First Trust Amex Biotechnology Index (FBT) Alternatives
First Trust Amex Biotechnology Index (FBT) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with FBT. Use the tables to find lower-cost options, better risk-adjusted returns, or funds that fit a different role in your portfolio.
Cheapest Alternatives to FBT
FBT charges 0.57% annually. Among ETFs in the Health & Biotech Equities category, these options have the lowest expense ratios among FBT alternatives.
| Symbol | Name | Expense Ratio | Inception | |
|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | Oct 21, 2013 | FBT vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | Dec 16, 1998 | FBT vs XLV | |
| Vanguard Health Care ETF | 0.10% | Jan 26, 2004 | FBT vs VHT | |
| Invesco S&P SmallCap Health Care ETF | 0.29% | Apr 7, 2010 | FBT vs PSCH | |
| SPDR S&P Pharmaceuticals ETF | 0.35% | Jun 19, 2006 | FBT vs XPH |
Best Risk-Adjusted Alternatives to FBT
Among ETFs in the Health & Biotech Equities category, these options rank highest on PortfoliosLab's risk-adjusted score, which accounts for volatility, drawdown, and return consistency over a 1-year period.
| Symbol | Name | Risk / Return Rank | Inception | |
|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 97 | Dec 16, 2014 | FBT vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | Dec 31, 2014 | FBT vs SBIO | |
| SPDR S&P Biotech ETF | 92 | Feb 6, 2006 | FBT vs XBI | |
| Tema Oncology ETF | 90 | Aug 14, 2023 | FBT vs CANC | |
| F/m Emerald Life Sciences Innovation ETF | 86 | Oct 30, 2024 | FBT vs LFSC |
Top Performing FBT Alternatives (YTD)
FBT alternatives from the Health & Biotech Equities category, sorted by year-to-date return.
| Symbol | Name | YTD Return | Inception | |
|---|---|---|---|---|
| iShares Genomics Immunology and Healthcare ETF Gen... | 10.92% | Jun 11, 2019 | FBT vs IDNA | |
| Virtus LifeSci Biotech Clinical Trials ETF | 7.95% | Dec 16, 2014 | FBT vs BBC | |
| Tema Oncology ETF | 5.69% | Aug 14, 2023 | FBT vs CANC | |
| SPDR S&P Biotech ETF | 4.76% | Feb 6, 2006 | FBT vs XBI | |
| First Trust Nasdaq Pharmaceuticals ETF | 4.48% | Sep 20, 2016 | FBT vs FTXH |
Lowest Volatility Alternatives to FBT
FBT alternatives from the Health & Biotech Equities category, sorted by annualized volatility over the past year.
| Symbol | Name | Volatility 1Y | Inception | |
|---|---|---|---|---|
| Principal Healthcare Innovators Index ETF | 0.00% | Aug 19, 2016 | FBT vs BTEC | |
| Loncar Cancer Immunotherapy ETF | 0.00% | Oct 13, 2015 | FBT vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | Jun 17, 2020 | FBT vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.60% | Jun 29, 2007 | FBT vs SPAQ | |
| Global X Aging Population ETF | 15.94% | May 9, 2016 | FBT vs AGNG |
Lowest Drawdown Alternatives to FBT
FBT alternatives from the Health & Biotech Equities category, sorted by maximum drawdown over the past year.
| Symbol | Name | Max Drawdown 1Y | Inception | |
|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | Jun 17, 2020 | FBT vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.30% | Jun 29, 2007 | FBT vs SPAQ | |
| Jpmorgan Healthcare Leaders ETF | -9.68% | Nov 1, 2023 | FBT vs JDOC | |
| VanEck Vectors Pharmaceutical ETF | -10.02% | Dec 20, 2011 | FBT vs PPH | |
| Global X Aging Population ETF | -10.16% | May 9, 2016 | FBT vs AGNG |
Other ETFs from First Trust
Most popular First Trust ETFs on PortfoliosLab, across asset classes.
Often Compared With FBT
What investors most often compare with FBT, based on PortfoliosLab usage data.
Compare FBT with Any Fund or Stock
Compare FBT with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.