XLO vs. XLF

Last updated Aug 1, 2026

XLO (Xilio Therapeutics, Inc.) is a stock, while XLF (State Street Financial Select Sector SPDR ETF) is Financials Equities fund tracking the Financial Select Sector Index. Over the past 3 years, XLO returned -37.77%/yr vs 19.11%/yr for XLF. Their 0.17 correlation means their historical movements had little consistent relationship.

Performance

XLO vs. XLF - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Xilio Therapeutics, Inc. (XLO) and State Street Financial Select Sector SPDR ETF (XLF). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XLO achieves a 1.64% return, which is significantly lower than XLF's 4.86% return.

XLO

• 1D: 0.33%
• 1M: -0.44%
• 6M: 9.38%
• YTD: 1.64%
• 1Y: 0.11%
• 3Y*: -37.77%
• 5Y*: —
• 10Y*: —
• ALL TIME*: -48.19%

XLF

• 1D: -0.11%
• 1M: 2.37%
• 6M: 7.47%
• YTD: 4.86%
• 1Y: 12.50%
• 3Y*: 19.11%
• 5Y*: 11.20%
• 10Y*: 13.69%
• ALL TIME*: 6.09%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
XLF State Street Financial Select Sector SPDR ETF	$1.84B	$1.93B	$1.92B
XLO Xilio Therapeutics, Inc.	$219.41K	$430.38K	$430.08K

XLO vs. XLF - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
XLO Xilio Therapeutics, Inc.	1.64%	-32.96%	73.64%	-79.55%	-83.19%	6.67%
XLF State Street Financial Select Sector SPDR ETF	4.86%	14.90%	30.56%	12.03%	-10.59%	-2.05%

Correlation

The correlation between XLO and XLF is 0.19, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.19
Correlation (3Y) Balances recent behavior with more history.	0.19
Correlation (All Time) Calculated using the full available price history since Oct 22, 2021	0.17

Return for Risk

XLO vs. XLF — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

XLO

XLO Risk / Return Rank: 44
XLO Sharpe Ratio Rank: 45
XLO Sortino Ratio Rank: 43
XLO Omega Ratio Rank: 42
XLO Calmar Ratio Rank: 45
XLO Martin Ratio Rank: 44

XLF

XLF Risk / Return Rank: 27
XLF Sharpe Ratio Rank: 29
XLF Sortino Ratio Rank: 28
XLF Omega Ratio Rank: 28
XLF Calmar Ratio Rank: 24
XLF Martin Ratio Rank: 24

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

XLO vs. XLF - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Xilio Therapeutics, Inc. (XLO) and State Street Financial Select Sector SPDR ETF (XLF). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XLO	XLF	Difference
Sharpe ratio: Return per unit of total volatility	0.01	0.71	-0.70
Sortino ratio: Return per unit of downside risk	0.37	1.05	-0.68
Omega ratio: Gain probability vs. loss probability	1.04	1.13	-0.09
Calmar ratio: Return relative to maximum drawdown	0.01	0.71	-0.70
Martin ratio: Return relative to average drawdown	0.01	1.80	-1.79

XLO vs. XLF - Sharpe Ratio Comparison

The current XLO Sharpe Ratio is 0.01, which is lower than the XLF Sharpe Ratio of 0.71. The chart below compares the historical Sharpe Ratios of XLO and XLF, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XLO vs. XLF - Drawdown Comparison

The maximum XLO drawdown since its inception was -98.01%, which is greater than XLF's maximum drawdown of -82.69%. Use the drawdown chart below to compare losses from any high point for XLO and XLF.

Drawdown Indicators

	XLO	XLF	Difference
Max Drawdown Largest peak-to-trough decline	-98.01%	-82.69%	-15.32%
Max Drawdown (1Y) Largest decline over 1 year	-40.90%	-14.79%	-26.11%
Max Drawdown (3Y) Largest decline over 3 years	-82.74%	-15.54%	-67.20%
Max Drawdown (5Y) Largest decline over 5 years	—	-25.81%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-42.86%	—
Current Drawdown Current decline from peak	-97.41%	-1.15%	-96.26%
Average Drawdown Average peak-to-trough decline	-88.94%	-19.92%	-69.02%
Ulcer Index Depth and duration of drawdowns from previous peaks	24.72%	5.79%	+18.93%

Volatility

XLO vs. XLF - Volatility Comparison

Xilio Therapeutics, Inc. (XLO) has a higher volatility of 9.92% compared to State Street Financial Select Sector SPDR ETF (XLF) at 4.07%. This indicates that XLO's price experiences larger fluctuations and is considered to be riskier than XLF based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XLO	XLF	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.92%	4.07%	+5.85%
Volatility (6M) Calculated over the trailing 6-month period	34.48%	11.10%	+23.38%
Volatility (1Y) Calculated over the trailing 1-year period	47.54%	14.77%	+32.77%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	120.02%	18.45%	+101.57%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	120.02%	22.08%	+97.94%

Dividends

XLO vs. XLF - Dividend Comparison

XLO has not paid dividends to shareholders, while XLF's dividend yield for the trailing twelve months is around 1.42%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
XLF State Street Financial Select Sector SPDR ETF	1.42%	1.31%	1.42%	1.71%	2.04%	1.63%	2.03%	1.87%	2.08%	1.48%	21.10%	1.95%
XLO Xilio Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both XLO and XLF in my portfolio?

XLO and XLF have a correlation of 0.19, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XLO or XLF?

XLO has higher volatility (9.92%) compared to XLF (4.07%). In terms of maximum drawdown, XLO dropped -98.01% vs XLF's -82.69%.

Which has better risk-adjusted returns?

XLF currently has the higher Sharpe Ratio (0.71 vs 0.01), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.