Franklin Genomic Advancements ETF (HELX) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with HELX. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to HELX
HELX charges 0.50% annually. There are 25 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | HELX vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | HELX vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | HELX vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | HELX vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | HELX vs GSKH |
Best Risk-Adjusted Alternatives to HELX
HELX has a PortfoliosLab risk / return rank of 64. There are 23 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | HELX vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | HELX vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | HELX vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 93 | 1.34B | May 2006 | HELX vs IHE | |
| iShares Neuroscience and Healthcare ETF | 92 | 5.85M | Aug 2022 | HELX vs IBRN |
Top Performing HELX Alternatives (YTD)
HELX is at 8.78% YTD. There are 27 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 41.70%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 41.70% | 1.31B | Oct 2014 | HELX vs ARKG | |
| AdvisorShares Psychedelics ETF | 38.20% | 44.37M | Sep 2021 | HELX vs PSIL | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.75% | 57.56M | Dec 2014 | HELX vs BBC | |
| Roundhill UNH WeeklyPay ETF | 32.80% | 6.01M | Dec 2025 | HELX vs UNHW | |
| SPDR S&P Biotech ETF | 27.62% | 11.10B | Feb 2006 | HELX vs XBI |
Lowest Volatility Alternatives to HELX
HELX has 21.89% 1-year volatility. There are 42 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | HELX vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HELX vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.63% | 10.11M | Jun 2007 | HELX vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.96% | 16.78M | Jul 2025 | HELX vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.68% | 982.35K | Apr 2026 | HELX vs MHIP |
Lowest Drawdown Alternatives to HELX
HELX has a 1-year max drawdown of -18.01%. There are 43 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HELX vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | HELX vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | HELX vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | HELX vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | HELX vs IHE |
Other ETFs from Franklin Templeton
The 10 most viewed Franklin Templeton ETFs shown here include LVHI, FLIN, FLKR and span 11 categories. AUM among these funds goes as high as $5B.
Often Compared With HELX
Investors most often compare HELX with IDNA, BBH, BMEZ. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare HELX with Any Fund or Stock
Compare HELX with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair HELX with funds that move differently
Franklin Genomic Advancements ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to HELX.
Explore HELX Diversifiers