VOO vs. REGN

Last updated Jun 9, 2026

VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index, while REGN (Regeneron Pharmaceuticals, Inc.) is a stock. Over the past 10 years, VOO returned 15.35%/yr vs 5.18%/yr for REGN. At a 0.40 correlation, their price movements are largely independent.

Performance

VOO vs. REGN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vanguard S&P 500 ETF (VOO) and Regeneron Pharmaceuticals, Inc. (REGN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VOO achieves a 8.72% return, which is significantly higher than REGN's -20.58% return. Over the past 10 years, VOO has outperformed REGN with an annualized return of 15.35%, while REGN has yielded a comparatively lower 5.18% annualized return.

VOO

• 1D: 0.25%
• 1M: 0.24%
• YTD: 8.72%
• 6M: 8.77%
• 1Y: 24.91%
• 3Y*: 21.45%
• 5Y*: 13.49%
• 10Y*: 15.35%

REGN

• 1D: -3.79%
• 1M: -14.36%
• YTD: -20.58%
• 6M: -12.84%
• 1Y: 24.63%
• 3Y*: -6.19%
• 5Y*: 3.39%
• 10Y*: 5.18%

*Multi-year figures are annualized to reflect compound growth (CAGR)

VOO vs. REGN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
VOO Vanguard S&P 500 ETF	8.72%	17.82%	24.98%	26.32%	-18.17%	28.79%	18.32%	31.37%	-4.50%	21.77%
REGN Regeneron Pharmaceuticals, Inc.	-20.58%	8.96%	-18.90%	21.73%	14.25%	30.72%	28.66%	0.53%	-0.65%	2.42%

Correlation

The correlation between VOO and REGN is 0.22, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.22
Correlation (3Y) Calculated over the trailing 3-year period	0.32
Correlation (5Y) Calculated over the trailing 5-year period	0.37
Correlation (10Y) Calculated over the trailing 10-year period	0.37
Correlation (All Time) Calculated using the full available price history since Sep 10, 2010	0.40

The correlation between VOO and REGN shifts across timeframes, from 0.22 (1 year) to 0.40 (all time), reflecting how their relationship changes across market environments.

Return for Risk

VOO vs. REGN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VOO

VOO Risk / Return Rank: 69
VOO Sharpe Ratio Rank: 71
VOO Sortino Ratio Rank: 68
VOO Omega Ratio Rank: 71
VOO Calmar Ratio Rank: 62
VOO Martin Ratio Rank: 75

REGN

REGN Risk / Return Rank: 64
REGN Sharpe Ratio Rank: 67
REGN Sortino Ratio Rank: 61
REGN Omega Ratio Rank: 60
REGN Calmar Ratio Rank: 62
REGN Martin Ratio Rank: 69

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

VOO vs. REGN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vanguard S&P 500 ETF (VOO) and Regeneron Pharmaceuticals, Inc. (REGN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	VOO	REGN	Difference
Sharpe ratio: Return per unit of total volatility	2.08	0.75	+1.33
Sortino ratio: Return per unit of downside risk	2.80	1.26	+1.54
Omega ratio: Gain probability vs. loss probability	1.38	1.16	+0.22
Calmar ratio: Return relative to maximum drawdown	2.81	0.96	+1.85
Martin ratio: Return relative to average drawdown	12.97	3.20	+9.78
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

VOO vs. REGN - Sharpe Ratio Comparison

The current VOO Sharpe Ratio is 2.08, which is higher than the REGN Sharpe Ratio of 0.75. The chart below compares the historical Sharpe Ratios of VOO and REGN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	VOO	REGN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.08	0.75	+1.33
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.80	0.11	+0.69
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.85	0.16	+0.69
Sharpe Ratio (All Time) Calculated using the full available price history	0.88	0.16	+0.72

Drawdowns

VOO vs. REGN - Drawdown Comparison

The maximum VOO drawdown since its inception was -33.99%, smaller than the maximum REGN drawdown of -91.81%. Use the drawdown chart below to compare losses from any high point for VOO and REGN.

Drawdown Indicators

	VOO	REGN	Difference
Max Drawdown Largest peak-to-trough decline	-33.99%	-91.81%	+57.82%
Max Drawdown (1Y) Largest decline over 1 year	-8.90%	-25.85%	+16.95%
Max Drawdown (3Y) Largest decline over 3 years	-18.69%	-59.69%	+41.00%
Max Drawdown (5Y) Largest decline over 5 years	-24.52%	-59.69%	+35.17%
Max Drawdown (10Y) Largest decline over 10 years	-33.99%	-59.69%	+25.70%
Current Drawdown Current decline from peak	-2.66%	-48.71%	+46.05%
Average Drawdown Average peak-to-trough decline	-3.69%	-42.39%	+38.70%
Ulcer Index Depth and duration of drawdowns from previous peaks	1.92%	7.73%	-5.81%

Volatility

VOO vs. REGN - Volatility Comparison

The current volatility for Vanguard S&P 500 ETF (VOO) is 3.73%, while Regeneron Pharmaceuticals, Inc. (REGN) has a volatility of 12.61%. This indicates that VOO experiences smaller price fluctuations and is considered to be less risky than REGN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VOO	REGN	Difference
Volatility (1M) Calculated over the trailing 1-month period	3.73%	12.61%	-8.88%
Volatility (6M) Calculated over the trailing 6-month period	9.31%	22.61%	-13.30%
Volatility (1Y) Calculated over the trailing 1-year period	12.08%	33.09%	-21.01%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.85%	30.82%	-13.97%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.03%	32.18%	-14.15%

Dividends

VOO vs. REGN - Dividend Comparison

VOO's dividend yield for the trailing twelve months is around 1.05%, more than REGN's 0.60% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
REGN Regeneron Pharmaceuticals, Inc.	0.60%	0.46%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.05%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both VOO and REGN in my portfolio?

VOO and REGN have a correlation of 0.22, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VOO or REGN?

REGN has higher volatility (12.61%) compared to VOO (3.73%). In terms of maximum drawdown, VOO dropped -33.99% vs REGN's -91.81%.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (2.08 vs 0.75), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.