AMZA vs. BBC

Last updated Jun 25, 2026

AMZA (InfraCap MLP ETF) and BBC (Virtus LifeSci Biotech Clinical Trials ETF) are both exchange-traded funds - AMZA is a MLPs fund actively managed by Virtus Investment Partners, while BBC is a Health & Biotech Equities fund tracking the LifeSci Biotechnology Clinical Trials Index. AMZA is actively managed, while BBC is passively managed. Over the past 10 years, AMZA returned 4.65%/yr vs 11.30%/yr for BBC. At a 0.27 correlation, their price movements are largely independent. AMZA charges 2.01%/yr vs 0.79%/yr for BBC.

Performance

AMZA vs. BBC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in InfraCap MLP ETF (AMZA) and Virtus LifeSci Biotech Clinical Trials ETF (BBC). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AMZA achieves a 18.51% return, which is significantly lower than BBC's 27.49% return. Over the past 10 years, AMZA has underperformed BBC with an annualized return of 4.65%, while BBC has yielded a comparatively higher 11.30% annualized return.

AMZA

• 1D: -3.41%
• 1M: -6.40%
• YTD: 18.51%
• 6M: 18.21%
• 1Y: 14.09%
• 3Y*: 21.29%
• 5Y*: 18.59%
• 10Y*: 4.65%

BBC

• 1D: 1.38%
• 1M: 15.11%
• YTD: 27.49%
• 6M: 21.92%
• 1Y: 152.00%
• 3Y*: 27.59%
• 5Y*: -0.18%
• 10Y*: 11.30%

*Multi-year figures are annualized to reflect compound growth (CAGR)

AMZA vs. BBC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
AMZA InfraCap MLP ETF	18.51%	0.17%	30.90%	23.35%	33.20%	51.22%	-49.25%	6.27%	-26.78%	-6.90%
BBC Virtus LifeSci Biotech Clinical Trials ETF	27.49%	63.77%	-1.11%	-1.80%	-35.13%	-22.31%	30.32%	63.81%	-18.29%	57.85%

Correlation

The correlation between AMZA and BBC is -0.04, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.04
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (5Y) Calculated over the trailing 5-year period	0.22
Correlation (10Y) Calculated over the trailing 10-year period	0.28
Correlation (All Time) Calculated using the full available price history since Dec 17, 2014	0.27

The correlation between AMZA and BBC shifts across timeframes, from -0.04 (1 year) to 0.28 (10 years), reflecting how their relationship changes across market environments.

AMZA vs. BBC - Sectors Allocation Comparison

Sectors	AMZA	BBC
Energy	99.8%	-
Utilities	0.2%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Financial Services	-	-
Healthcare	-	100.0%
Industrials	-	-
Real Estate	-	-
Technology	-	-

Return for Risk

AMZA vs. BBC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AMZA

AMZA Risk / Return Rank: 24
AMZA Sharpe Ratio Rank: 24
AMZA Sortino Ratio Rank: 23
AMZA Omega Ratio Rank: 22
AMZA Calmar Ratio Rank: 26
AMZA Martin Ratio Rank: 24

BBC

BBC Risk / Return Rank: 95
BBC Sharpe Ratio Rank: 97
BBC Sortino Ratio Rank: 95
BBC Omega Ratio Rank: 92
BBC Calmar Ratio Rank: 97
BBC Martin Ratio Rank: 96

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AMZA vs. BBC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for InfraCap MLP ETF (AMZA) and Virtus LifeSci Biotech Clinical Trials ETF (BBC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	AMZA	BBC	Difference
Sharpe ratio: Return per unit of total volatility	0.78	4.23	-3.45
Sortino ratio: Return per unit of downside risk	1.19	4.61	-3.42
Omega ratio: Gain probability vs. loss probability	1.14	1.55	-0.41
Calmar ratio: Return relative to maximum drawdown	1.16	10.13	-8.96
Martin ratio: Return relative to average drawdown	2.84	29.69	-26.85

AMZA vs. BBC - Sharpe Ratio Comparison

The current AMZA Sharpe Ratio is 0.78, which is lower than the BBC Sharpe Ratio of 4.23. The chart below compares the historical Sharpe Ratios of AMZA and BBC, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

AMZA vs. BBC - Drawdown Comparison

The maximum AMZA drawdown since its inception was -91.46%, which is greater than BBC's maximum drawdown of -76.85%. Use the drawdown chart below to compare losses from any high point for AMZA and BBC.

Drawdown Indicators

	AMZA	BBC	Difference
Max Drawdown Largest peak-to-trough decline	-91.46%	-76.85%	-14.61%
Max Drawdown (1Y) Largest decline over 1 year	-12.16%	-15.10%	+2.94%
Max Drawdown (3Y) Largest decline over 3 years	-18.56%	-54.45%	+35.89%
Max Drawdown (5Y) Largest decline over 5 years	-25.15%	-71.97%	+46.82%
Max Drawdown (10Y) Largest decline over 10 years	-86.84%	-76.85%	-9.99%
Current Drawdown Current decline from peak	-12.92%	-18.17%	+5.25%
Average Drawdown Average peak-to-trough decline	-44.84%	-37.07%	-7.77%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.97%	5.14%	-0.17%

Volatility

AMZA vs. BBC - Volatility Comparison

The current volatility for InfraCap MLP ETF (AMZA) is 6.68%, while Virtus LifeSci Biotech Clinical Trials ETF (BBC) has a volatility of 11.92%. This indicates that AMZA experiences smaller price fluctuations and is considered to be less risky than BBC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AMZA	BBC	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.68%	11.92%	-5.24%
Volatility (6M) Calculated over the trailing 6-month period	14.02%	26.73%	-12.71%
Volatility (1Y) Calculated over the trailing 1-year period	18.15%	36.27%	-18.12%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.71%	39.51%	-13.80%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	37.21%	37.75%	-0.54%

AMZA vs. BBC - Expense Ratio Comparison

AMZA has a 2.01% expense ratio, which is higher than BBC's 0.79% expense ratio.

Dividends

AMZA vs. BBC - Dividend Comparison

AMZA's dividend yield for the trailing twelve months is around 8.45%, more than BBC's 1.33% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AMZA InfraCap MLP ETF	8.45%	8.81%	7.29%	9.40%	7.65%	10.24%	22.13%	19.47%	34.46%	24.16%	18.36%	18.21%
BBC Virtus LifeSci Biotech Clinical Trials ETF	1.33%	1.70%	1.00%	0.34%	0.00%	0.00%	0.00%	0.00%	0.00%	2.09%	0.00%	0.51%

Frequently Asked Questions

Can I hold both AMZA and BBC in my portfolio?

AMZA and BBC have a correlation of -0.04, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AMZA or BBC?

BBC has higher volatility (11.92%) compared to AMZA (6.68%). In terms of maximum drawdown, AMZA dropped -91.46% vs BBC's -76.85%.

Which ETF is better, AMZA or BBC?

On 10-year performance, BBC leads with 11.30% vs 4.65% for AMZA. On fees, BBC is cheaper at 0.79% per year. On volatility, AMZA has been the lower-risk option at 6.68%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, AMZA or BBC?

Over the 10-year period, BBC has performed better with a 11.30% return vs 4.65%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, AMZA or BBC?

BBC is cheaper with a 0.79% expense ratio, compared with 2.01% for AMZA.

Which ETF pays a higher dividend yield, AMZA or BBC?

AMZA has the higher dividend yield at 8.45%, compared with 1.33% for BBC.

What is the main difference between AMZA and BBC?

AMZA is categorized as MLPs, while BBC is Health & Biotech Equities. Their fees differ too: 2.01% for AMZA and 0.79% for BBC.

Which has better risk-adjusted returns?

BBC currently has the higher Sharpe Ratio (4.23 vs 0.78), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.