TYRA vs. ALMS

Last updated Jun 3, 2026

TYRA (Tyra Biosciences, Inc.) and ALMS (Alumis Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past year, TYRA returned 198.54% vs 509.12% for ALMS. At a 0.23 correlation, their price movements are largely independent.

Performance

TYRA vs. ALMS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tyra Biosciences, Inc. (TYRA) and Alumis Inc (ALMS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TYRA achieves a 9.01% return, which is significantly lower than ALMS's 105.33% return.

TYRA

• 1D: -5.69%
• 1M: -15.80%
• YTD: 9.01%
• 6M: 37.00%
• 1Y: 198.54%
• 3Y*: 25.41%
• 5Y*: —
• 10Y*: —

ALMS

• 1D: -1.43%
• 1M: -20.41%
• YTD: 105.33%
• 6M: 170.45%
• 1Y: 509.12%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

TYRA vs. ALMS - Yearly Performance Comparison

	2026 (YTD)	2025	2024
TYRA Tyra Biosciences, Inc.	9.01%	89.14%	-13.07%
ALMS Alumis Inc	105.33%	24.17%	-40.90%

Correlation

The correlation between TYRA and ALMS is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.34
Correlation (All Time) Calculated using the full available price history since Jul 1, 2024	0.23

The correlation between TYRA and ALMS shifts across timeframes, from 0.23 (all time) to 0.34 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap TYRA : $1.77B ALMS : $2.51B
EPS TYRA : -$2.18 ALMS : -$2.31
PB Ratio TYRA : 4.57 ALMS : 4.42
Total Revenue (TTM) TYRA : $0.00 ALMS : $8.40M
Gross Profit (TTM) TYRA : -$132.00K ALMS : $5.79M
EBITDA (TTM) TYRA : -$129.69M ALMS : -$411.89M

Return for Risk

TYRA vs. ALMS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TYRA

TYRA Risk / Return Rank: 94
TYRA Sharpe Ratio Rank: 95
TYRA Sortino Ratio Rank: 94
TYRA Omega Ratio Rank: 90
TYRA Calmar Ratio Rank: 95
TYRA Martin Ratio Rank: 98

ALMS

ALMS Risk / Return Rank: 98
ALMS Sharpe Ratio Rank: 98
ALMS Sortino Ratio Rank: 98
ALMS Omega Ratio Rank: 97
ALMS Calmar Ratio Rank: 98
ALMS Martin Ratio Rank: 98

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TYRA vs. ALMS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tyra Biosciences, Inc. (TYRA) and Alumis Inc (ALMS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TYRA	ALMS	Difference
Sharpe ratio Return per unit of total volatility	3.27	4.24	-0.96
Sortino ratio Return per unit of downside risk	3.90	5.60	-1.71
Omega ratio Gain probability vs. loss probability	1.44	1.69	-0.25
Calmar ratio Return relative to maximum drawdown	7.59	14.25	-6.66
Martin ratio Return relative to average drawdown	30.54	36.74	-6.19
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TYRA vs. ALMS - Sharpe Ratio Comparison

The current TYRA Sharpe Ratio is 3.27, which is comparable to the ALMS Sharpe Ratio of 4.24. The chart below compares the historical Sharpe Ratios of TYRA and ALMS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TYRA	ALMS	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.27	4.24	-0.96
Sharpe Ratio (All Time) Calculated using the full available price history	0.03	0.20	-0.18

Drawdowns

TYRA vs. ALMS - Drawdown Comparison

The maximum TYRA drawdown since its inception was -83.22%, which is greater than ALMS's maximum drawdown of -78.95%. Use the drawdown chart below to compare losses from any high point for TYRA and ALMS.

Drawdown Indicators

	TYRA	ALMS	Difference
Max Drawdown Largest peak-to-trough decline	-83.22%	-78.95%	-4.27%
Max Drawdown (1Y) Largest decline over 1 year	-27.64%	-33.16%	+5.52%
Max Drawdown (3Y) Largest decline over 3 years	-75.32%	—	—
Current Drawdown Current decline from peak	-27.64%	-33.16%	+5.52%
Average Drawdown Average peak-to-trough decline	-51.08%	-38.17%	-12.91%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.87%	12.86%	-5.99%

Volatility

TYRA vs. ALMS - Volatility Comparison

Tyra Biosciences, Inc. (TYRA) and Alumis Inc (ALMS) have volatilities of 16.23% and 16.64%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TYRA	ALMS	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.23%	16.64%	-0.41%
Volatility (6M) Calculated over the trailing 6-month period	39.03%	89.41%	-50.38%
Volatility (1Y) Calculated over the trailing 1-year period	61.67%	121.43%	-59.76%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	81.88%	117.01%	-35.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	81.88%	117.01%	-35.13%

Dividends

TYRA vs. ALMS - Dividend Comparison

Neither TYRA nor ALMS has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TYRA and ALMS in my portfolio?

TYRA and ALMS have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TYRA or ALMS?

ALMS has higher volatility (16.64%) compared to TYRA (16.23%). In terms of maximum drawdown, TYRA dropped -83.22% vs ALMS's -78.95%.

Which has better risk-adjusted returns?

ALMS currently has the higher Sharpe Ratio (4.24 vs 3.27), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.