WDNA vs. SBIO

Last updated Jun 5, 2026

WDNA (WisdomTree BioRevolution Fund) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - WDNA tracks the WisdomTree BioRevolution Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 5 years, WDNA returned -4.78%/yr vs 3.16%/yr for SBIO. Their correlation of 0.85 suggests significant overlap in exposure. WDNA charges 0.45%/yr vs 0.50%/yr for SBIO.

Performance

WDNA vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in WisdomTree BioRevolution Fund (WDNA) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, WDNA achieves a 8.96% return, which is significantly higher than SBIO's 1.95% return.

WDNA

• 1D: 2.94%
• 1M: 2.56%
• YTD: 8.96%
• 6M: 10.44%
• 1Y: 50.50%
• 3Y*: 3.54%
• 5Y*: -4.78%
• 10Y*: —

SBIO

• 1D: 2.35%
• 1M: -5.55%
• YTD: 1.95%
• 6M: 4.13%
• 1Y: 68.86%
• 3Y*: 18.38%
• 5Y*: 3.16%
• 10Y*: 8.03%

*Multi-year figures are annualized to reflect compound growth (CAGR)

WDNA vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
WDNA WisdomTree BioRevolution Fund	8.96%	22.68%	-14.18%	-2.07%	-26.29%	-5.27%
SBIO ALPS Medical Breakthroughs ETF	1.95%	55.07%	3.81%	8.68%	-28.08%	-8.21%

Correlation

The correlation between WDNA and SBIO is 0.78, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.78
Correlation (3Y) Calculated over the trailing 3-year period	0.82
Correlation (5Y) Calculated over the trailing 5-year period	0.85
Correlation (All Time) Calculated using the full available price history since Jun 4, 2021	0.85

The correlation between WDNA and SBIO has been stable across timeframes, ranging from 0.78 to 0.85 - a consistent structural relationship.

WDNA vs. SBIO - Sectors Allocation Comparison

Sectors	WDNA	SBIO
Healthcare	85.0%	100.0%
Basic Materials	6.5%	-
Consumer Defensive	3.0%	-
Energy	1.1%	-
Communication Services	-	-
Consumer Cyclical	-	-
Financial Services	-	-0.0%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

WDNA vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

WDNA

WDNA Risk / Return Rank: 63
WDNA Sharpe Ratio Rank: 59
WDNA Sortino Ratio Rank: 62
WDNA Omega Ratio Rank: 53
WDNA Calmar Ratio Rank: 83
WDNA Martin Ratio Rank: 57

SBIO

SBIO Risk / Return Rank: 76
SBIO Sharpe Ratio Rank: 74
SBIO Sortino Ratio Rank: 72
SBIO Omega Ratio Rank: 63
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 82

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

WDNA vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for WisdomTree BioRevolution Fund (WDNA) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	WDNA	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	1.98	2.35	-0.38
Sortino ratio: Return per unit of downside risk	2.85	3.22	-0.37
Omega ratio: Gain probability vs. loss probability	1.32	1.38	-0.05
Calmar ratio: Return relative to maximum drawdown	4.34	5.47	-1.13
Martin ratio: Return relative to average drawdown	9.85	16.23	-6.38
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

WDNA vs. SBIO - Sharpe Ratio Comparison

The current WDNA Sharpe Ratio is 1.98, which is comparable to the SBIO Sharpe Ratio of 2.35. The chart below compares the historical Sharpe Ratios of WDNA and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	WDNA	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.98	2.35	-0.38
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.19	0.09	-0.29
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.24	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.19	0.22	-0.41

Drawdowns

WDNA vs. SBIO - Drawdown Comparison

The maximum WDNA drawdown since its inception was -58.87%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for WDNA and SBIO.

Drawdown Indicators

	WDNA	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-58.87%	-63.06%	+4.19%
Max Drawdown (1Y) Largest decline over 1 year	-11.70%	-12.66%	+0.96%
Max Drawdown (3Y) Largest decline over 3 years	-38.25%	-42.44%	+4.19%
Max Drawdown (5Y) Largest decline over 5 years	-58.87%	-53.10%	-5.77%
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-29.86%	-14.84%	-15.02%
Average Drawdown Average peak-to-trough decline	-35.64%	-28.44%	-7.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.14%	4.26%	+0.88%

Volatility

WDNA vs. SBIO - Volatility Comparison

The current volatility for WisdomTree BioRevolution Fund (WDNA) is 7.35%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 9.85%. This indicates that WDNA experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	WDNA	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.35%	9.85%	-2.50%
Volatility (6M) Calculated over the trailing 6-month period	16.59%	22.76%	-6.17%
Volatility (1Y) Calculated over the trailing 1-year period	25.66%	29.40%	-3.74%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.08%	33.57%	-8.49%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.07%	33.18%	-8.11%

WDNA vs. SBIO - Expense Ratio Comparison

WDNA has a 0.45% expense ratio, which is lower than SBIO's 0.50% expense ratio.

Dividends

WDNA vs. SBIO - Dividend Comparison

WDNA's dividend yield for the trailing twelve months is around 4.19%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%
WDNA WisdomTree BioRevolution Fund	4.19%	4.57%	0.75%	0.80%	0.38%	0.10%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both WDNA and SBIO in my portfolio?

WDNA and SBIO have a correlation of 0.78, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, WDNA or SBIO?

SBIO has higher volatility (9.85%) compared to WDNA (7.35%). In terms of maximum drawdown, WDNA dropped -58.87% vs SBIO's -63.06%.

Which ETF is better, WDNA or SBIO?

On 5-year performance, SBIO leads with 3.16% vs -4.78% for WDNA. On fees, WDNA is cheaper at 0.45% per year. On volatility, WDNA has been the lower-risk option at 7.35%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, WDNA or SBIO?

Over the 5-year period, SBIO has performed better with a 3.16% return vs -4.78%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, WDNA or SBIO?

WDNA is cheaper with a 0.45% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, WDNA or SBIO?

WDNA has the higher dividend yield at 4.19%, compared with 0.00% for SBIO.

What is the main difference between WDNA and SBIO?

WDNA tracks WisdomTree BioRevolution Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: WisdomTree and SS&C. Their fees differ too: 0.45% for WDNA and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (2.35 vs 1.98), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.