WDNA vs. XLVI

Last updated Jun 24, 2026

WDNA (WisdomTree BioRevolution Fund) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - WDNA is a Health & Biotech Equities fund tracking the WisdomTree BioRevolution Index, while XLVI is a Derivative Income fund actively managed by State Street. WDNA is passively managed, while XLVI is actively managed. A 0.56 correlation means they provide meaningful diversification when combined. WDNA charges 0.45%/yr vs 0.35%/yr for XLVI.

Performance

WDNA vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in WisdomTree BioRevolution Fund (WDNA) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, WDNA achieves a 13.32% return, which is significantly higher than XLVI's 2.50% return.

WDNA

• 1D: 0.49%
• 1M: 8.93%
• YTD: 13.32%
• 6M: 11.11%
• 1Y: 50.90%
• 3Y*: 5.47%
• 5Y*: -5.03%
• 10Y*: —

XLVI

• 1D: 1.53%
• 1M: 2.15%
• YTD: 2.50%
• 6M: 2.57%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

WDNA vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
WDNA WisdomTree BioRevolution Fund	13.32%	23.61%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	2.50%	12.41%

Correlation

The correlation between WDNA and XLVI is 0.56, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 30, 2025	0.56

WDNA vs. XLVI - Sectors Allocation Comparison

Sectors	WDNA	XLVI
Healthcare	85.0%	100.0%
Basic Materials	6.5%	-
Consumer Defensive	3.0%	-
Energy	1.1%	-
Communication Services	-	-
Consumer Cyclical	-	-
Financial Services	-	100.2%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

WDNA vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

WDNA

WDNA Risk / Return Rank: 66
WDNA Sharpe Ratio Rank: 65
WDNA Sortino Ratio Rank: 66
WDNA Omega Ratio Rank: 56
WDNA Calmar Ratio Rank: 85
WDNA Martin Ratio Rank: 59

XLVI

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

WDNA vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for WisdomTree BioRevolution Fund (WDNA) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	WDNA	XLVI	Difference
Sharpe ratio: Return per unit of total volatility	1.98	—	—
Sortino ratio: Return per unit of downside risk	2.81	—	—
Omega ratio: Gain probability vs. loss probability	1.32	—	—
Calmar ratio: Return relative to maximum drawdown	4.37	—	—
Martin ratio: Return relative to average drawdown	9.80	—	—

Drawdowns

WDNA vs. XLVI - Drawdown Comparison

The maximum WDNA drawdown since its inception was -58.87%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for WDNA and XLVI.

Drawdown Indicators

	WDNA	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-58.87%	-8.14%	-50.73%
Max Drawdown (1Y) Largest decline over 1 year	-11.70%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-38.25%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-58.87%	—	—
Current Drawdown Current decline from peak	-27.05%	-0.97%	-26.08%
Average Drawdown Average peak-to-trough decline	-35.56%	-1.94%	-33.62%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.21%	—	—

Volatility

Volatility by Period

	WDNA	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.39%	—	—
Volatility (6M) Calculated over the trailing 6-month period	16.98%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	25.90%	11.06%	+14.84%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.14%	11.06%	+14.08%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.06%	11.06%	+14.00%

WDNA vs. XLVI - Expense Ratio Comparison

WDNA has a 0.45% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

WDNA vs. XLVI - Dividend Comparison

WDNA's dividend yield for the trailing twelve months is around 4.03%, less than XLVI's 11.17% yield.

Position	TTM	2025	2024	2023	2022	2021
WDNA WisdomTree BioRevolution Fund	4.03%	4.57%	0.75%	0.80%	0.38%	0.10%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.17%	5.73%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both WDNA and XLVI in my portfolio?

WDNA and XLVI have a correlation of 0.56, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, WDNA or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, WDNA or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.45% for WDNA.

Which ETF pays a higher dividend yield, WDNA or XLVI?

XLVI has the higher dividend yield at 11.17%, compared with 4.03% for WDNA.

What is the main difference between WDNA and XLVI?

WDNA is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: WisdomTree and State Street. Their fees differ too: 0.45% for WDNA and 0.35% for XLVI.