TYRA vs. AAOI

Last updated Jun 4, 2026

TYRA (Tyra Biosciences, Inc.) and AAOI (Applied Optoelectronics, Inc.) are both stocks. TYRA operates in Biotechnology (Healthcare), while AAOI operates in Semiconductors (Technology). Over the past 3 years, TYRA returned 25.46%/yr vs 332.83%/yr for AAOI. At a 0.22 correlation, their price movements are largely independent.

Performance

TYRA vs. AAOI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tyra Biosciences, Inc. (TYRA) and Applied Optoelectronics, Inc. (AAOI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TYRA achieves a 9.13% return, which is significantly lower than AAOI's 428.03% return.

TYRA

• 1D: 0.10%
• 1M: -18.36%
• YTD: 9.13%
• 6M: 32.21%
• 1Y: 197.31%
• 3Y*: 25.46%
• 5Y*: —
• 10Y*: —

AAOI

• 1D: -9.04%
• 1M: 6.41%
• YTD: 428.03%
• 6M: 617.62%
• 1Y: 998.27%
• 3Y*: 332.83%
• 5Y*: 85.24%
• 10Y*: 32.59%

*Multi-year figures are annualized to reflect compound growth (CAGR)

TYRA vs. AAOI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
TYRA Tyra Biosciences, Inc.	9.13%	89.14%	0.36%	82.24%	-45.98%	-45.88%
AAOI Applied Optoelectronics, Inc.	428.03%	-5.43%	90.79%	922.22%	-63.23%	-29.40%

Correlation

The correlation between TYRA and AAOI is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.12
Correlation (3Y) Calculated over the trailing 3-year period	0.21
Correlation (All Time) Calculated using the full available price history since Sep 16, 2021	0.22

The correlation between TYRA and AAOI shifts across timeframes, from 0.12 (1 year) to 0.22 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap TYRA : $1.77B AAOI : $13.99B
EPS TYRA : -$2.18 AAOI : -$0.65
PB Ratio TYRA : 4.57 AAOI : 12.65
Total Revenue (TTM) TYRA : $0.00 AAOI : $507.00M
Gross Profit (TTM) TYRA : -$132.00K AAOI : $150.29M
EBITDA (TTM) TYRA : -$129.69M AAOI : -$26.44M

Return for Risk

TYRA vs. AAOI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TYRA

TYRA Risk / Return Rank: 94
TYRA Sharpe Ratio Rank: 95
TYRA Sortino Ratio Rank: 94
TYRA Omega Ratio Rank: 90
TYRA Calmar Ratio Rank: 95
TYRA Martin Ratio Rank: 97

AAOI

AAOI Risk / Return Rank: 98
AAOI Sharpe Ratio Rank: 99
AAOI Sortino Ratio Rank: 96
AAOI Omega Ratio Rank: 94
AAOI Calmar Ratio Rank: 99
AAOI Martin Ratio Rank: 99

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TYRA vs. AAOI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tyra Biosciences, Inc. (TYRA) and Applied Optoelectronics, Inc. (AAOI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TYRA	AAOI	Difference
Sharpe ratio Return per unit of total volatility	3.25	7.37	-4.12
Sortino ratio Return per unit of downside risk	3.89	4.58	-0.70
Omega ratio Gain probability vs. loss probability	1.44	1.53	-0.09
Calmar ratio Return relative to maximum drawdown	7.23	21.18	-13.95
Martin ratio Return relative to average drawdown	28.10	59.65	-31.55
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TYRA vs. AAOI - Sharpe Ratio Comparison

The current TYRA Sharpe Ratio is 3.25, which is lower than the AAOI Sharpe Ratio of 7.37. The chart below compares the historical Sharpe Ratios of TYRA and AAOI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TYRA	AAOI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.25	7.37	-4.12
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.72	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.33	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.03	0.28	-0.26

Drawdowns

TYRA vs. AAOI - Drawdown Comparison

The maximum TYRA drawdown since its inception was -83.22%, smaller than the maximum AAOI drawdown of -98.49%. Use the drawdown chart below to compare losses from any high point for TYRA and AAOI.

Drawdown Indicators

	TYRA	AAOI	Difference
Max Drawdown Largest peak-to-trough decline	-83.22%	-98.49%	+15.27%
Max Drawdown (1Y) Largest decline over 1 year	-27.64%	-47.64%	+20.00%
Max Drawdown (3Y) Largest decline over 3 years	-75.32%	-77.17%	+1.85%
Max Drawdown (5Y) Largest decline over 5 years	—	-83.07%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-98.49%	—
Current Drawdown Current decline from peak	-27.57%	-17.49%	-10.08%
Average Drawdown Average peak-to-trough decline	-51.06%	-65.79%	+14.73%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.09%	16.88%	-9.79%

Volatility

TYRA vs. AAOI - Volatility Comparison

The current volatility for Tyra Biosciences, Inc. (TYRA) is 15.71%, while Applied Optoelectronics, Inc. (AAOI) has a volatility of 42.89%. This indicates that TYRA experiences smaller price fluctuations and is considered to be less risky than AAOI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TYRA	AAOI	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.71%	42.89%	-27.18%
Volatility (6M) Calculated over the trailing 6-month period	38.97%	107.15%	-68.18%
Volatility (1Y) Calculated over the trailing 1-year period	61.47%	137.01%	-75.54%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	81.84%	118.73%	-36.89%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	81.84%	97.94%	-16.10%

Dividends

TYRA vs. AAOI - Dividend Comparison

Neither TYRA nor AAOI has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TYRA and AAOI in my portfolio?

TYRA and AAOI have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TYRA or AAOI?

AAOI has higher volatility (42.89%) compared to TYRA (15.71%). In terms of maximum drawdown, TYRA dropped -83.22% vs AAOI's -98.49%.

Which has better risk-adjusted returns?

AAOI currently has the higher Sharpe Ratio (7.37 vs 3.25), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.