Franklin Genomic Advancements ETF (HELX) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with HELX. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to HELX
HELX charges 0.50% annually. There are 24 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.99B | Oct 2013 | HELX vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.47B | Dec 1998 | HELX vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | HELX vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | HELX vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | HELX vs GSKH |
Best Risk-Adjusted Alternatives to HELX
HELX has a PortfoliosLab risk / return rank of 45. There are 24 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 95.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 95 | 40.93M | Dec 2014 | HELX vs BBC | |
| ALPS Medical Breakthroughs ETF | 92 | 160.12M | Dec 2014 | HELX vs SBIO | |
| SPDR S&P Biotech ETF | 90 | 8.62B | Feb 2006 | HELX vs XBI | |
| iShares Neuroscience and Healthcare ETF | 89 | 5.39M | Aug 2022 | HELX vs IBRN | |
| First Trust Nasdaq Pharmaceuticals ETF | 87 | 33.60M | Sep 2016 | HELX vs FTXH |
Top Performing HELX Alternatives (YTD)
HELX is at 0.89% YTD. There are 34 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 27.05%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| Roundhill UNH WeeklyPay ETF | 27.05% | 4.79M | Dec 2025 | HELX vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 25.75% | 40.93M | Dec 2014 | HELX vs BBC | |
| AdvisorShares Psychedelics ETF | 25.04% | 33.07M | Sep 2021 | HELX vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 24.30% | 1.31B | Oct 2014 | HELX vs ARKG | |
| SPDR S&P Biotech ETF | 20.70% | 8.62B | Feb 2006 | HELX vs XBI |
Lowest Volatility Alternatives to HELX
HELX has 21.37% 1-year volatility. There are 36 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | HELX vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HELX vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.10M | Jun 2007 | HELX vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 14.95M | Jul 2025 | HELX vs XLVI | |
| Global X Aging Population ETF | 13.70% | 80.19M | May 2016 | HELX vs AGNG |
Lowest Drawdown Alternatives to HELX
HELX has a 1-year max drawdown of -18.01%. There are 42 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | HELX vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.00% | 10.10M | Jun 2007 | HELX vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 33.60M | Sep 2016 | HELX vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 68.94M | Jun 2021 | HELX vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 956.44M | May 2006 | HELX vs IHE |
Other ETFs from Franklin Templeton
The 10 most viewed Franklin Templeton ETFs shown here include LVHI, FLIN, FLKR and span 9 categories. AUM among these funds goes as high as $5B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Franklin International Low Volatility High Dividen... | Volatility Hedged Equity, Dividend | 93 | 12.42% | 4.99B | Jul 2016 | HELX vs LVHI | |
| Franklin FTSE India ETF | Asia Pacific Equities | 4 | -8.37% | 2.55B | Feb 2018 | HELX vs FLIN | |
| Franklin FTSE South Korea ETF | Asia Pacific Equities | 92 | 97.22% | 1.16B | Nov 2017 | HELX vs FLKR | |
| Franklin U.S. Low Volatility High Dividend Index E... | Dividend | 40 | 10.55% | 588.56M | Dec 2015 | HELX vs LVHD | |
| Franklin International Core Dividend Tilt Index ET... | Foreign Large Cap Equities, Dividend | 54 | 10.71% | 2.60B | Jun 2016 | HELX vs DIVI | |
| Putnam BDC Income ETF | Financials Equities | 4 | -11.42% | 272.46M | Sep 2022 | HELX vs PBDC | |
| Franklin FTSE Japan ETF | Japan Equities | 53 | 15.09% | 3.93B | Nov 2017 | HELX vs FLJP | |
| Franklin Responsibly Sourced Gold ETF | Gold, Precious Metals | 21 | -4.86% | 437.03M | Jun 2022 | HELX vs FGDL | |
| Franklin FTSE China ETF | China Equities | 9 | -12.17% | 264.76M | Nov 2017 | HELX vs FLCH | |
| Franklin FTSE Japan Hedged ETF | Japan Equities | 82 | 20.28% | 171.61M | Nov 2017 | HELX vs FLJH |
Often Compared With HELX
Investors most often compare HELX with IDNA, BBH, BMEZ. These 20 comparison targets span 7 categories, based on PortfoliosLab usage data.
Compare HELX with Any Fund or Stock
Compare HELX with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair HELX with funds that move differently
Franklin Genomic Advancements ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to HELX.
Explore HELX Diversifiers