CRBU vs. SDGR

Last updated Aug 1, 2026

CRBU (Caribou Biosciences, Inc.) and SDGR (Schrodinger, Inc.) are both stocks. Both are in the Healthcare sector — CRBU in Biotechnology, SDGR in Health Information Services. Over the past 5 years, CRBU returned -38.20%/yr vs -25.88%/yr for SDGR. Their 0.47 correlation means their historical movements had little consistent relationship.

Performance

CRBU vs. SDGR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Caribou Biosciences, Inc. (CRBU) and Schrodinger, Inc. (SDGR). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CRBU achieves a -8.18% return, which is significantly higher than SDGR's -15.32% return.

CRBU

• 1D: -3.31%
• 1M: -19.78%
• 6M: 3.55%
• YTD: -8.18%
• 1Y: -25.13%
• 3Y*: -41.55%
• 5Y*: -38.20%
• 10Y*: —
• ALL TIME*: -39.13%

SDGR

• 1D: -1.37%
• 1M: -10.31%
• 6M: 8.38%
• YTD: -15.32%
• 1Y: -22.48%
• 3Y*: -33.86%
• 5Y*: -25.88%
• 10Y*: —
• ALL TIME*: -8.01%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
CRBU Caribou Biosciences, Inc.	$1.81M	$3.07M	$3.70M
SDGR Schrodinger, Inc.	$12.37M	$14.56M	$19.33M

CRBU vs. SDGR - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CRBU Caribou Biosciences, Inc.	-8.18%	0.00%	-72.25%	-8.76%	-58.38%	-14.50%
SDGR Schrodinger, Inc.	-15.32%	-7.31%	-46.12%	91.55%	-46.34%	-50.30%

Correlation

The correlation between CRBU and SDGR is 0.37, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.37
Correlation (3Y) Balances recent behavior with more history.	0.44
Correlation (5Y) Shows whether the relationship held over a longer period.	0.48
Correlation (All Time) Calculated using the full available price history since Jul 23, 2021	0.47

The correlation between CRBU and SDGR shifts across timeframes, from 0.37 (1 year) to 0.48 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap CRBU : $144.80M SDGR : $1.13B
EPS CRBU : -$1.41 SDGR : -$1.40
PS Ratio CRBU : 15.68 SDGR : 4.38
PB Ratio CRBU : 1.37 SDGR : 3.57
Total Revenue (TTM) CRBU : $8.81M SDGR : $254.91M
Gross Profit (TTM) CRBU : $7.49M SDGR : $141.04M
EBITDA (TTM) CRBU : -$115.23M SDGR : -$85.22M

Return for Risk

CRBU vs. SDGR — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

CRBU

CRBU Risk / Return Rank: 28
CRBU Sharpe Ratio Rank: 27
CRBU Sortino Ratio Rank: 30
CRBU Omega Ratio Rank: 31
CRBU Calmar Ratio Rank: 24
CRBU Martin Ratio Rank: 26

SDGR

SDGR Risk / Return Rank: 24
SDGR Sharpe Ratio Rank: 22
SDGR Sortino Ratio Rank: 23
SDGR Omega Ratio Rank: 24
SDGR Calmar Ratio Rank: 26
SDGR Martin Ratio Rank: 28

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

CRBU vs. SDGR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Caribou Biosciences, Inc. (CRBU) and Schrodinger, Inc. (SDGR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CRBU	SDGR	Difference
Sharpe ratio: Return per unit of total volatility	-0.38	-0.50	+0.12
Sortino ratio: Return per unit of downside risk	-0.11	-0.45	+0.33
Omega ratio: Gain probability vs. loss probability	0.99	0.95	+0.04
Calmar ratio: Return relative to maximum drawdown	-0.55	-0.50	-0.05
Martin ratio: Return relative to average drawdown	-0.89	-0.82	-0.07

CRBU vs. SDGR - Sharpe Ratio Comparison

The current CRBU Sharpe Ratio is -0.38, which is comparable to the SDGR Sharpe Ratio of -0.50. The chart below compares the historical Sharpe Ratios of CRBU and SDGR, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CRBU vs. SDGR - Drawdown Comparison

The maximum CRBU drawdown since its inception was -97.58%, which is greater than SDGR's maximum drawdown of -90.21%. Use the drawdown chart below to compare losses from any high point for CRBU and SDGR.

Drawdown Indicators

	CRBU	SDGR	Difference
Max Drawdown Largest peak-to-trough decline	-97.58%	-90.21%	-7.37%
Max Drawdown (1Y) Largest decline over 1 year	-51.06%	-50.84%	-0.22%
Max Drawdown (3Y) Largest decline over 3 years	-91.12%	-72.25%	-18.87%
Max Drawdown (5Y) Largest decline over 5 years	-97.58%	-83.96%	-13.62%
Current Drawdown Current decline from peak	-95.18%	-86.61%	-8.57%
Average Drawdown Average peak-to-trough decline	-79.71%	-64.53%	-15.18%
Ulcer Index Depth and duration of drawdowns from previous peaks	31.64%	31.07%	+0.57%

Volatility

CRBU vs. SDGR - Volatility Comparison

Caribou Biosciences, Inc. (CRBU) has a higher volatility of 13.75% compared to Schrodinger, Inc. (SDGR) at 9.40%. This indicates that CRBU's price experiences larger fluctuations and is considered to be riskier than SDGR based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CRBU	SDGR	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.75%	9.40%	+4.35%
Volatility (6M) Calculated over the trailing 6-month period	48.91%	37.40%	+11.51%
Volatility (1Y) Calculated over the trailing 1-year period	74.25%	51.61%	+22.64%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	86.14%	63.43%	+22.71%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	86.04%	69.50%	+16.54%

Dividends

CRBU vs. SDGR - Dividend Comparison

Neither CRBU nor SDGR has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CRBU and SDGR in my portfolio?

CRBU and SDGR have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CRBU or SDGR?

CRBU has higher volatility (13.75%) compared to SDGR (9.40%). In terms of maximum drawdown, CRBU dropped -97.58% vs SDGR's -90.21%.

Which has better risk-adjusted returns?

CRBU currently has the higher Sharpe Ratio (-0.38 vs -0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.