THNR vs. XLVI

Last updated Jun 4, 2026

THNR (Amplify Weight Loss Drug & Treatment ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - THNR is a Health & Biotech Equities fund tracking the VettaFi Weight Loss Drug & Treatment Index, while XLVI is a Derivative Income fund actively managed by State Street. THNR is passively managed, while XLVI is actively managed. A 0.68 correlation means they provide meaningful diversification when combined. THNR charges 0.59%/yr vs 0.35%/yr for XLVI.

Performance

THNR vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amplify Weight Loss Drug & Treatment ETF (THNR) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, THNR achieves a -5.67% return, which is significantly lower than XLVI's -0.67% return.

THNR

• 1D: -0.50%
• 1M: -3.61%
• YTD: -5.67%
• 6M: -4.62%
• 1Y: 8.57%
• 3Y*: —
• 5Y*: —
• 10Y*: —

XLVI

• 1D: 0.67%
• 1M: 2.30%
• YTD: -0.67%
• 6M: 0.76%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

THNR vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
THNR Amplify Weight Loss Drug & Treatment ETF	-5.67%	11.80%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	-0.67%	12.79%

Correlation

The correlation between THNR and XLVI is 0.68, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 31, 2025	0.68

THNR vs. XLVI - Sectors Allocation Comparison

Sectors	THNR	XLVI
Healthcare	97.7%	-
Financial Services	0.9%	100.6%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

THNR vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

THNR

THNR Risk / Return Rank: 17
THNR Sharpe Ratio Rank: 16
THNR Sortino Ratio Rank: 17
THNR Omega Ratio Rank: 16
THNR Calmar Ratio Rank: 18
THNR Martin Ratio Rank: 17

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

THNR vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amplify Weight Loss Drug & Treatment ETF (THNR) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	THNR	XLVI	Difference
Sharpe ratio: Return per unit of total volatility	0.45	—	—
Sortino ratio: Return per unit of downside risk	0.77	—	—
Omega ratio: Gain probability vs. loss probability	1.09	—	—
Calmar ratio: Return relative to maximum drawdown	0.71	—	—
Martin ratio: Return relative to average drawdown	1.62	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	THNR	XLVI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.45	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.10	1.33	-1.43

Drawdowns

THNR vs. XLVI - Drawdown Comparison

The maximum THNR drawdown since its inception was -32.51%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for THNR and XLVI.

Drawdown Indicators

	THNR	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-32.51%	-8.14%	-24.37%
Max Drawdown (1Y) Largest decline over 1 year	-12.06%	—	—
Current Drawdown Current decline from peak	-13.43%	-4.02%	-9.41%
Average Drawdown Average peak-to-trough decline	-12.25%	-1.95%	-10.30%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.31%	—	—

Volatility

Volatility by Period

	THNR	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.16%	—	—
Volatility (6M) Calculated over the trailing 6-month period	13.37%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	19.16%	10.94%	+8.22%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	19.35%	10.94%	+8.41%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	19.35%	10.94%	+8.41%

THNR vs. XLVI - Expense Ratio Comparison

THNR has a 0.59% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

THNR vs. XLVI - Dividend Comparison

THNR's dividend yield for the trailing twelve months is around 1.74%, less than XLVI's 11.53% yield.

Position	TTM	2025	2024
THNR Amplify Weight Loss Drug & Treatment ETF	1.74%	1.64%	0.98%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.53%	5.73%	0.00%

Frequently Asked Questions

Can I hold both THNR and XLVI in my portfolio?

THNR and XLVI have a correlation of 0.68, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, THNR or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, THNR or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.59% for THNR.

Which ETF pays a higher dividend yield, THNR or XLVI?

XLVI has the higher dividend yield at 11.53%, compared with 1.74% for THNR.

What is the main difference between THNR and XLVI?

THNR is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: Amplify and State Street. Their fees differ too: 0.59% for THNR and 0.35% for XLVI.