WVE vs. VOO
WVE (Wave Life Sciences Ltd.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 10 years, WVE returned -11.28%/yr vs 15.14%/yr for VOO. Their 0.26 correlation means their historical movements had little consistent relationship.
Performance
WVE vs. VOO - Performance Comparison
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Returns By Period
In the year-to-date period, WVE achieves a -67.59% return, which is significantly lower than VOO's 10.16% return. Over the past 10 years, WVE has underperformed VOO with an annualized return of -11.28%, while VOO has yielded a comparatively higher 15.14% annualized return.
WVE
- 1D
- -4.34%
- 1M
- -11.98%
- 6M
- -57.42%
- YTD
- -67.59%
- 1Y
- -36.15%
- 3Y*
- 8.03%
- 5Y*
- 0.00%
- 10Y*
- -11.28%
- ALL TIME*
- -10.00%
VOO
- 1D
- 0.71%
- 1M
- 0.26%
- 6M
- 8.58%
- YTD
- 10.16%
- 1Y
- 21.58%
- 3Y*
- 19.42%
- 5Y*
- 12.83%
- 10Y*
- 15.14%
- ALL TIME*
- 14.78%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $3.82B | $3.78B | $5.44B | |
| $12.78M | $14.44M | $20.78M |
WVE vs. VOO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
WVE Wave Life Sciences Ltd. | -67.59% | 37.43% | 144.95% | -27.86% | 122.93% | -60.10% | -1.81% | -80.93% | 19.77% | 34.23% |
VOO Vanguard S&P 500 ETF | 10.16% | 17.82% | 24.98% | 26.32% | -18.17% | 28.79% | 18.32% | 31.37% | -4.50% | 21.77% |
Correlation
The correlation between WVE and VOO is 0.23, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.23 |
Correlation (3Y) Balances recent behavior with more history. | 0.27 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.29 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.27 |
Correlation (All Time) Calculated using the full available price history since Nov 11, 2015 | 0.26 |
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Return for Risk
WVE vs. VOO — Risk / Return Rank
WVE
VOO
WVE vs. VOO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Wave Life Sciences Ltd. (WVE) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| WVE | VOO | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.72 | ||
| Sortino ratioReturn per unit of downside risk | -1.28 | ||
| Omega ratioGain probability vs. loss probability | 1.13 | 1.28 | -0.14 |
| Calmar ratioReturn relative to maximum drawdown | -0.43 | 2.21 | -2.64 |
| Martin ratioReturn relative to average drawdown | -0.68 | 9.44 | -10.11 |
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Drawdowns
WVE vs. VOO - Drawdown Comparison
The maximum WVE drawdown since its inception was -97.77%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for WVE and VOO.
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Drawdown Indicators
| WVE | VOO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.77% | -33.99% | -63.78% |
Max Drawdown (1Y)Largest decline over 1 year | -74.14% | -8.90% | -65.24% |
Max Drawdown (3Y)Largest decline over 3 years | -74.14% | -18.69% | -55.45% |
Max Drawdown (5Y)Largest decline over 5 years | -81.08% | -24.52% | -56.56% |
Max Drawdown (10Y)Largest decline over 10 years | -97.77% | -33.99% | -63.78% |
Current DrawdownCurrent decline from peak | -90.02% | -1.38% | -88.64% |
Average DrawdownAverage peak-to-trough decline | -65.12% | -3.67% | -61.45% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 47.26% | 2.08% | +45.18% |
Volatility
WVE vs. VOO - Volatility Comparison
Wave Life Sciences Ltd. (WVE) has a higher volatility of 12.84% compared to Vanguard S&P 500 ETF (VOO) at 3.54%. This indicates that WVE's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| WVE | VOO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 12.84% | 3.54% | +9.30% |
Volatility (6M)Calculated over the trailing 6-month period | 77.83% | 10.10% | +67.73% |
Volatility (1Y)Calculated over the trailing 1-year period | 168.16% | 12.82% | +155.34% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 114.49% | 16.93% | +97.56% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 98.68% | 18.01% | +80.67% |
Dividends
WVE vs. VOO - Dividend Comparison
WVE has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.07%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
VOO Vanguard S&P 500 ETF | 1.07% | 1.13% | 1.24% | 1.46% | 1.69% | 1.25% | 1.54% | 1.88% | 2.06% | 1.78% | 2.02% | 2.10% |
WVE Wave Life Sciences Ltd. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Frequently Asked Questions
WVE and VOO have a correlation of 0.23, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
WVE has higher volatility (12.84%) compared to VOO (3.54%). In terms of maximum drawdown, WVE dropped -97.77% vs VOO's -33.99%.
VOO currently has the higher Sharpe Ratio (1.53 vs -0.19), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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