ETF | -1.72% | 22.69M | Apr 2021 | PILL vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | -2.81% | 20.37M | Apr 2021 | PILL vs QTAP | |
| Innovator U.S. Equity Accelerated Plus ETF - July | -5.12% | 13.42M | Jul 2021 | PILL vs XTJL | |
| Innovator Growth Accelerated Plus ETF - July | -8.48% | 19.11M | Jul 2021 | PILL vs QTJL | |
| Innovator US Equity Accelerated ETF | -9.60% | 69.34M | Apr 2021 | PILL vs XDSQ |
Other ETFs from Direxion
The 10 most viewed Direxion ETFs shown here include SOXL, SPXL, TECL and span 9 categories. AUM among these funds goes as high as $20B.
Often Compared With PILL
Investors most often compare PILL with CURE, BNKU, KURE. These 20 comparison targets span 12 categories, based on PortfoliosLab usage data.
Compare PILL with Any Fund or Stock
Compare PILL with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PILL with funds that move differently
Direxion Daily Pharmaceutical & Medical Bull 3X Shares alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PILL.
Explore PILL Diversifiers