WVE vs. IONS
Compare and contrast key facts about Wave Life Sciences Ltd. (WVE) and Ionis Pharmaceuticals, Inc. (IONS).
Performance
WVE vs. IONS - Performance Comparison
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WVE vs. IONS - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
WVE Wave Life Sciences Ltd. | -57.35% | 37.43% | 144.95% | -27.86% | 122.93% | -60.10% | -1.81% | -80.93% | 19.77% | 34.23% |
IONS Ionis Pharmaceuticals, Inc. | -5.08% | 126.29% | -30.90% | 33.94% | 24.12% | -46.18% | -6.41% | 11.75% | 7.48% | 5.16% |
Fundamentals
WVE:
$1.31B
IONS:
$12.16B
WVE:
-$1.20
IONS:
-$2.26
WVE:
28.95
IONS:
13.40
WVE:
2.52
IONS:
24.88
WVE:
$42.73M
IONS:
$943.38M
WVE:
$21.12M
IONS:
$927.39M
WVE:
-$206.29M
IONS:
-$288.11M
Returns By Period
In the year-to-date period, WVE achieves a -57.35% return, which is significantly lower than IONS's -5.08% return. Over the past 10 years, WVE has underperformed IONS with an annualized return of -6.17%, while IONS has yielded a comparatively higher 6.23% annualized return.
WVE
- 1D
- 9.52%
- 1M
- -47.95%
- YTD
- -57.35%
- 6M
- -0.96%
- 1Y
- -10.27%
- 3Y*
- 18.75%
- 5Y*
- 3.55%
- 10Y*
- -6.17%
IONS
- 1D
- 3.54%
- 1M
- -7.47%
- YTD
- -5.08%
- 6M
- 14.78%
- 1Y
- 148.89%
- 3Y*
- 28.08%
- 5Y*
- 10.76%
- 10Y*
- 6.23%
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Return for Risk
WVE vs. IONS — Risk / Return Rank
WVE
IONS
WVE vs. IONS - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Wave Life Sciences Ltd. (WVE) and Ionis Pharmaceuticals, Inc. (IONS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| WVE | IONS | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | -0.06 | 2.96 | -3.02 |
Sortino ratioReturn per unit of downside risk | 1.26 | 4.28 | -3.02 |
Omega ratioGain probability vs. loss probability | 1.20 | 1.57 | -0.37 |
Calmar ratioReturn relative to maximum drawdown | -0.22 | 7.25 | -7.48 |
Martin ratioReturn relative to average drawdown | -0.60 | 25.04 | -25.64 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| WVE | IONS | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.06 | 2.96 | -3.02 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.03 | 0.25 | -0.22 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.06 | 0.13 | -0.19 |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.07 | 0.10 | -0.18 |
Correlation
The correlation between WVE and IONS is 0.26, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
WVE vs. IONS - Dividend Comparison
Neither WVE nor IONS has paid dividends to shareholders.
Drawdowns
WVE vs. IONS - Drawdown Comparison
The maximum WVE drawdown since its inception was -97.77%, which is greater than IONS's maximum drawdown of -91.42%. Use the drawdown chart below to compare losses from any high point for WVE and IONS.
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Drawdown Indicators
| WVE | IONS | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.77% | -91.42% | -6.35% |
Max Drawdown (1Y)Largest decline over 1 year | -70.91% | -19.45% | -51.46% |
Max Drawdown (5Y)Largest decline over 5 years | -83.53% | -52.36% | -31.17% |
Max Drawdown (10Y)Largest decline over 10 years | -97.77% | -70.39% | -27.38% |
Current DrawdownCurrent decline from peak | -86.87% | -13.19% | -73.68% |
Average DrawdownAverage peak-to-trough decline | -64.37% | -52.59% | -11.78% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 26.68% | 5.63% | +21.05% |
Volatility
WVE vs. IONS - Volatility Comparison
Wave Life Sciences Ltd. (WVE) has a higher volatility of 70.76% compared to Ionis Pharmaceuticals, Inc. (IONS) at 10.99%. This indicates that WVE's price experiences larger fluctuations and is considered to be riskier than IONS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| WVE | IONS | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 70.76% | 10.99% | +59.77% |
Volatility (6M)Calculated over the trailing 6-month period | 124.74% | 22.34% | +102.40% |
Volatility (1Y)Calculated over the trailing 1-year period | 171.05% | 50.77% | +120.28% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 114.66% | 42.73% | +71.93% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 98.93% | 48.55% | +50.38% |
Financials
WVE vs. IONS - Financials Comparison
This section allows you to compare key financial metrics between Wave Life Sciences Ltd. and Ionis Pharmaceuticals, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities