CRBU vs. VB

Last updated Jun 6, 2026

CRBU (Caribou Biosciences, Inc.) is a stock, while VB (Vanguard Small-Cap ETF) is Small Cap Blend Equities fund tracking the CRSP US Small Cap Index. Over the past 3 years, CRBU returned -26.42%/yr vs 15.96%/yr for VB. At a 0.48 correlation, their price movements are largely independent.

Performance

CRBU vs. VB - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Caribou Biosciences, Inc. (CRBU) and Vanguard Small-Cap ETF (VB). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CRBU achieves a 20.75% return, which is significantly higher than VB's 12.15% return.

CRBU

• 1D: -7.02%
• 1M: -1.54%
• YTD: 20.75%
• 6M: 1.05%
• 1Y: 76.15%
• 3Y*: -26.42%
• 5Y*: —
• 10Y*: —

VB

• 1D: -2.44%
• 1M: -0.91%
• YTD: 12.15%
• 6M: 11.58%
• 1Y: 26.81%
• 3Y*: 15.96%
• 5Y*: 6.73%
• 10Y*: 10.96%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CRBU vs. VB - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CRBU Caribou Biosciences, Inc.	20.75%	0.00%	-72.25%	-8.76%	-58.38%	-7.54%
VB Vanguard Small-Cap ETF	12.15%	8.87%	14.17%	18.22%	-17.51%	3.42%

Correlation

The correlation between CRBU and VB is 0.48, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.48
Correlation (3Y) Calculated over the trailing 3-year period	0.48
Correlation (All Time) Calculated using the full available price history since Jul 26, 2021	0.48

Return for Risk

CRBU vs. VB — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CRBU

CRBU Risk / Return Rank: 68
CRBU Sharpe Ratio Rank: 70
CRBU Sortino Ratio Rank: 71
CRBU Omega Ratio Rank: 66
CRBU Calmar Ratio Rank: 69
CRBU Martin Ratio Rank: 65

VB

VB Risk / Return Rank: 53
VB Sharpe Ratio Rank: 48
VB Sortino Ratio Rank: 49
VB Omega Ratio Rank: 46
VB Calmar Ratio Rank: 62
VB Martin Ratio Rank: 63

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CRBU vs. VB - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Caribou Biosciences, Inc. (CRBU) and Vanguard Small-Cap ETF (VB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CRBU	VB	Difference
Sharpe ratio: Return per unit of total volatility	0.92	1.64	-0.72
Sortino ratio: Return per unit of downside risk	1.76	2.35	-0.59
Omega ratio: Gain probability vs. loss probability	1.20	1.29	-0.09
Calmar ratio: Return relative to maximum drawdown	1.50	3.00	-1.50
Martin ratio: Return relative to average drawdown	2.64	11.02	-8.38
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CRBU vs. VB - Sharpe Ratio Comparison

The current CRBU Sharpe Ratio is 0.92, which is lower than the VB Sharpe Ratio of 1.64. The chart below compares the historical Sharpe Ratios of CRBU and VB, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CRBU	VB	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.92	1.64	-0.72
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.33	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.51	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.41	0.44	-0.85

Drawdowns

CRBU vs. VB - Drawdown Comparison

The maximum CRBU drawdown since its inception was -97.58%, which is greater than VB's maximum drawdown of -59.56%. Use the drawdown chart below to compare losses from any high point for CRBU and VB.

Drawdown Indicators

	CRBU	VB	Difference
Max Drawdown Largest peak-to-trough decline	-97.58%	-59.56%	-38.02%
Max Drawdown (1Y) Largest decline over 1 year	-51.06%	-8.98%	-42.08%
Max Drawdown (3Y) Largest decline over 3 years	-91.12%	-25.36%	-65.76%
Max Drawdown (5Y) Largest decline over 5 years	—	-28.15%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-42.05%	—
Current Drawdown Current decline from peak	-93.66%	-2.44%	-91.22%
Average Drawdown Average peak-to-trough decline	-79.30%	-8.43%	-70.87%
Ulcer Index Depth and duration of drawdowns from previous peaks	28.96%	2.44%	+26.52%

Volatility

CRBU vs. VB - Volatility Comparison

Caribou Biosciences, Inc. (CRBU) has a higher volatility of 22.95% compared to Vanguard Small-Cap ETF (VB) at 4.84%. This indicates that CRBU's price experiences larger fluctuations and is considered to be riskier than VB based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CRBU	VB	Difference
Volatility (1M) Calculated over the trailing 1-month period	22.95%	4.84%	+18.11%
Volatility (6M) Calculated over the trailing 6-month period	49.58%	11.98%	+37.60%
Volatility (1Y) Calculated over the trailing 1-year period	83.41%	16.45%	+66.96%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	86.84%	20.77%	+66.07%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	86.84%	21.43%	+65.41%

Dividends

CRBU vs. VB - Dividend Comparison

CRBU has not paid dividends to shareholders, while VB's dividend yield for the trailing twelve months is around 1.21%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CRBU Caribou Biosciences, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VB Vanguard Small-Cap ETF	1.21%	1.33%	1.30%	1.55%	1.59%	1.24%	1.14%	1.39%	1.67%	1.35%	1.50%	1.48%

Frequently Asked Questions

Can I hold both CRBU and VB in my portfolio?

CRBU and VB have a correlation of 0.48, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CRBU or VB?

CRBU has higher volatility (22.95%) compared to VB (4.84%). In terms of maximum drawdown, CRBU dropped -97.58% vs VB's -59.56%.

Which has better risk-adjusted returns?

VB currently has the higher Sharpe Ratio (1.64 vs 0.92), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.