XLO vs. GRID

Last updated Jun 4, 2026

XLO (Xilio Therapeutics, Inc.) is a stock, while GRID (First Trust Nasdaq Clean Edge Smart GRID Infrastructure Index) is Alternative Energy Equities fund tracking the NASDAQ OMX Clean Edge Smart Grid Infrastructure Index. Over the past 3 years, XLO returned -41.99%/yr vs 26.27%/yr for GRID. At a 0.16 correlation, their price movements are largely independent.

Performance

XLO vs. GRID - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Xilio Therapeutics, Inc. (XLO) and First Trust Nasdaq Clean Edge Smart GRID Infrastructure Index (GRID). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XLO achieves a -9.12% return, which is significantly lower than GRID's 28.91% return.

XLO

• 1D: -0.67%
• 1M: -2.22%
• YTD: -9.12%
• 6M: -17.59%
• 1Y: -13.92%
• 3Y*: -41.99%
• 5Y*: —
• 10Y*: —

GRID

• 1D: -0.17%
• 1M: 3.85%
• YTD: 28.91%
• 6M: 29.60%
• 1Y: 51.55%
• 3Y*: 26.27%
• 5Y*: 17.84%
• 10Y*: 19.76%

*Multi-year figures are annualized to reflect compound growth (CAGR)

XLO vs. GRID - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
XLO Xilio Therapeutics, Inc.	-9.12%	-32.96%	73.64%	-79.55%	-83.19%	0.00%
GRID First Trust Nasdaq Clean Edge Smart GRID Infrastructure Index	28.91%	29.65%	15.18%	21.57%	-13.89%	4.79%

Correlation

The correlation between XLO and GRID is 0.18, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.18
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (All Time) Calculated using the full available price history since Oct 25, 2021	0.16

Return for Risk

XLO vs. GRID — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XLO

XLO Risk / Return Rank: 28
XLO Sharpe Ratio Rank: 28
XLO Sortino Ratio Rank: 27
XLO Omega Ratio Rank: 27
XLO Calmar Ratio Rank: 30
XLO Martin Ratio Rank: 29

GRID

GRID Risk / Return Rank: 79
GRID Sharpe Ratio Rank: 81
GRID Sortino Ratio Rank: 76
GRID Omega Ratio Rank: 74
GRID Calmar Ratio Rank: 82
GRID Martin Ratio Rank: 82

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XLO vs. GRID - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Xilio Therapeutics, Inc. (XLO) and First Trust Nasdaq Clean Edge Smart GRID Infrastructure Index (GRID). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	XLO	GRID	Difference
Sharpe ratio: Return per unit of total volatility	-0.30	2.67	-2.97
Sortino ratio: Return per unit of downside risk	-0.14	3.50	-3.64
Omega ratio: Gain probability vs. loss probability	0.98	1.45	-0.47
Calmar ratio: Return relative to maximum drawdown	-0.34	4.42	-4.76
Martin ratio: Return relative to average drawdown	-0.62	16.72	-17.34
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

XLO vs. GRID - Sharpe Ratio Comparison

The current XLO Sharpe Ratio is -0.30, which is lower than the GRID Sharpe Ratio of 2.67. The chart below compares the historical Sharpe Ratios of XLO and GRID, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	XLO	GRID	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.30	2.67	-2.97
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.85	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.87	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.42	0.57	-0.99

Drawdowns

XLO vs. GRID - Drawdown Comparison

The maximum XLO drawdown since its inception was -98.01%, which is greater than GRID's maximum drawdown of -40.56%. Use the drawdown chart below to compare losses from any high point for XLO and GRID.

Drawdown Indicators

	XLO	GRID	Difference
Max Drawdown Largest peak-to-trough decline	-98.01%	-40.56%	-57.45%
Max Drawdown (1Y) Largest decline over 1 year	-40.90%	-11.73%	-29.17%
Max Drawdown (3Y) Largest decline over 3 years	-83.78%	-20.77%	-63.01%
Max Drawdown (5Y) Largest decline over 5 years	—	-29.64%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-40.56%	—
Current Drawdown Current decline from peak	-97.68%	-1.33%	-96.35%
Average Drawdown Average peak-to-trough decline	-88.72%	-8.43%	-80.29%
Ulcer Index Depth and duration of drawdowns from previous peaks	22.36%	3.09%	+19.27%

Volatility

XLO vs. GRID - Volatility Comparison

Xilio Therapeutics, Inc. (XLO) has a higher volatility of 17.86% compared to First Trust Nasdaq Clean Edge Smart GRID Infrastructure Index (GRID) at 7.95%. This indicates that XLO's price experiences larger fluctuations and is considered to be riskier than GRID based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XLO	GRID	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.86%	7.95%	+9.91%
Volatility (6M) Calculated over the trailing 6-month period	34.24%	16.08%	+18.16%
Volatility (1Y) Calculated over the trailing 1-year period	46.61%	19.39%	+27.22%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	121.86%	21.00%	+100.86%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	121.86%	22.81%	+99.05%

Dividends

XLO vs. GRID - Dividend Comparison

XLO has not paid dividends to shareholders, while GRID's dividend yield for the trailing twelve months is around 0.77%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GRID First Trust Nasdaq Clean Edge Smart GRID Infrastructure Index	0.77%	1.01%	1.06%	1.23%	1.26%	0.63%	0.68%	1.26%	1.28%	1.07%	1.07%	1.23%
XLO Xilio Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both XLO and GRID in my portfolio?

XLO and GRID have a correlation of 0.18, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XLO or GRID?

XLO has higher volatility (17.86%) compared to GRID (7.95%). In terms of maximum drawdown, XLO dropped -98.01% vs GRID's -40.56%.

Which has better risk-adjusted returns?

GRID currently has the higher Sharpe Ratio (2.67 vs -0.30), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.