THNR vs. VOO

Last updated Jun 3, 2026

THNR (Amplify Weight Loss Drug & Treatment ETF) and VOO (Vanguard S&P 500 ETF) are both exchange-traded funds - THNR is a Health & Biotech Equities fund tracking the VettaFi Weight Loss Drug & Treatment Index, while VOO is a S&P 500 fund tracking the S&P 500 Index. Both are passively managed. Over the past year, THNR returned 9.10% vs 29.68% for VOO. At a 0.49 correlation, their price movements are largely independent. THNR charges 0.59%/yr vs 0.03%/yr for VOO.

Performance

THNR vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amplify Weight Loss Drug & Treatment ETF (THNR) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, THNR achieves a -5.20% return, which is significantly lower than VOO's 11.69% return.

THNR

• 1D: -1.47%
• 1M: -2.91%
• YTD: -5.20%
• 6M: -3.73%
• 1Y: 9.10%
• 3Y*: —
• 5Y*: —
• 10Y*: —

VOO

• 1D: 0.14%
• 1M: 5.39%
• YTD: 11.69%
• 6M: 12.11%
• 1Y: 29.68%
• 3Y*: 22.73%
• 5Y*: 14.26%
• 10Y*: 15.65%

*Multi-year figures are annualized to reflect compound growth (CAGR)

THNR vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024
THNR Amplify Weight Loss Drug & Treatment ETF	-5.20%	13.65%	-10.36%
VOO Vanguard S&P 500 ETF	11.69%	17.82%	11.40%

Correlation

The correlation between THNR and VOO is 0.48, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.48
Correlation (All Time) Calculated using the full available price history since May 22, 2024	0.50

THNR vs. VOO - Sectors Allocation Comparison

Sectors	THNR	VOO
Healthcare	97.7%	8.5%
Financial Services	0.9%	11.6%
Basic Materials	-	1.8%
Communication Services	-	11.3%
Consumer Cyclical	-	10.2%
Consumer Defensive	-	4.9%
Energy	-	3.5%
Industrials	-	8.3%
Real Estate	-	1.9%
Technology	-	35.7%
Utilities	-	2.4%

Return for Risk

THNR vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

THNR

THNR Risk / Return Rank: 16
THNR Sharpe Ratio Rank: 15
THNR Sortino Ratio Rank: 16
THNR Omega Ratio Rank: 15
THNR Calmar Ratio Rank: 18
THNR Martin Ratio Rank: 17

VOO

VOO Risk / Return Rank: 75
VOO Sharpe Ratio Rank: 77
VOO Sortino Ratio Rank: 75
VOO Omega Ratio Rank: 76
VOO Calmar Ratio Rank: 68
VOO Martin Ratio Rank: 80

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

THNR vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amplify Weight Loss Drug & Treatment ETF (THNR) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	THNR	VOO	Difference
Sharpe ratio Return per unit of total volatility	0.48	2.53	-2.05
Sortino ratio Return per unit of downside risk	0.81	3.43	-2.62
Omega ratio Gain probability vs. loss probability	1.10	1.46	-0.37
Calmar ratio Return relative to maximum drawdown	0.76	3.42	-2.66
Martin ratio Return relative to average drawdown	1.75	15.95	-14.20
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

THNR vs. VOO - Sharpe Ratio Comparison

The current THNR Sharpe Ratio is 0.48, which is lower than the VOO Sharpe Ratio of 2.53. The chart below compares the historical Sharpe Ratios of THNR and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	THNR	VOO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.48	2.53	-2.05
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.85	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.87	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.09	0.89	-0.98

Drawdowns

THNR vs. VOO - Drawdown Comparison

The maximum THNR drawdown since its inception was -32.51%, roughly equal to the maximum VOO drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for THNR and VOO.

Drawdown Indicators

	THNR	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-32.51%	-33.99%	+1.48%
Max Drawdown (1Y) Largest decline over 1 year	-12.06%	-8.90%	-3.16%
Max Drawdown (3Y) Largest decline over 3 years	—	-18.69%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-24.52%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-13.00%	0.00%	-13.00%
Average Drawdown Average peak-to-trough decline	-12.24%	-3.69%	-8.55%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.26%	1.91%	+3.35%

Volatility

THNR vs. VOO - Volatility Comparison

Amplify Weight Loss Drug & Treatment ETF (THNR) has a higher volatility of 5.16% compared to Vanguard S&P 500 ETF (VOO) at 2.74%. This indicates that THNR's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	THNR	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.16%	2.74%	+2.42%
Volatility (6M) Calculated over the trailing 6-month period	13.55%	8.88%	+4.67%
Volatility (1Y) Calculated over the trailing 1-year period	19.15%	11.78%	+7.37%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	19.37%	16.81%	+2.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	19.37%	18.01%	+1.36%

THNR vs. VOO - Expense Ratio Comparison

THNR has a 0.59% expense ratio, which is higher than VOO's 0.03% expense ratio.

Dividends

THNR vs. VOO - Dividend Comparison

THNR's dividend yield for the trailing twelve months is around 1.73%, more than VOO's 1.02% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
THNR Amplify Weight Loss Drug & Treatment ETF	1.73%	1.64%	0.98%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.02%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both THNR and VOO in my portfolio?

THNR and VOO have a correlation of 0.48, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, THNR or VOO?

THNR has higher volatility (5.16%) compared to VOO (2.74%). In terms of maximum drawdown, THNR dropped -32.51% vs VOO's -33.99%.

Which ETF is better, THNR or VOO?

On 1-year performance, VOO leads with 29.68% vs 9.10% for THNR. On fees, VOO is cheaper at 0.03% per year. On volatility, VOO has been the lower-risk option at 2.74%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, THNR or VOO?

Over the 1-year period, VOO has performed better with a 29.68% return vs 9.10%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, THNR or VOO?

VOO is cheaper with a 0.03% expense ratio, compared with 0.59% for THNR.

Which ETF pays a higher dividend yield, THNR or VOO?

THNR has the higher dividend yield at 1.73%, compared with 1.02% for VOO.

What is the main difference between THNR and VOO?

THNR is categorized as Health & Biotech Equities, while VOO is S&P 500. THNR tracks VettaFi Weight Loss Drug & Treatment Index, while VOO tracks S&P 500 Index. They also come from different issuers: Amplify and Vanguard. Their fees differ too: 0.59% for THNR and 0.03% for VOO.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (2.53 vs 0.48), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.