XLO vs. XLF

Last updated Apr 2, 2026

Compare and contrast key facts about Xilio Therapeutics, Inc. (XLO) and Financial Select Sector SPDR Fund (XLF).

XLF is a passively managed fund by State Street that tracks the performance of the Financial Select Sector Index. It was launched on Dec 16, 1998.

Performance

XLO vs. XLF - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Xilio Therapeutics, Inc. (XLO) and Financial Select Sector SPDR Fund (XLF). The values are adjusted to include any dividend payments, if applicable.

XLO vs. XLF - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
XLO Xilio Therapeutics, Inc.	-5.39%	-32.96%	73.64%	-79.55%	-83.19%	0.00%
XLF Financial Select Sector SPDR Fund	-9.27%	14.90%	30.56%	12.03%	-10.59%	-3.40%

Returns By Period

In the year-to-date period, XLO achieves a -5.39% return, which is significantly higher than XLF's -9.27% return.

XLO

• 1D: 0.83%
• 1M: 12.00%
• YTD: -5.39%
• 6M: -27.25%
• 1Y: -11.06%
• 3Y*: -42.40%
• 5Y*: —
• 10Y*: —

XLF

• 1D: 0.14%
• 1M: -3.13%
• YTD: -9.27%
• 6M: -6.60%
• 1Y: 0.91%
• 3Y*: 17.30%
• 5Y*: 9.37%
• 10Y*: 12.45%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

XLO vs. XLF — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XLO

XLO Risk / Return Rank: 37
XLO Sharpe Ratio Rank: 35
XLO Sortino Ratio Rank: 41
XLO Omega Ratio Rank: 43
XLO Calmar Ratio Rank: 31
XLO Martin Ratio Rank: 34

XLF

XLF Risk / Return Rank: 13
XLF Sharpe Ratio Rank: 13
XLF Sortino Ratio Rank: 12
XLF Omega Ratio Rank: 12
XLF Calmar Ratio Rank: 13
XLF Martin Ratio Rank: 13

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XLO vs. XLF - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Xilio Therapeutics, Inc. (XLO) and Financial Select Sector SPDR Fund (XLF). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	XLO	XLF	Difference
Sharpe ratio Return per unit of total volatility	-0.13	0.05	-0.17
Sortino ratio Return per unit of downside risk	0.47	0.19	+0.28
Omega ratio Gain probability vs. loss probability	1.07	1.03	+0.05
Calmar ratio Return relative to maximum drawdown	-0.29	0.05	-0.35
Martin ratio Return relative to average drawdown	-0.43	0.16	-0.59
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

XLO vs. XLF - Sharpe Ratio Comparison

The current XLO Sharpe Ratio is -0.13, which is lower than the XLF Sharpe Ratio of 0.05. The chart below compares the historical Sharpe Ratios of XLO and XLF, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	XLO	XLF	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.13	0.05	-0.17
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.50	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.56	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.42	0.20	-0.62

Correlation

The correlation between XLO and XLF is 0.17, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

XLO vs. XLF - Dividend Comparison

XLO has not paid dividends to shareholders, while XLF's dividend yield for the trailing twelve months is around 1.60%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
XLO Xilio Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XLF Financial Select Sector SPDR Fund	1.60%	1.31%	1.42%	1.71%	2.04%	1.63%	2.03%	1.87%	2.08%	1.48%	21.10%	1.95%

Drawdowns

XLO vs. XLF - Drawdown Comparison

The maximum XLO drawdown since its inception was -98.01%, which is greater than XLF's maximum drawdown of -82.69%. Use the drawdown chart below to compare losses from any high point for XLO and XLF.

Drawdown Indicators

	XLO	XLF	Difference
Max Drawdown Largest peak-to-trough decline	-98.01%	-82.69%	-15.32%
Max Drawdown (1Y) Largest decline over 1 year	-55.64%	-14.79%	-40.85%
Max Drawdown (5Y) Largest decline over 5 years	—	-25.81%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-42.86%	—
Current Drawdown Current decline from peak	-97.59%	-11.89%	-85.70%
Average Drawdown Average peak-to-trough decline	-88.38%	-20.10%	-68.28%
Ulcer Index Depth and duration of drawdowns from previous peaks	38.01%	4.96%	+33.05%

Volatility

XLO vs. XLF - Volatility Comparison

Xilio Therapeutics, Inc. (XLO) has a higher volatility of 16.94% compared to Financial Select Sector SPDR Fund (XLF) at 4.76%. This indicates that XLO's price experiences larger fluctuations and is considered to be riskier than XLF based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XLO	XLF	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.94%	4.76%	+12.18%
Volatility (6M) Calculated over the trailing 6-month period	35.59%	11.45%	+24.14%
Volatility (1Y) Calculated over the trailing 1-year period	88.82%	19.25%	+69.57%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	123.83%	18.69%	+105.14%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	123.83%	22.18%	+101.65%