iShares U.S. Healthcare ETF (IYH) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with IYH. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to IYH
IYH charges 0.43% annually. There are 20 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | IYH vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | IYH vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | IYH vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | IYH vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | IYH vs PBPH |
Best Risk-Adjusted Alternatives to IYH
IYH has a PortfoliosLab risk / return rank of 65. There are 34 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | IYH vs BBC | |
| iShares U.S. Pharmaceuticals ETF | 95 | 1.65B | May 2006 | IYH vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 95 | 911.09M | Sep 2016 | IYH vs FTXH | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | IYH vs SBIO | |
| Invesco Dynamic Pharmaceuticals ETF | 94 | 472.10M | Jun 2005 | IYH vs PJP |
Top Performing IYH Alternatives (YTD)
IYH is at 5.42% YTD. There are 43 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.76%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 36.76% | 1.73B | Oct 2014 | IYH vs ARKG | |
| AdvisorShares Psychedelics ETF | 36.69% | 48.53M | Sep 2021 | IYH vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 28.89% | 7.27M | Dec 2025 | IYH vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 27.03% | 47.80M | Dec 2014 | IYH vs BBC | |
| SPDR S&P Health Care Services ETF | 25.67% | 206.72M | Sep 2011 | IYH vs XHS |
Lowest Volatility Alternatives to IYH
IYH has 15.64% 1-year volatility. There are 10 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | IYH vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IYH vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.66% | 10.09M | Jun 2007 | IYH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.75% | 21.55M | Jul 2025 | IYH vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 10.92% | 982.35K | Apr 2026 | IYH vs MHIP |
Lowest Drawdown Alternatives to IYH
IYH has a 1-year max drawdown of -10.64%. There are 18 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IYH vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | IYH vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | IYH vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | IYH vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | IYH vs IBBQ |
Other ETFs from iShares
The 10 most viewed iShares ETFs shown here include SGOV, IBIT, SOXX and span 14 categories. AUM among these funds goes as high as $869B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| iShares 0-3 Month Treasury Bond ETF | Ultrashort Bond | 100 | 2.13% | 99.95B | May 2020 | IYH vs SGOV | |
| iShares Bitcoin Trust ETF | Cryptocurrency | 2 | -27.17% | 46.52B | Jan 2024 | IYH vs IBIT | |
| iShares Semiconductor ETF | Semiconductors, Technology Equities | 90 | 68.76% | 44.69B | Jul 2001 | IYH vs SOXX | |
| iShares Core S&P 500 ETF | S&P 500 | 78 | 11.75% | 869.20B | May 2000 | IYH vs IVV | |
| iShares Core Dividend Growth ETF | Large Cap Growth Equities, Dividend | 92 | 13.79% | 42.77B | Jun 2014 | IYH vs DGRO | |
| iShares 20+ Year Treasury Bond ETF | Government Bonds, Long-Term Bond | 7 | -3.18% | 41.54B | Jul 2002 | IYH vs TLT | |
| iShares Silver Trust | Silver, Precious Metals | 35 | -18.57% | 28.08B | Apr 2006 | IYH vs SLV | |
| iShares Gold Trust | Gold, Precious Metals | 28 | -6.14% | 59.74B | Jan 2005 | IYH vs IAU | |
| iShares Russell 2000 ETF | Small Cap Blend Equities | 85 | 20.84% | 80.11B | May 2000 | IYH vs IWM | |
| iShares MSCI ACWI ETF | Global Equities | 77 | 12.35% | 32.49B | Mar 2008 | IYH vs ACWI |
Often Compared With IYH
Investors most often compare IYH with SPY, IYE, BMED. These 20 comparison targets span 13 categories, based on PortfoliosLab usage data.
Compare IYH with Any Fund or Stock
Compare IYH with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair IYH with funds that move differently
iShares U.S. Healthcare ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to IYH.
Explore IYH Diversifiers