AYTU vs. CVKD

Last updated Apr 2, 2026

Compare and contrast key facts about Aytu BioPharma, Inc. (AYTU) and Cadrenal Therapeutics Inc. Common Stock (CVKD).

Performance

AYTU vs. CVKD - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Aytu BioPharma, Inc. (AYTU) and Cadrenal Therapeutics Inc. Common Stock (CVKD). The values are adjusted to include any dividend payments, if applicable.

AYTU vs. CVKD - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
AYTU Aytu BioPharma, Inc.	1.54%	52.94%	-40.14%	-19.77%
CVKD Cadrenal Therapeutics Inc. Common Stock	-27.73%	-53.21%	30.56%	-82.04%

Fundamentals

Market Cap AYTU : $26.50M CVKD : $9.77M
EPS AYTU : -$2.02 CVKD : -$5.10
PB Ratio AYTU : 1.87 CVKD : 3.57
Total Revenue (TTM) AYTU : $62.64M CVKD : $0.00
Gross Profit (TTM) AYTU : $41.34M CVKD : -$5.92K
EBITDA (TTM) AYTU : -$17.24M CVKD : -$13.32M

Returns By Period

In the year-to-date period, AYTU achieves a 1.54% return, which is significantly higher than CVKD's -27.73% return.

AYTU

• 1D: -3.30%
• 1M: -0.00%
• YTD: 1.54%
• 6M: 41.18%
• 1Y: 127.59%
• 3Y*: 5.63%
• 5Y*: -55.49%
• 10Y*: —

CVKD

• 1D: -4.30%
• 1M: -42.96%
• YTD: -27.73%
• 6M: -65.15%
• 1Y: -71.94%
• 3Y*: -38.58%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

AYTU vs. CVKD — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AYTU

AYTU Risk / Return Rank: 85
AYTU Sharpe Ratio Rank: 75
AYTU Sortino Ratio Rank: 91
AYTU Omega Ratio Rank: 89
AYTU Calmar Ratio Rank: 84
AYTU Martin Ratio Rank: 84

CVKD

CVKD Risk / Return Rank: 7
CVKD Sharpe Ratio Rank: 9
CVKD Sortino Ratio Rank: 8
CVKD Omega Ratio Rank: 9
CVKD Calmar Ratio Rank: 4
CVKD Martin Ratio Rank: 3

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AYTU vs. CVKD - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Aytu BioPharma, Inc. (AYTU) and Cadrenal Therapeutics Inc. Common Stock (CVKD). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AYTU	CVKD	Difference
Sharpe ratio Return per unit of total volatility	1.09	-0.75	+1.84
Sortino ratio Return per unit of downside risk	3.01	-1.23	+4.24
Omega ratio Gain probability vs. loss probability	1.39	0.86	+0.53
Calmar ratio Return relative to maximum drawdown	2.83	-0.95	+3.78
Martin ratio Return relative to average drawdown	7.53	-1.80	+9.33
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AYTU vs. CVKD - Sharpe Ratio Comparison

The current AYTU Sharpe Ratio is 1.09, which is higher than the CVKD Sharpe Ratio of -0.75. The chart below compares the historical Sharpe Ratios of AYTU and CVKD, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	AYTU	CVKD	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.09	-0.75	+1.84
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.65	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.36	-0.54	+0.18

Correlation

The correlation between AYTU and CVKD is 0.11, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

AYTU vs. CVKD - Dividend Comparison

Neither AYTU nor CVKD has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

AYTU vs. CVKD - Drawdown Comparison

The maximum AYTU drawdown since its inception was -100.00%, which is greater than CVKD's maximum drawdown of -93.12%. Use the drawdown chart below to compare losses from any high point for AYTU and CVKD.

Drawdown Indicators

	AYTU	CVKD	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-93.12%	-6.88%
Max Drawdown (1Y) Largest decline over 1 year	-42.47%	-75.95%	+33.48%
Max Drawdown (5Y) Largest decline over 5 years	-99.34%	—	—
Current Drawdown Current decline from peak	-100.00%	-92.07%	-7.93%
Average Drawdown Average peak-to-trough decline	-95.05%	-78.10%	-16.95%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.93%	40.15%	-24.22%

Volatility

AYTU vs. CVKD - Volatility Comparison

The current volatility for Aytu BioPharma, Inc. (AYTU) is 10.33%, while Cadrenal Therapeutics Inc. Common Stock (CVKD) has a volatility of 30.00%. This indicates that AYTU experiences smaller price fluctuations and is considered to be less risky than CVKD based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AYTU	CVKD	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.33%	30.00%	-19.67%
Volatility (6M) Calculated over the trailing 6-month period	38.47%	78.39%	-39.92%
Volatility (1Y) Calculated over the trailing 1-year period	117.92%	95.63%	+22.29%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	85.84%	101.74%	-15.90%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	190.00%	101.74%	+88.26%

Financials