IDNA vs. MSTZ
IDNA (iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund) and MSTZ (T-REX 2X Inverse MSTR Daily Target ETF) are both exchange-traded funds - IDNA is a Health & Biotech Equities fund tracking the NYSE FactSet Global Genomics and Immuno Biopharma Index, while MSTZ is a Inverse Equities fund actively managed by REX. IDNA is passively managed, while MSTZ is actively managed. Over the past year, IDNA returned 57.08% vs 282.56% for MSTZ. At a correlation of -0.28, they often move in opposite directions. IDNA charges 0.47%/yr vs 1.05%/yr for MSTZ.
Performance
IDNA vs. MSTZ - Performance Comparison
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Returns By Period
In the year-to-date period, IDNA achieves a 26.34% return, which is significantly higher than MSTZ's -23.27% return.
IDNA
- 1D
- -1.79%
- 1M
- 11.15%
- 6M
- 19.72%
- YTD
- 26.34%
- 1Y
- 57.08%
- 3Y*
- 12.75%
- 5Y*
- -6.42%
- 10Y*
- —
MSTZ
- 1D
- 5.07%
- 1M
- 46.38%
- 6M
- -9.68%
- YTD
- -23.27%
- 1Y
- 282.56%
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
IDNA vs. MSTZ - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | |
|---|---|---|---|
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund | 26.34% | 17.26% | -8.98% |
MSTZ T-REX 2X Inverse MSTR Daily Target ETF | -23.27% | -38.95% | -94.43% |
Correlation
The correlation between IDNA and MSTZ is -0.30, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | -0.30 |
Correlation (All Time) Calculated using the full available price history since Sep 18, 2024 | -0.28 |
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Return for Risk
IDNA vs. MSTZ — Risk / Return Rank
IDNA
MSTZ
IDNA vs. MSTZ - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) and T-REX 2X Inverse MSTR Daily Target ETF (MSTZ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| IDNA | MSTZ | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.35 | ||
| Sortino ratioReturn per unit of downside risk | +0.68 | ||
| Omega ratioGain probability vs. loss probability | 1.36 | 1.32 | +0.04 |
| Calmar ratioReturn relative to maximum drawdown | 5.38 | 3.35 | +2.03 |
| Martin ratioReturn relative to average drawdown | 14.96 | 6.53 | +8.43 |
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Drawdowns
IDNA vs. MSTZ - Drawdown Comparison
The maximum IDNA drawdown since its inception was -68.26%, smaller than the maximum MSTZ drawdown of -99.38%. Use the drawdown chart below to compare losses from any high point for IDNA and MSTZ.
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Drawdown Indicators
| IDNA | MSTZ | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -68.26% | -99.38% | +31.12% |
Max Drawdown (1Y)Largest decline over 1 year | -10.66% | -84.89% | +74.23% |
Max Drawdown (3Y)Largest decline over 3 years | -29.46% | — | — |
Max Drawdown (5Y)Largest decline over 5 years | -68.26% | — | — |
Current DrawdownCurrent decline from peak | -37.71% | -97.39% | +59.68% |
Average DrawdownAverage peak-to-trough decline | -36.28% | -94.53% | +58.25% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 3.83% | 43.51% | -39.68% |
Volatility
IDNA vs. MSTZ - Volatility Comparison
The current volatility for iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) is 7.23%, while T-REX 2X Inverse MSTR Daily Target ETF (MSTZ) has a volatility of 56.56%. This indicates that IDNA experiences smaller price fluctuations and is considered to be less risky than MSTZ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| IDNA | MSTZ | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 7.23% | 56.56% | -49.33% |
Volatility (6M)Calculated over the trailing 6-month period | 18.68% | 135.11% | -116.43% |
Volatility (1Y)Calculated over the trailing 1-year period | 25.27% | 148.53% | -123.26% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 28.52% | 171.02% | -142.50% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 29.51% | 171.02% | -141.51% |
IDNA vs. MSTZ - Expense Ratio Comparison
IDNA has a 0.47% expense ratio, which is lower than MSTZ's 1.05% expense ratio.
Dividends
IDNA vs. MSTZ - Dividend Comparison
IDNA's dividend yield for the trailing twelve months is around 0.85%, while MSTZ has not paid dividends to shareholders.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund | 0.85% | 1.18% | 0.98% | 1.04% | 0.54% | 0.70% | 0.26% | 0.80% |
MSTZ T-REX 2X Inverse MSTR Daily Target ETF | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Frequently Asked Questions
IDNA and MSTZ have a correlation of -0.30, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
MSTZ has higher volatility (56.56%) compared to IDNA (7.23%). In terms of maximum drawdown, IDNA dropped -68.26% vs MSTZ's -99.38%.
On 1-year performance, MSTZ leads with 282.56% vs 57.08% for IDNA. On fees, IDNA is cheaper at 0.47% per year. On volatility, IDNA has been the lower-risk option at 7.23%. The better choice depends on whether you care most about return, fees, risk, or income.
Over the 1-year period, MSTZ has performed better with a 282.56% return vs 57.08%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.
IDNA is cheaper with a 0.47% expense ratio, compared with 1.05% for MSTZ.
IDNA has the higher dividend yield at 0.85%, compared with 0.00% for MSTZ.
IDNA is categorized as Health & Biotech Equities, while MSTZ is Inverse Equities. They also come from different issuers: iShares and REX. Their fees differ too: 0.47% for IDNA and 1.05% for MSTZ.
IDNA currently has the higher Sharpe Ratio (2.27 vs 1.92), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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