AYTU vs. CVKD

Last updated Aug 1, 2026

AYTU (Aytu BioPharma, Inc.) and CVKD (Cadrenal Therapeutics Inc. Common Stock) are both stocks. Both are in the Healthcare sector — AYTU in Drug Manufacturers - Specialty & Generic, CVKD in Biotechnology. Over the past 3 years, AYTU returned 7.01%/yr vs -46.42%/yr for CVKD. Their 0.12 correlation means their historical movements had little consistent relationship.

Performance

AYTU vs. CVKD - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Aytu BioPharma, Inc. (AYTU) and Cadrenal Therapeutics Inc. Common Stock (CVKD). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AYTU achieves a -14.23% return, which is significantly higher than CVKD's -70.35% return.

AYTU

• 1D: 3.72%
• 1M: 3.24%
• 6M: -14.23%
• YTD: -14.23%
• 1Y: -7.08%
• 3Y*: 7.01%
• 5Y*: -51.06%
• 10Y*: —
• ALL TIME*: -67.05%

CVKD

• 1D: -3.83%
• 1M: -44.17%
• 6M: -71.08%
• YTD: -70.35%
• 1Y: -80.54%
• 3Y*: -46.42%
• 5Y*: —
• 10Y*: —
• ALL TIME*: -65.49%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
AYTU Aytu BioPharma, Inc.	$55.01K	$54.55K	$81.73K
CVKD Cadrenal Therapeutics Inc. Common Stock	$110.41K	$169.96K	$278.30K

AYTU vs. CVKD - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
AYTU Aytu BioPharma, Inc.	-14.23%	52.94%	-40.14%	-18.86%
CVKD Cadrenal Therapeutics Inc. Common Stock	-70.35%	-53.21%	30.56%	-87.04%

Correlation

The correlation between AYTU and CVKD is 0.19, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.19
Correlation (3Y) Balances recent behavior with more history.	0.15
Correlation (All Time) Calculated using the full available price history since Jan 20, 2023	0.12

Fundamentals

Market Cap AYTU : $23.94M CVKD : $6.23M
EPS AYTU : -$2.55 CVKD : -$5.05
PB Ratio AYTU : 0.67 CVKD : 1.46
Total Revenue (TTM) AYTU : $56.60M CVKD : $0.00
Gross Profit (TTM) AYTU : $36.14M CVKD : -$5.92K
EBITDA (TTM) AYTU : -$27.34M CVKD : -$13.32M

Return for Risk

AYTU vs. CVKD — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

AYTU

AYTU Risk / Return Rank: 37
AYTU Sharpe Ratio Rank: 37
AYTU Sortino Ratio Rank: 37
AYTU Omega Ratio Rank: 37
AYTU Calmar Ratio Rank: 36
AYTU Martin Ratio Rank: 35

CVKD

CVKD Risk / Return Rank: 6
CVKD Sharpe Ratio Rank: 9
CVKD Sortino Ratio Rank: 5
CVKD Omega Ratio Rank: 7
CVKD Calmar Ratio Rank: 6
CVKD Martin Ratio Rank: 4

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

AYTU vs. CVKD - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Aytu BioPharma, Inc. (AYTU) and Cadrenal Therapeutics Inc. Common Stock (CVKD). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	AYTU	CVKD	Difference
Sharpe ratio: Return per unit of total volatility	-0.16	-0.80	+0.64
Sortino ratio: Return per unit of downside risk	0.15	-1.61	+1.77
Omega ratio: Gain probability vs. loss probability	1.02	0.82	+0.20
Calmar ratio: Return relative to maximum drawdown	-0.24	-0.94	+0.70
Martin ratio: Return relative to average drawdown	-0.49	-1.61	+1.12

AYTU vs. CVKD - Sharpe Ratio Comparison

The current AYTU Sharpe Ratio is -0.16, which is higher than the CVKD Sharpe Ratio of -0.80. The chart below compares the historical Sharpe Ratios of AYTU and CVKD, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

AYTU vs. CVKD - Drawdown Comparison

The maximum AYTU drawdown since its inception was -100.00%, roughly equal to the maximum CVKD drawdown of -97.70%. Use the drawdown chart below to compare losses from any high point for AYTU and CVKD.

Drawdown Indicators

	AYTU	CVKD	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-97.70%	-2.30%
Max Drawdown (1Y) Largest decline over 1 year	-35.47%	-86.13%	+50.66%
Max Drawdown (3Y) Largest decline over 3 years	-70.24%	-92.78%	+22.54%
Max Drawdown (5Y) Largest decline over 5 years	-98.74%	—	—
Current Drawdown Current decline from peak	-100.00%	-97.65%	-2.35%
Average Drawdown Average peak-to-trough decline	-95.33%	-85.16%	-10.17%
Ulcer Index Depth and duration of drawdowns from previous peaks	17.59%	50.14%	-32.55%

Volatility

AYTU vs. CVKD - Volatility Comparison

The current volatility for Aytu BioPharma, Inc. (AYTU) is 10.72%, while Cadrenal Therapeutics Inc. Common Stock (CVKD) has a volatility of 26.48%. This indicates that AYTU experiences smaller price fluctuations and is considered to be less risky than CVKD based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AYTU	CVKD	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.72%	26.48%	-15.76%
Volatility (6M) Calculated over the trailing 6-month period	31.58%	70.68%	-39.10%
Volatility (1Y) Calculated over the trailing 1-year period	54.31%	100.94%	-46.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	85.24%	101.96%	-16.72%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	186.78%	101.96%	+84.82%

Dividends

AYTU vs. CVKD - Dividend Comparison

Neither AYTU nor CVKD has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both AYTU and CVKD in my portfolio?

AYTU and CVKD have a correlation of 0.19, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AYTU or CVKD?

CVKD has higher volatility (26.48%) compared to AYTU (10.72%). In terms of maximum drawdown, AYTU dropped -100.00% vs CVKD's -97.70%.

Which has better risk-adjusted returns?

AYTU currently has the higher Sharpe Ratio (-0.16 vs -0.80), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.