AYTU vs. DNN

Last updated Jun 5, 2026

AYTU (Aytu BioPharma, Inc.) and DNN (Denison Mines Corp) are both stocks. AYTU operates in Drug Manufacturers - Specialty & Generic (Healthcare), while DNN operates in Uranium (Energy). Over the past 5 years, AYTU returned -54.28%/yr vs 20.01%/yr for DNN. At a 0.13 correlation, their price movements are largely independent.

Performance

AYTU vs. DNN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Aytu BioPharma, Inc. (AYTU) and Denison Mines Corp (DNN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AYTU achieves a -18.28% return, which is significantly lower than DNN's 28.20% return.

AYTU

• 1D: 1.67%
• 1M: -17.32%
• YTD: -18.28%
• 6M: -5.14%
• 1Y: 33.64%
• 3Y*: 6.68%
• 5Y*: -54.28%
• 10Y*: —

DNN

• 1D: -0.29%
• 1M: -5.28%
• YTD: 28.20%
• 6M: 20.07%
• 1Y: 106.67%
• 3Y*: 42.04%
• 5Y*: 20.01%
• 10Y*: 20.24%

*Multi-year figures are annualized to reflect compound growth (CAGR)

AYTU vs. DNN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
AYTU Aytu BioPharma, Inc.	-18.28%	52.94%	-40.14%	-24.87%	-86.00%	-77.42%	-38.35%	22.41%	-98.22%	-88.85%
DNN Denison Mines Corp	28.20%	47.78%	1.69%	53.91%	-16.06%	111.75%	54.05%	-9.48%	-15.64%	-21.43%

Correlation

The correlation between AYTU and DNN is 0.21, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.21
Correlation (3Y) Calculated over the trailing 3-year period	0.11
Correlation (5Y) Calculated over the trailing 5-year period	0.16
Correlation (All Time) Calculated using the full available price history since Feb 2, 2017	0.13

The correlation between AYTU and DNN shifts across timeframes, from 0.11 (3 years) to 0.21 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap AYTU : $22.34M DNN : $3.08B
EPS AYTU : -$2.91 DNN : -$0.28
PS Ratio AYTU : 0.44 DNN : 708.32
PB Ratio AYTU : 0.64 DNN : 11.81
Total Revenue (TTM) AYTU : $56.60M DNN : $4.34M
Gross Profit (TTM) AYTU : $36.14M DNN : -$12.87M
EBITDA (TTM) AYTU : -$27.34M DNN : -$155.36M

Return for Risk

AYTU vs. DNN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AYTU

AYTU Risk / Return Rank: 61
AYTU Sharpe Ratio Rank: 59
AYTU Sortino Ratio Rank: 61
AYTU Omega Ratio Rank: 60
AYTU Calmar Ratio Rank: 61
AYTU Martin Ratio Rank: 62

DNN

DNN Risk / Return Rank: 83
DNN Sharpe Ratio Rank: 85
DNN Sortino Ratio Rank: 81
DNN Omega Ratio Rank: 77
DNN Calmar Ratio Rank: 86
DNN Martin Ratio Rank: 84

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AYTU vs. DNN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Aytu BioPharma, Inc. (AYTU) and Denison Mines Corp (DNN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AYTU	DNN	Difference
Sharpe ratio: Return per unit of total volatility	0.52	1.78	-1.25
Sortino ratio: Return per unit of downside risk	1.27	2.37	-1.10
Omega ratio: Gain probability vs. loss probability	1.16	1.28	-0.12
Calmar ratio: Return relative to maximum drawdown	0.95	3.64	-2.68
Martin ratio: Return relative to average drawdown	2.28	8.32	-6.04
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AYTU vs. DNN - Sharpe Ratio Comparison

The current AYTU Sharpe Ratio is 0.52, which is lower than the DNN Sharpe Ratio of 1.78. The chart below compares the historical Sharpe Ratios of AYTU and DNN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	AYTU	DNN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.52	1.78	-1.25
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.64	0.32	-0.95
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.32	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.36	-0.07	-0.29

Drawdowns

AYTU vs. DNN - Drawdown Comparison

The maximum AYTU drawdown since its inception was -100.00%, roughly equal to the maximum DNN drawdown of -98.96%. Use the drawdown chart below to compare losses from any high point for AYTU and DNN.

Drawdown Indicators

	AYTU	DNN	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-98.96%	-1.04%
Max Drawdown (1Y) Largest decline over 1 year	-35.47%	-29.50%	-5.97%
Max Drawdown (3Y) Largest decline over 3 years	-70.24%	-52.48%	-17.76%
Max Drawdown (5Y) Largest decline over 5 years	-99.12%	-55.66%	-43.46%
Max Drawdown (10Y) Largest decline over 10 years	—	-75.90%	—
Current Drawdown Current decline from peak	-100.00%	-82.31%	-17.69%
Average Drawdown Average peak-to-trough decline	-95.14%	-85.07%	-10.07%
Ulcer Index Depth and duration of drawdowns from previous peaks	14.80%	12.87%	+1.93%

Volatility

AYTU vs. DNN - Volatility Comparison

The current volatility for Aytu BioPharma, Inc. (AYTU) is 12.62%, while Denison Mines Corp (DNN) has a volatility of 16.66%. This indicates that AYTU experiences smaller price fluctuations and is considered to be less risky than DNN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AYTU	DNN	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.62%	16.66%	-4.04%
Volatility (6M) Calculated over the trailing 6-month period	33.45%	45.01%	-11.56%
Volatility (1Y) Calculated over the trailing 1-year period	64.79%	60.48%	+4.31%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	85.63%	63.36%	+22.27%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	188.27%	64.18%	+124.09%

Dividends

AYTU vs. DNN - Dividend Comparison

Neither AYTU nor DNN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both AYTU and DNN in my portfolio?

AYTU and DNN have a correlation of 0.21, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AYTU or DNN?

DNN has higher volatility (16.66%) compared to AYTU (12.62%). In terms of maximum drawdown, AYTU dropped -100.00% vs DNN's -98.96%.

Which has better risk-adjusted returns?

DNN currently has the higher Sharpe Ratio (1.78 vs 0.52), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.