KPTI vs. KEEL

Last updated Aug 1, 2026

KPTI (Karyopharm Therapeutics Inc.) and KEEL (Keel Infrastructure Corporation) are both stocks. KPTI operates in Biotechnology (Healthcare), while KEEL operates in Capital Markets (Financial Services). Over the past 5 years, KPTI returned -56.62%/yr vs -1.07%/yr for KEEL. Their 0.17 correlation means their historical movements had little consistent relationship.

Performance

KPTI vs. KEEL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Karyopharm Therapeutics Inc. (KPTI) and Keel Infrastructure Corporation (KEEL). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, KPTI achieves a -73.91% return, which is significantly lower than KEEL's 68.94% return.

KPTI

• 1D: -72.61%
• 1M: -80.00%
• 6M: -70.55%
• YTD: -73.91%
• 1Y: -51.15%
• 3Y*: -58.57%
• 5Y*: -56.62%
• 10Y*: -32.96%
• ALL TIME*: -32.15%

KEEL

• 1D: -1.98%
• 1M: -13.51%
• 6M: 69.66%
• YTD: 68.94%
• 1Y: 242.24%
• 3Y*: 30.65%
• 5Y*: -1.07%
• 10Y*: —
• ALL TIME*: 13.26%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
KEEL Keel Infrastructure Corporation	$141.39M	$139.45M	$235.87M
KPTI Karyopharm Therapeutics Inc.	$12.61M	$7.85M	$5.63M

KPTI vs. KEEL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
KPTI Karyopharm Therapeutics Inc.	-73.91%	-27.45%	-21.82%	-74.56%	-47.12%	-58.46%	-19.25%	104.59%	-48.29%
KEEL Keel Infrastructure Corporation	68.94%	57.72%	-48.80%	561.36%	-91.29%	165.79%	397.66%	-27.96%	-64.19%

Correlation

The correlation between KPTI and KEEL is 0.11, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.11
Correlation (3Y) Balances recent behavior with more history.	0.14
Correlation (5Y) Shows whether the relationship held over a longer period.	0.23
Correlation (All Time) Calculated using the full available price history since Aug 28, 2018	0.17

The correlation between KPTI and KEEL shifts across timeframes, from 0.11 (1 year) to 0.23 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap KPTI : $43.51M KEEL : $2.40B
EPS KPTI : -$11.39 KEEL : -$0.51
PS Ratio KPTI : 0.22 KEEL : 9.59
Total Revenue (TTM) KPTI : $151.12M KEEL : $229.28M
Gross Profit (TTM) KPTI : $145.13M KEEL : -$18.90M
EBITDA (TTM) KPTI : -$93.05M KEEL : -$149.60M

Return for Risk

KPTI vs. KEEL — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

KPTI

KPTI Risk / Return Rank: 26
KPTI Sharpe Ratio Rank: 25
KPTI Sortino Ratio Rank: 41
KPTI Omega Ratio Rank: 43
KPTI Calmar Ratio Rank: 22
KPTI Martin Ratio Rank: 0

KEEL

KEEL Risk / Return Rank: 86
KEEL Sharpe Ratio Rank: 90
KEEL Sortino Ratio Rank: 89
KEEL Omega Ratio Rank: 86
KEEL Calmar Ratio Rank: 86
KEEL Martin Ratio Rank: 78

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

KPTI vs. KEEL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Keel Infrastructure Corporation (KEEL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	KPTI	KEEL	Difference
Sharpe ratio: Return per unit of total volatility	-0.42	1.89	-2.31
Sortino ratio: Return per unit of downside risk	0.32	2.65	-2.32
Omega ratio: Gain probability vs. loss probability	1.05	1.31	-0.26
Calmar ratio: Return relative to maximum drawdown	-0.61	2.94	-3.55
Martin ratio: Return relative to average drawdown	-2.42	4.77	-7.19

KPTI vs. KEEL - Sharpe Ratio Comparison

The current KPTI Sharpe Ratio is -0.42, which is lower than the KEEL Sharpe Ratio of 1.89. The chart below compares the historical Sharpe Ratios of KPTI and KEEL, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

KPTI vs. KEEL - Drawdown Comparison

The maximum KPTI drawdown since its inception was -99.73%, roughly equal to the maximum KEEL drawdown of -95.72%. Use the drawdown chart below to compare losses from any high point for KPTI and KEEL.

Drawdown Indicators

	KPTI	KEEL	Difference
Max Drawdown Largest peak-to-trough decline	-99.73%	-95.72%	-4.01%
Max Drawdown (1Y) Largest decline over 1 year	-82.01%	-73.65%	-8.36%
Max Drawdown (3Y) Largest decline over 3 years	-92.73%	-81.04%	-11.69%
Max Drawdown (5Y) Largest decline over 5 years	-99.11%	-95.72%	-3.39%
Max Drawdown (10Y) Largest decline over 10 years	-99.54%	—	—
Current Drawdown Current decline from peak	-99.73%	-55.24%	-44.49%
Average Drawdown Average peak-to-trough decline	-75.59%	-67.10%	-8.49%
Ulcer Index Depth and duration of drawdowns from previous peaks	20.49%	45.31%	-24.82%

Volatility

KPTI vs. KEEL - Volatility Comparison

Karyopharm Therapeutics Inc. (KPTI) has a higher volatility of 131.26% compared to Keel Infrastructure Corporation (KEEL) at 42.99%. This indicates that KPTI's price experiences larger fluctuations and is considered to be riskier than KEEL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	KPTI	KEEL	Difference
Volatility (1M) Calculated over the trailing 1-month period	131.26%	42.99%	+88.27%
Volatility (6M) Calculated over the trailing 6-month period	144.90%	78.09%	+66.81%
Volatility (1Y) Calculated over the trailing 1-year period	117.57%	114.73%	+2.84%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	101.03%	105.23%	-4.20%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	89.78%	289.01%	-199.23%

Dividends

KPTI vs. KEEL - Dividend Comparison

Neither KPTI nor KEEL has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both KPTI and KEEL in my portfolio?

KPTI and KEEL have a correlation of 0.11, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, KPTI or KEEL?

KPTI has higher volatility (131.26%) compared to KEEL (42.99%). In terms of maximum drawdown, KPTI dropped -99.73% vs KEEL's -95.72%.

Which has better risk-adjusted returns?

KEEL currently has the higher Sharpe Ratio (1.89 vs -0.42), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.