F/m Emerald Life Sciences Innovation ETF (LFSC) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with LFSC. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to LFSC
LFSC charges 0.54% annually. There are 32 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | LFSC vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | LFSC vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | LFSC vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | LFSC vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | LFSC vs GSKH |
Best Risk-Adjusted Alternatives to LFSC
LFSC has a PortfoliosLab risk / return rank of 92. There are 6 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | LFSC vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | LFSC vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | LFSC vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | LFSC vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | LFSC vs IBRN |
Top Performing LFSC Alternatives (YTD)
LFSC is at 26.42% YTD. There are 7 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | LFSC vs ARKG | |
| AdvisorShares Psychedelics ETF | 38.09% | 44.37M | Sep 2021 | LFSC vs PSIL | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | LFSC vs BBC | |
| Roundhill UNH WeeklyPay ETF | 32.77% | 6.01M | Dec 2025 | LFSC vs UNHW | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | LFSC vs SBIO |
Lowest Volatility Alternatives to LFSC
LFSC has 26.59% 1-year volatility. There are 57 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | LFSC vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | LFSC vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.63% | 10.11M | Jun 2007 | LFSC vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.89% | 16.78M | Jul 2025 | LFSC vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.77% | 982.35K | Apr 2026 | LFSC vs MHIP |
Lowest Drawdown Alternatives to LFSC
LFSC has a 1-year max drawdown of -16.25%. There are 40 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | LFSC vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | LFSC vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | LFSC vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | LFSC vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | LFSC vs IHE |
Other ETFs from F/m Investments
The 8 most viewed F/m Investments ETFs shown here include TBIL, ZHOG, UTWY and span 9 categories. AUM among these funds goes as high as $7B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| F/m US Treasury 3 Month Bill ETF | Ultrashort Bond | 100 | 1.91% | 7.15B | Aug 2022 | LFSC vs TBIL | |
| F/m Opportunistic Income ETF | Intermediate Core-Plus Bond | 91 | 1.19% | 46.19M | Sep 2023 | LFSC vs ZHOG | |
| F/m US Treasury 20 Year Bond ETF | Government Bonds, Long-Term Bond | 13 | -1.11% | 8.40M | Mar 2023 | LFSC vs UTWY | |
| F/m Emerald Special Situations ETF | Large Cap Growth Equities | — | 29.78% | 29.00M | Aug 2014 | LFSC vs SPIT | |
| F/m Ultrashort Tax-Free Municipal ETF | Municipal Bonds | — | 1.88% | 33.31M | Sep 2025 | LFSC vs ZMUN | |
| F/m High Yield 100 ETF | High Yield Bonds | 66 | 1.90% | 16.02M | Apr 2025 | LFSC vs ZTOP | |
| F/m Compoundr U.S. Aggregate Bond ETF | Total Bond Market, Intermediate Core Bond | — | -0.19% | 144.85M | Aug 2025 | LFSC vs CPAG | |
| F/m Compoundr High Yield Bond ETF | High Yield Bonds | — | 0.72% | 3.10M | Aug 2025 | LFSC vs CPHY |
Often Compared With LFSC
Investors most often compare LFSC with BMED, SURI, GDOC. These 20 comparison targets span 2 categories, based on PortfoliosLab usage data.
Compare LFSC with Any Fund or Stock
Compare LFSC with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair LFSC with funds that move differently
F/m Emerald Life Sciences Innovation ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to LFSC.
Explore LFSC Diversifiers