VRTX vs. AMD
VRTX (Vertex Pharmaceuticals Incorporated) and AMD (Advanced Micro Devices, Inc.) are both stocks. VRTX operates in Biotechnology (Healthcare), while AMD operates in Semiconductors (Technology). Over the past 10 years, VRTX returned 17.15%/yr vs 60.93%/yr for AMD. At a 0.23 correlation, their price movements are largely independent.
Performance
VRTX vs. AMD - Performance Comparison
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Returns By Period
In the year-to-date period, VRTX achieves a -1.86% return, which is significantly lower than AMD's 138.87% return. Over the past 10 years, VRTX has underperformed AMD with an annualized return of 17.15%, while AMD has yielded a comparatively higher 60.93% annualized return.
VRTX
- 1D
- -0.03%
- 1M
- -1.22%
- YTD
- -1.86%
- 6M
- -1.57%
- 1Y
- -2.31%
- 3Y*
- 9.16%
- 5Y*
- 18.18%
- 10Y*
- 17.15%
AMD
- 1D
- 4.73%
- 1M
- 13.76%
- YTD
- 138.87%
- 6M
- 142.70%
- 1Y
- 340.40%
- 3Y*
- 60.16%
- 5Y*
- 44.46%
- 10Y*
- 60.93%
VRTX vs. AMD - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
VRTX Vertex Pharmaceuticals Incorporated | -1.86% | 12.58% | -1.03% | 40.90% | 31.50% | -7.08% | 7.94% | 32.13% | 10.58% | 103.42% |
AMD Advanced Micro Devices, Inc. | 138.87% | 77.30% | -18.06% | 127.59% | -54.99% | 56.91% | 99.98% | 148.43% | 79.57% | -9.35% |
Correlation
The correlation between VRTX and AMD is 0.07, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.07 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.12 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.14 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.23 |
Correlation (All Time) Calculated using the full available price history since Jul 24, 1991 | 0.23 |
The correlation between VRTX and AMD shifts across timeframes, from 0.07 (1 year) to 0.23 (all time), reflecting how their relationship changes across market environments.
Fundamentals
VRTX:
$114.03B
AMD:
$844.09B
VRTX:
$16.87
AMD:
$3.05
VRTX:
26.38
AMD:
167.75
VRTX:
2.19
AMD:
4.48
VRTX:
9.34
AMD:
22.43
VRTX:
4.31
AMD:
13.09
VRTX:
$12.26B
AMD:
$37.45B
VRTX:
$10.57B
AMD:
$18.83B
VRTX:
$5.19B
AMD:
$7.17B
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Return for Risk
VRTX vs. AMD — Risk / Return Rank
VRTX
AMD
VRTX vs. AMD - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Vertex Pharmaceuticals Incorporated (VRTX) and Advanced Micro Devices, Inc. (AMD). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| VRTX | AMD | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -5.11 | ||
| Sortino ratioReturn per unit of downside risk | -4.43 | ||
| Omega ratioGain probability vs. loss probability | 1.02 | 1.60 | -0.59 |
| Calmar ratioReturn relative to maximum drawdown | -0.14 | 12.04 | -12.18 |
| Martin ratioReturn relative to average drawdown | -0.29 | 24.74 | -25.03 |
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Drawdowns
VRTX vs. AMD - Drawdown Comparison
The maximum VRTX drawdown since its inception was -91.77%, roughly equal to the maximum AMD drawdown of -96.59%. Use the drawdown chart below to compare losses from any high point for VRTX and AMD.
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Drawdown Indicators
| VRTX | AMD | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.77% | -96.59% | +4.82% |
Max Drawdown (1Y)Largest decline over 1 year | -23.56% | -27.76% | +4.20% |
Max Drawdown (3Y)Largest decline over 3 years | -29.07% | -63.00% | +33.93% |
Max Drawdown (5Y)Largest decline over 5 years | -29.07% | -65.45% | +36.38% |
Max Drawdown (10Y)Largest decline over 10 years | -41.60% | -65.45% | +23.85% |
Current DrawdownCurrent decline from peak | -13.90% | -5.70% | -8.20% |
Average DrawdownAverage peak-to-trough decline | -37.73% | -56.65% | +18.92% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 11.30% | 13.48% | -2.18% |
Volatility
VRTX vs. AMD - Volatility Comparison
The current volatility for Vertex Pharmaceuticals Incorporated (VRTX) is 7.47%, while Advanced Micro Devices, Inc. (AMD) has a volatility of 22.71%. This indicates that VRTX experiences smaller price fluctuations and is considered to be less risky than AMD based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| VRTX | AMD | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 7.47% | 22.71% | -15.24% |
Volatility (6M)Calculated over the trailing 6-month period | 20.71% | 50.12% | -29.41% |
Volatility (1Y)Calculated over the trailing 1-year period | 34.13% | 66.74% | -32.61% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 28.53% | 55.71% | -27.18% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 32.82% | 56.99% | -24.17% |
Dividends
VRTX vs. AMD - Dividend Comparison
Neither VRTX nor AMD has paid dividends to shareholders.
Financials
VRTX vs. AMD - Financials Comparison
This section allows you to compare key financial metrics between Vertex Pharmaceuticals Incorporated and Advanced Micro Devices, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
VRTX vs. AMD - Profitability Comparison
VRTX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.59B and revenue of 2.99B. Therefore, the gross margin over that period was 86.9%.
AMD - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Advanced Micro Devices, Inc. reported a gross profit of 5.42B and revenue of 10.25B. Therefore, the gross margin over that period was 52.8%.
VRTX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.14B and revenue of 2.99B, resulting in an operating margin of 38.1%.
AMD - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Advanced Micro Devices, Inc. reported an operating income of 1.48B and revenue of 10.25B, resulting in an operating margin of 14.4%.
VRTX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.03B and revenue of 2.99B, resulting in a net margin of 34.5%.
AMD - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Advanced Micro Devices, Inc. reported a net income of 1.38B and revenue of 10.25B, resulting in a net margin of 13.5%.
Frequently Asked Questions
VRTX and AMD have a correlation of 0.07, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
AMD has higher volatility (22.71%) compared to VRTX (7.47%). In terms of maximum drawdown, VRTX dropped -91.77% vs AMD's -96.59%.
AMD currently has the higher Sharpe Ratio (5.01 vs -0.10), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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