Xilio Therapeutics, Inc. (XLO)

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The chart shows the growth of an initial investment of $10,000 in Xilio Therapeutics, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.

Xilio Therapeutics, Inc. (XLO) has returned -6.17% so far this year and -17.07% over the past 12 months.

Based on dividend-adjusted daily data since Oct 22, 2021, XLO's average daily return is -0.03%, while the average monthly return is -3.18%.

Historically, 41% of months were positive and 59% were negative. The best month was Oct 2024 with a return of +61.2%, while the worst month was Nov 2023 at -58.9%. The longest winning streak lasted 3 consecutive months, and the longest losing streak was 8 months.

On a daily basis, XLO closed higher 43% of trading days. The best single day was Feb 12, 2025 with a return of +125.3%, while the worst single day was Jun 2, 2025 at -34.6%.

Xilio Therapeutics, Inc. has an annualized alpha of -15.95%, beta of 0.93, and R² of 0.02 versus S&P 500 Index. Calculated based on daily prices since October 25, 2021.

• This stock participated in 119.11% of S&P 500 Index downside but only -105.05% of its upside — more exposed to losses than it benefited from rallies.
• R² of 0.02 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

XLO ranks 34 for risk / return — below 34% of stocks on our site. The returns aren't fully compensating for the risk involved. This isn't necessarily a dealbreaker, but factor it into your decision — especially if you're risk-averse.

The table below present risk-adjusted performance metrics for Xilio Therapeutics, Inc. (XLO) and compare them to a chosen benchmark (S&P 500 Index).

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the Xilio Therapeutics, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Xilio Therapeutics, Inc. was 98.01%, occurring on Dec 20, 2023. The portfolio has not yet recovered.

The current Xilio Therapeutics, Inc. drawdown is 97.61%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of Xilio Therapeutics, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how Xilio Therapeutics, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.