SKYE vs. KPTI
SKYE (Skye Bioscience, Inc) and KPTI (Karyopharm Therapeutics Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, SKYE returned -40.24%/yr vs -23.75%/yr for KPTI. At a 0.06 correlation, their price movements are largely independent.
Performance
SKYE vs. KPTI - Performance Comparison
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Returns By Period
In the year-to-date period, SKYE achieves a 2.71% return, which is significantly lower than KPTI's 15.49% return. Over the past 10 years, SKYE has underperformed KPTI with an annualized return of -40.24%, while KPTI has yielded a comparatively higher -23.75% annualized return.
SKYE
- 1D
- 5.02%
- 1M
- -10.75%
- YTD
- 2.71%
- 6M
- -36.36%
- 1Y
- -68.31%
- 3Y*
- -41.13%
- 5Y*
- -54.71%
- 10Y*
- -40.24%
KPTI
- 1D
- -6.39%
- 1M
- -1.62%
- YTD
- 15.49%
- 6M
- 44.31%
- 1Y
- 89.31%
- 3Y*
- -36.47%
- 5Y*
- -43.70%
- 10Y*
- -23.75%
SKYE vs. KPTI - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
SKYE Skye Bioscience, Inc | 2.71% | -73.51% | 4.04% | -32.84% | -68.85% | 30.00% | -69.47% | -67.25% | 163.16% | -49.67% |
KPTI Karyopharm Therapeutics Inc. | 15.49% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -19.25% | 104.59% | -2.40% | 2.13% |
Correlation
The correlation between SKYE and KPTI is 0.08, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.08 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.09 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.08 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.06 |
Correlation (All Time) Calculated using the full available price history since Apr 6, 2015 | 0.06 |
Fundamentals
SKYE:
$30.55M
KPTI:
$210.08M
SKYE:
-$1.45
KPTI:
-$13.00
SKYE:
$0.00
KPTI:
$151.12M
SKYE:
-$180.01K
KPTI:
$145.13M
SKYE:
$10.92M
KPTI:
-$93.05M
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Return for Risk
SKYE vs. KPTI — Risk / Return Rank
SKYE
KPTI
SKYE vs. KPTI - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Skye Bioscience, Inc (SKYE) and Karyopharm Therapeutics Inc. (KPTI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| SKYE | KPTI | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.55 | ||
| Sortino ratioReturn per unit of downside risk | -2.40 | ||
| Omega ratioGain probability vs. loss probability | 0.94 | 1.22 | -0.28 |
| Calmar ratioReturn relative to maximum drawdown | -0.78 | 1.86 | -2.64 |
| Martin ratioReturn relative to average drawdown | -1.04 | 4.59 | -5.63 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| SKYE | KPTI | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.59 | 0.95 | -1.55 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.42 | -0.46 | +0.04 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.29 | -0.28 | -0.02 |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.36 | -0.27 | -0.09 |
Drawdowns
SKYE vs. KPTI - Drawdown Comparison
The maximum SKYE drawdown since its inception was -99.96%, roughly equal to the maximum KPTI drawdown of -99.50%. Use the drawdown chart below to compare losses from any high point for SKYE and KPTI.
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Drawdown Indicators
| SKYE | KPTI | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.96% | -99.50% | -0.46% |
Max Drawdown (1Y)Largest decline over 1 year | -87.85% | -48.36% | -39.49% |
Max Drawdown (3Y)Largest decline over 3 years | -96.79% | -89.32% | -7.47% |
Max Drawdown (5Y)Largest decline over 5 years | -98.66% | -98.36% | -0.30% |
Max Drawdown (10Y)Largest decline over 10 years | -99.83% | -99.15% | -0.68% |
Current DrawdownCurrent decline from peak | -99.94% | -98.80% | -1.14% |
Average DrawdownAverage peak-to-trough decline | -94.95% | -75.28% | -19.67% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 65.76% | 19.53% | +46.23% |
Volatility
SKYE vs. KPTI - Volatility Comparison
Skye Bioscience, Inc (SKYE) has a higher volatility of 28.64% compared to Karyopharm Therapeutics Inc. (KPTI) at 24.86%. This indicates that SKYE's price experiences larger fluctuations and is considered to be riskier than KPTI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SKYE | KPTI | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 28.64% | 24.86% | +3.78% |
Volatility (6M)Calculated over the trailing 6-month period | 63.38% | 62.32% | +1.06% |
Volatility (1Y)Calculated over the trailing 1-year period | 115.33% | 94.32% | +21.01% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 130.81% | 94.91% | +35.90% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 137.31% | 86.51% | +50.80% |
Dividends
SKYE vs. KPTI - Dividend Comparison
Neither SKYE nor KPTI has paid dividends to shareholders.
Financials
SKYE vs. KPTI - Financials Comparison
This section allows you to compare key financial metrics between Skye Bioscience, Inc and Karyopharm Therapeutics Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
SKYE and KPTI have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
SKYE has higher volatility (28.64%) compared to KPTI (24.86%). In terms of maximum drawdown, SKYE dropped -99.96% vs KPTI's -99.50%.
KPTI currently has the higher Sharpe Ratio (0.95 vs -0.59), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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