F/m Emerald Life Sciences Innovation ETF (LFSC) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with LFSC. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to LFSC
LFSC charges 0.54% annually. There are 33 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | LFSC vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | LFSC vs XLV | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | LFSC vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | LFSC vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | LFSC vs PBPH |
Best Risk-Adjusted Alternatives to LFSC
LFSC has a PortfoliosLab risk / return rank of 94. There are 6 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| iShares U.S. Pharmaceuticals ETF | 96 | 1.65B | May 2006 | LFSC vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 96 | 911.09M | Sep 2016 | LFSC vs FTXH | |
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | LFSC vs BBC | |
| Invesco Dynamic Pharmaceuticals ETF | 95 | 472.10M | Jun 2005 | LFSC vs PJP | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | LFSC vs SBIO |
Top Performing LFSC Alternatives (YTD)
LFSC is at 24.40% YTD. There are 4 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.87%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 36.87% | 48.53M | Sep 2021 | LFSC vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 33.10% | 1.73B | Oct 2014 | LFSC vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 28.78% | 7.27M | Dec 2025 | LFSC vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 26.39% | 47.80M | Dec 2014 | LFSC vs BBC | |
| SPDR S&P Health Care Services ETF | 24.28% | 206.72M | Sep 2011 | LFSC vs XHS |
Lowest Volatility Alternatives to LFSC
LFSC has 27.28% 1-year volatility. There are 58 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | LFSC vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | LFSC vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.09M | Jun 2007 | LFSC vs SPAQ | |
| Milliman Healthcare Inflation Plus ETF | 10.97% | 982.35K | Apr 2026 | LFSC vs MHIP | |
| State Street Health Care Select Sector SPDR Premiu... | 11.07% | 21.55M | Jul 2025 | LFSC vs XLVI |
Lowest Drawdown Alternatives to LFSC
LFSC has a 1-year max drawdown of -16.25%. There are 42 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | LFSC vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | LFSC vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | LFSC vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | LFSC vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | LFSC vs IBBQ |
Other ETFs from F/m
The 10 most viewed F/m ETFs shown here include TBIL, RBIL, ZTWO and span 10 categories. AUM among these funds goes as high as $7B.
Often Compared With LFSC
Investors most often compare LFSC with BMED, SURI, XBI. These 20 comparison targets span 4 categories, based on PortfoliosLab usage data.
Compare LFSC with Any Fund or Stock
Compare LFSC with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair LFSC with funds that move differently
F/m Emerald Life Sciences Innovation ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to LFSC.
Explore LFSC Diversifiers