CRBU vs. PROK

Last updated Jun 5, 2026

CRBU (Caribou Biosciences, Inc.) and PROK (ProKidney Corp.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, CRBU returned -24.35%/yr vs -46.57%/yr for PROK. At a 0.28 correlation, their price movements are largely independent.

Performance

CRBU vs. PROK - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Caribou Biosciences, Inc. (CRBU) and ProKidney Corp. (PROK). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CRBU achieves a 29.87% return, which is significantly higher than PROK's -17.41% return.

CRBU

• 1D: 3.25%
• 1M: 6.99%
• YTD: 29.87%
• 6M: 6.44%
• 1Y: 82.74%
• 3Y*: -24.35%
• 5Y*: —
• 10Y*: —

PROK

• 1D: 6.94%
• 1M: -3.65%
• YTD: -17.41%
• 6M: -28.02%
• 1Y: 134.47%
• 3Y*: -46.57%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CRBU vs. PROK - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
CRBU Caribou Biosciences, Inc.	29.87%	0.00%	-72.25%	-8.76%	-6.69%
PROK ProKidney Corp.	-17.41%	32.54%	-5.06%	-74.05%	-20.51%

Correlation

The correlation between CRBU and PROK is 0.37, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.37
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (All Time) Calculated using the full available price history since Jul 13, 2022	0.28

Fundamentals

Market Cap CRBU : $197.95M PROK : $262.56B
EPS CRBU : -$1.41 PROK : -$0.00
PS Ratio CRBU : 22.09 PROK : 74.04K
PB Ratio CRBU : 1.94 PROK : 997.94
Total Revenue (TTM) CRBU : $8.81M PROK : $889.00K
Gross Profit (TTM) CRBU : $7.49M PROK : -$2.18M
EBITDA (TTM) CRBU : -$115.23M PROK : -$112.46M

Return for Risk

CRBU vs. PROK — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CRBU

CRBU Risk / Return Rank: 69
CRBU Sharpe Ratio Rank: 71
CRBU Sortino Ratio Rank: 72
CRBU Omega Ratio Rank: 67
CRBU Calmar Ratio Rank: 70
CRBU Martin Ratio Rank: 66

PROK

PROK Risk / Return Rank: 77
PROK Sharpe Ratio Rank: 51
PROK Sortino Ratio Rank: 99
PROK Omega Ratio Rank: 98
PROK Calmar Ratio Rank: 74
PROK Martin Ratio Rank: 64

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CRBU vs. PROK - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Caribou Biosciences, Inc. (CRBU) and ProKidney Corp. (PROK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CRBU	PROK	Difference
Sharpe ratio: Return per unit of total volatility	1.00	0.26	+0.74
Sortino ratio: Return per unit of downside risk	1.84	6.88	-5.04
Omega ratio: Gain probability vs. loss probability	1.21	1.79	-0.58
Calmar ratio: Return relative to maximum drawdown	1.63	1.93	-0.30
Martin ratio: Return relative to average drawdown	2.87	2.55	+0.33
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CRBU vs. PROK - Sharpe Ratio Comparison

The current CRBU Sharpe Ratio is 1.00, which is higher than the PROK Sharpe Ratio of 0.26. The chart below compares the historical Sharpe Ratios of CRBU and PROK, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CRBU	PROK	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.00	0.26	+0.74
Sharpe Ratio (All Time) Calculated using the full available price history	-0.40	-0.12	-0.29

Drawdowns

CRBU vs. PROK - Drawdown Comparison

The maximum CRBU drawdown since its inception was -97.58%, roughly equal to the maximum PROK drawdown of -96.29%. Use the drawdown chart below to compare losses from any high point for CRBU and PROK.

Drawdown Indicators

	CRBU	PROK	Difference
Max Drawdown Largest peak-to-trough decline	-97.58%	-96.29%	-1.29%
Max Drawdown (1Y) Largest decline over 1 year	-51.06%	-70.08%	+19.02%
Max Drawdown (3Y) Largest decline over 3 years	-91.12%	-96.09%	+4.97%
Current Drawdown Current decline from peak	-93.18%	-86.57%	-6.61%
Average Drawdown Average peak-to-trough decline	-79.28%	-65.10%	-14.18%
Ulcer Index Depth and duration of drawdowns from previous peaks	28.89%	52.99%	-24.10%

Volatility

CRBU vs. PROK - Volatility Comparison

Caribou Biosciences, Inc. (CRBU) has a higher volatility of 21.68% compared to ProKidney Corp. (PROK) at 19.88%. This indicates that CRBU's price experiences larger fluctuations and is considered to be riskier than PROK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CRBU	PROK	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.68%	19.88%	+1.80%
Volatility (6M) Calculated over the trailing 6-month period	49.33%	51.38%	-2.05%
Volatility (1Y) Calculated over the trailing 1-year period	83.40%	525.53%	-442.13%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	86.82%	284.71%	-197.89%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	86.82%	284.71%	-197.89%

Dividends

CRBU vs. PROK - Dividend Comparison

Neither CRBU nor PROK has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CRBU and PROK in my portfolio?

CRBU and PROK have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CRBU or PROK?

CRBU has higher volatility (21.68%) compared to PROK (19.88%). In terms of maximum drawdown, CRBU dropped -97.58% vs PROK's -96.29%.

Which has better risk-adjusted returns?

CRBU currently has the higher Sharpe Ratio (1.00 vs 0.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.