The Best Health & Biotech Equities ETFs
The table below compares the performance and other essential indicators like dividend yield and expense ratio of Health & Biotech Equities ETFs.
Health & Biotech Equities ETFs are exchange-traded funds that invest in a diversified portfolio of companies that operate in the healthcare and biotechnology sectors. These sectors include companies involved in the research, development, and production of medical products, drugs, and therapies. They can also include companies that provide healthcare services, such as hospitals, insurance companies, and medical device manufacturers.
Health & biotech ETFs can provide investors with exposure to the growth potential of these sectors, which are driven by factors such as demographic changes, technological advancements, and growing demand for healthcare services. However, it's important to note that these ETFs can be more volatile and risky than the overall market, as the success of many companies in this sector is heavily dependent on clinical trial results and regulatory approvals.
- Number of ETFs
- 68
- Avg. Expense Ratio
- 0.59%
- Avg. Dividend Yield
- 3.01%
- Avg. 1 Year Return
- 37.10%
- Median Risk/Return Score
- 58 / 100
3 results
| Symbol | Full Name | Category | Inception | Expense Ratio | YTD Return | 10Y Return (Annualized) | Dividend Yield | Risk / Return Rank | Max. Drawdown | Sharpe Ratio | Sortino Ratio | Omega Ratio | Martin Ratio | Calmar Ratio | Ulcer Index |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Global X S&P Biotech ETF | Health & Biotech Equities | Nov 8, 2018 | 0.45% | 22.66% | — | 0.00% | 90 | ||||||||
| Betashares Global Healthcare Currency Hedged ETF | Health & Biotech Equities | Aug 4, 2016 | 0.57% | -0.40% | — | 3.69% | 34 | ||||||||
| iShares Global Healthcare ETF (AU) | Health & Biotech Equities | Mar 11, 2009 | — | -3.55% | 9.55% | 1.11% | 18 |
Best Health & Biotech Equities ETFs by Risk/Return Score
| Symbol | Name | Risk / Return Rank | AUM | Inception |
|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | |
| SPDR S&P Biotech ETF | 95 | 11.10B | Feb 2006 | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | |
| First Trust Nasdaq Pharmaceuticals ETF | 93 | 36.36M | Sep 2016 |
Best-Performing Health & Biotech Equities ETFs Over 5 Years
| Symbol | Name | Return 5Y | AUM | Inception |
|---|---|---|---|---|
| Virtus LifeSci Biotech Products ETF | 14.05% | 98.34M | Dec 2014 | |
| iShares U.S. Pharmaceuticals ETF | 11.74% | 1.34B | May 2006 | |
| VanEck Pharmaceutical ETF | 10.27% | 944.89M | Dec 2011 | |
| First Trust Nasdaq Pharmaceuticals ETF | 9.61% | 36.36M | Sep 2016 | |
| Invesco Dynamic Pharmaceuticals ETF | 9.37% | 357.90M | Jun 2005 |
Lowest-Cost Health & Biotech Equities ETFs
| Symbol | Name | Expense Ratio | AUM | Inception |
|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | |
| Invesco Nasdaq Biotechnology ETF | 0.19% | 74.65M | Jun 2021 |
Highest-Yield Health & Biotech Equities ETFs
| Symbol | Name | Dividend Yield | AUM | Inception |
|---|---|---|---|---|
| YieldMax HIMS Option Income Strategy ETF | 87.29% | 11.00M | Sep 2025 | |
| Roundhill UNH WeeklyPay ETF | 20.12% | 6.01M | Dec 2025 | |
| Horizon Kinetics SPAC Active ETF | 16.10% | 10.11M | Jun 2007 | |
| Simplify Propel Opportunities ETF | 15.11% | 77.42M | Feb 2023 | |
| State Street Health Care Select Sector SPDR Premiu... | 12.10% | 16.78M | Jul 2025 |
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