ZYME vs. VST

Last updated Jun 24, 2026

ZYME (Zymeworks Inc.) and VST (Vistra Corp.) are both stocks. ZYME operates in Biotechnology (Healthcare), while VST operates in Utilities - Independent Power Producers (Utilities). Over the past 5 years, ZYME returned -8.24%/yr vs 57.72%/yr for VST. At a 0.12 correlation, their price movements are largely independent.

Performance

ZYME vs. VST - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Zymeworks Inc. (ZYME) and Vistra Corp. (VST). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ZYME achieves a -9.30% return, which is significantly lower than VST's 0.94% return.

ZYME

• 1D: 2.67%
• 1M: -6.76%
• YTD: -9.30%
• 6M: -10.86%
• 1Y: 91.50%
• 3Y*: 43.33%
• 5Y*: -8.24%
• 10Y*: —

VST

• 1D: -2.91%
• 1M: 4.06%
• YTD: 0.94%
• 6M: 0.72%
• 1Y: -12.49%
• 3Y*: 88.21%
• 5Y*: 57.72%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ZYME vs. VST - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ZYME Zymeworks Inc.	-9.30%	79.85%	40.90%	32.19%	-52.04%	-65.32%	3.96%	209.67%	93.33%	-43.75%
VST Vistra Corp.	0.94%	17.66%	261.52%	70.73%	5.08%	19.57%	-11.87%	2.46%	24.95%	20.37%

Correlation

The correlation between ZYME and VST is 0.06, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.06
Correlation (3Y) Calculated over the trailing 3-year period	0.14
Correlation (5Y) Calculated over the trailing 5-year period	0.14
Correlation (All Time) Calculated using the full available price history since Apr 28, 2017	0.12

Fundamentals

EPS ZYME : -$583.41 VST : $8.60
PS Ratio ZYME : 22.95 VST : 2.41
Total Revenue (TTM) ZYME : $78.86M VST : $17.20B
Gross Profit (TTM) ZYME : $77.16M VST : $1.12B
EBITDA (TTM) ZYME : -$47.18B VST : $4.34B

Return for Risk

ZYME vs. VST — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ZYME

ZYME Risk / Return Rank: 87
ZYME Sharpe Ratio Rank: 86
ZYME Sortino Ratio Rank: 86
ZYME Omega Ratio Rank: 84
ZYME Calmar Ratio Rank: 90
ZYME Martin Ratio Rank: 87

VST

VST Risk / Return Rank: 31
VST Sharpe Ratio Rank: 32
VST Sortino Ratio Rank: 31
VST Omega Ratio Rank: 31
VST Calmar Ratio Rank: 32
VST Martin Ratio Rank: 31

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ZYME vs. VST - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Zymeworks Inc. (ZYME) and Vistra Corp. (VST). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ZYME	VST	Difference
Sharpe ratio: Return per unit of total volatility	1.74	-0.26	+1.99
Sortino ratio: Return per unit of downside risk	2.69	-0.04	+2.73
Omega ratio: Gain probability vs. loss probability	1.33	1.00	+0.33
Calmar ratio: Return relative to maximum drawdown	4.33	-0.33	+4.66
Martin ratio: Return relative to average drawdown	9.21	-0.59	+9.80

ZYME vs. VST - Sharpe Ratio Comparison

The current ZYME Sharpe Ratio is 1.74, which is higher than the VST Sharpe Ratio of -0.26. The chart below compares the historical Sharpe Ratios of ZYME and VST, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ZYME vs. VST - Drawdown Comparison

The maximum ZYME drawdown since its inception was -91.81%, which is greater than VST's maximum drawdown of -53.32%. Use the drawdown chart below to compare losses from any high point for ZYME and VST.

Drawdown Indicators

	ZYME	VST	Difference
Max Drawdown Largest peak-to-trough decline	-91.81%	-53.32%	-38.49%
Max Drawdown (1Y) Largest decline over 1 year	-21.25%	-38.01%	+16.76%
Max Drawdown (3Y) Largest decline over 3 years	-45.75%	-48.80%	+3.05%
Max Drawdown (5Y) Largest decline over 5 years	-87.53%	-48.80%	-38.73%
Current Drawdown Current decline from peak	-57.97%	-25.17%	-32.80%
Average Drawdown Average peak-to-trough decline	-52.54%	-13.75%	-38.79%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.97%	21.12%	-11.15%

Volatility

ZYME vs. VST - Volatility Comparison

The current volatility for Zymeworks Inc. (ZYME) is 10.12%, while Vistra Corp. (VST) has a volatility of 14.36%. This indicates that ZYME experiences smaller price fluctuations and is considered to be less risky than VST based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ZYME	VST	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.12%	14.36%	-4.24%
Volatility (6M) Calculated over the trailing 6-month period	29.45%	36.88%	-7.43%
Volatility (1Y) Calculated over the trailing 1-year period	52.91%	48.93%	+3.98%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	61.85%	48.04%	+13.81%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	61.45%	42.22%	+19.23%

Dividends

ZYME vs. VST - Dividend Comparison

ZYME has not paid dividends to shareholders, while VST's dividend yield for the trailing twelve months is around 0.56%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016
VST Vistra Corp.	0.56%	0.56%	0.63%	2.13%	3.12%	2.64%	2.75%	2.17%	0.00%	0.00%	14.97%
ZYME Zymeworks Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

Frequently Asked Questions

Can I hold both ZYME and VST in my portfolio?

ZYME and VST have a correlation of 0.06, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ZYME or VST?

VST has higher volatility (14.36%) compared to ZYME (10.12%). In terms of maximum drawdown, ZYME dropped -91.81% vs VST's -53.32%.

Which has better risk-adjusted returns?

ZYME currently has the higher Sharpe Ratio (1.74 vs -0.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.