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Xilio Therapeutics, Inc. (XLO)
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN

US98422T1007

CUSIP

98422T100

IPO Date

Oct 22, 2021

Highlights

Market Cap

$48.51M

EPS (TTM)

-$0.65

Total Revenue (TTM)

$9.27M

Gross Profit (TTM)

$5.46M

EBITDA (TTM)

-$55.76M

Year Range

$0.62 - $1.70

Target Price

$4.00

Short %

3.44%

Short Ratio

0.50

Share Price Chart


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Xilio Therapeutics, Inc.

Popular comparisons:
XLO vs. XLK XLO vs. XLF XLO vs. NANC

Performance

Performance Chart


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S&P 500

Returns By Period

Xilio Therapeutics, Inc. (XLO) returned 0.93% year-to-date (YTD) and 2.98% over the past 12 months.


XLO

YTD

0.93%

1M

27.50%

6M

-4.56%

1Y

2.98%

3Y*

-33.24%

5Y*

N/A

10Y*

N/A

^GSPC (Benchmark)

YTD

0.52%

1M

6.32%

6M

-1.44%

1Y

12.25%

3Y*

12.45%

5Y*

14.20%

10Y*

10.84%

*Annualized

Monthly Returns

The table below presents the monthly returns of XLO, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
2025-26.18%28.51%-20.09%5.80%25.84%0.93%
202418.18%9.08%52.33%-3.70%3.85%-12.22%0.21%-9.68%-8.16%61.17%-14.17%-12.39%73.64%
202335.69%-1.10%-12.19%4.10%-7.58%-14.10%9.16%0.35%-26.48%3.79%-58.90%-38.89%-79.55%
2022-14.94%-13.45%-39.98%-50.07%-15.01%-2.67%-0.68%-22.76%29.91%-19.59%3.42%11.16%-83.19%
20214.94%-5.66%1.01%0.00%
Go deeper with the Portfolio Analysis tool — backtest performance, assess risk, compare to benchmarks, and more

Risk-Adjusted Performance

Risk-Adjusted Performance Rank

The current rank of XLO is 57, indicating average performance compared to other stocks on our website. Here’s a breakdown of how it compares using common performance measures.


The Risk-Adjusted Performance Rank of XLO is 5757
Overall Rank
The Sharpe Ratio Rank of XLO is 5050
Sharpe Ratio Rank
The Sortino Ratio Rank of XLO is 7575
Sortino Ratio Rank
The Omega Ratio Rank of XLO is 7272
Omega Ratio Rank
The Calmar Ratio Rank of XLO is 4545
Calmar Ratio Rank
The Martin Ratio Rank of XLO is 4545
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

Risk-Adjusted Performance Indicators

The charts below present risk-adjusted performance metrics for Xilio Therapeutics, Inc. (XLO) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.


The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

Xilio Therapeutics, Inc. Sharpe ratios as of May 30, 2025 (values are recalculated daily):

  • 1-Year: 0.02
  • All Time: -0.40

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns (including price changes and dividends).

The chart below shows the rolling Sharpe ratio of Xilio Therapeutics, Inc. compared to the selected benchmark. This view highlights how the investment's risk-adjusted performance has changed over time.


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Go to the full Sharpe Ratio tool to analyze any stock or portfolio. Customize time frames, set your own risk-free rate, and more

Dividends

Dividend History


Xilio Therapeutics, Inc. doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Xilio Therapeutics, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Xilio Therapeutics, Inc. was 98.01%, occurring on Dec 20, 2023. The portfolio has not yet recovered.

The current Xilio Therapeutics, Inc. drawdown is 96.16%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-98.01%Nov 17, 2021526Dec 20, 2023
-15.07%Nov 3, 20211Nov 3, 20211Nov 4, 20212
-7.66%Nov 5, 20211Nov 5, 20211Nov 8, 20212
-6.89%Nov 9, 20214Nov 12, 20212Nov 16, 20216
-2.19%Oct 27, 20211Oct 27, 20212Oct 29, 20213
Go to the full Drawdowns tool for more analysis options, including inflation-adjusted drawdowns, and more

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Xilio Therapeutics, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Earnings Per Share

The chart presents the Earnings Per Share (EPS) performance of Xilio Therapeutics, Inc., comparing actual results with analytics estimates. In the past quarter, the company did not meet analyst expectations for EPS, resulting in a surprise of -63.6%.


-25.00-20.00-15.00-10.00-5.000.0020212022202320242025
-0.18
-0.11
Actual
Estimate

Valuation

The Valuation section provides an overview of how Xilio Therapeutics, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for XLO relative to other companies in the Biotechnology industry. Currently, XLO has a P/S ratio of 5.2. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for XLO in comparison with other companies in the Biotechnology industry. Currently, XLO has a P/B value of 4.5. This P/B ratio is in line with the industry average, suggesting the stock is valued fairly in relation to its book value.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items