KPTI vs. SKYE
KPTI (Karyopharm Therapeutics Inc.) and SKYE (Skye Bioscience, Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, KPTI returned -23.75%/yr vs -40.24%/yr for SKYE. At a 0.06 correlation, their price movements are largely independent.
Performance
KPTI vs. SKYE - Performance Comparison
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Returns By Period
In the year-to-date period, KPTI achieves a 15.49% return, which is significantly higher than SKYE's 2.71% return. Over the past 10 years, KPTI has outperformed SKYE with an annualized return of -23.75%, while SKYE has yielded a comparatively lower -40.24% annualized return.
KPTI
- 1D
- -6.39%
- 1M
- -1.62%
- YTD
- 15.49%
- 6M
- 44.31%
- 1Y
- 89.31%
- 3Y*
- -36.47%
- 5Y*
- -43.70%
- 10Y*
- -23.75%
SKYE
- 1D
- 5.02%
- 1M
- -10.75%
- YTD
- 2.71%
- 6M
- -36.36%
- 1Y
- -68.31%
- 3Y*
- -41.13%
- 5Y*
- -54.71%
- 10Y*
- -40.24%
KPTI vs. SKYE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | 15.49% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -19.25% | 104.59% | -2.40% | 2.13% |
SKYE Skye Bioscience, Inc | 2.71% | -73.51% | 4.04% | -32.84% | -68.85% | 30.00% | -69.47% | -67.25% | 163.16% | -49.67% |
Correlation
The correlation between KPTI and SKYE is 0.08, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.08 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.09 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.08 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.06 |
Correlation (All Time) Calculated using the full available price history since Apr 6, 2015 | 0.06 |
Fundamentals
KPTI:
$210.08M
SKYE:
$30.55M
KPTI:
-$13.00
SKYE:
-$1.45
KPTI:
$151.12M
SKYE:
$0.00
KPTI:
$145.13M
SKYE:
-$180.01K
KPTI:
-$93.05M
SKYE:
$10.92M
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Return for Risk
KPTI vs. SKYE — Risk / Return Rank
KPTI
SKYE
KPTI vs. SKYE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Skye Bioscience, Inc (SKYE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| KPTI | SKYE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.55 | ||
| Sortino ratioReturn per unit of downside risk | +2.40 | ||
| Omega ratioGain probability vs. loss probability | 1.22 | 0.94 | +0.28 |
| Calmar ratioReturn relative to maximum drawdown | 1.86 | -0.78 | +2.64 |
| Martin ratioReturn relative to average drawdown | 4.59 | -1.04 | +5.63 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| KPTI | SKYE | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.95 | -0.59 | +1.55 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.46 | -0.42 | -0.04 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.28 | -0.29 | +0.02 |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.27 | -0.36 | +0.09 |
Drawdowns
KPTI vs. SKYE - Drawdown Comparison
The maximum KPTI drawdown since its inception was -99.50%, roughly equal to the maximum SKYE drawdown of -99.96%. Use the drawdown chart below to compare losses from any high point for KPTI and SKYE.
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Drawdown Indicators
| KPTI | SKYE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.50% | -99.96% | +0.46% |
Max Drawdown (1Y)Largest decline over 1 year | -48.36% | -87.85% | +39.49% |
Max Drawdown (3Y)Largest decline over 3 years | -89.32% | -96.79% | +7.47% |
Max Drawdown (5Y)Largest decline over 5 years | -98.36% | -98.66% | +0.30% |
Max Drawdown (10Y)Largest decline over 10 years | -99.15% | -99.83% | +0.68% |
Current DrawdownCurrent decline from peak | -98.80% | -99.94% | +1.14% |
Average DrawdownAverage peak-to-trough decline | -75.28% | -94.95% | +19.67% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 19.53% | 65.76% | -46.23% |
Volatility
KPTI vs. SKYE - Volatility Comparison
The current volatility for Karyopharm Therapeutics Inc. (KPTI) is 24.86%, while Skye Bioscience, Inc (SKYE) has a volatility of 28.64%. This indicates that KPTI experiences smaller price fluctuations and is considered to be less risky than SKYE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| KPTI | SKYE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 24.86% | 28.64% | -3.78% |
Volatility (6M)Calculated over the trailing 6-month period | 62.32% | 63.38% | -1.06% |
Volatility (1Y)Calculated over the trailing 1-year period | 94.32% | 115.33% | -21.01% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 94.91% | 130.81% | -35.90% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 86.51% | 137.31% | -50.80% |
Dividends
KPTI vs. SKYE - Dividend Comparison
Neither KPTI nor SKYE has paid dividends to shareholders.
Financials
KPTI vs. SKYE - Financials Comparison
This section allows you to compare key financial metrics between Karyopharm Therapeutics Inc. and Skye Bioscience, Inc. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
KPTI and SKYE have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
SKYE has higher volatility (28.64%) compared to KPTI (24.86%). In terms of maximum drawdown, KPTI dropped -99.50% vs SKYE's -99.96%.
KPTI currently has the higher Sharpe Ratio (0.95 vs -0.59), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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