REGN vs. VRTX
REGN (Regeneron Pharmaceuticals, Inc.) and VRTX (Vertex Pharmaceuticals Incorporated) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, REGN returned 5.54%/yr vs 17.24%/yr for VRTX. Their 0.35 correlation means their historical movements had little consistent relationship.
Performance
REGN vs. VRTX - Performance Comparison
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Returns By Period
In the year-to-date period, REGN achieves a -4.09% return, which is significantly lower than VRTX's 6.25% return. Over the past 10 years, REGN has underperformed VRTX with an annualized return of 5.54%, while VRTX has yielded a comparatively higher 17.24% annualized return.
REGN
- 1D
- 6.17%
- 1M
- 18.41%
- 6M
- -1.22%
- YTD
- -4.09%
- 1Y
- 33.86%
- 3Y*
- 0.11%
- 5Y*
- 5.32%
- 10Y*
- 5.54%
- ALL TIME*
- 10.48%
VRTX
- 1D
- -0.34%
- 1M
- -3.03%
- 6M
- 1.27%
- YTD
- 6.25%
- 1Y
- 2.67%
- 3Y*
- 10.99%
- 5Y*
- 19.03%
- 10Y*
- 17.24%
- ALL TIME*
- 14.23%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $582.80M | $536.07M | $650.72M | |
| $654.52M | $735.02M | $728.78M |
REGN vs. VRTX - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
REGN Regeneron Pharmaceuticals, Inc. | -4.09% | 8.96% | -18.90% | 21.73% | 14.25% | 30.72% | 28.66% | 0.53% | -0.65% | 2.42% |
VRTX Vertex Pharmaceuticals Incorporated | 6.25% | 12.58% | -1.03% | 40.90% | 31.50% | -7.08% | 7.94% | 32.13% | 10.58% | 103.42% |
Correlation
The correlation between REGN and VRTX is 0.41, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.41 |
Correlation (3Y) Balances recent behavior with more history. | 0.45 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.48 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.51 |
Correlation (All Time) Calculated using the full available price history since Jul 24, 1991 | 0.35 |
The correlation between REGN and VRTX shifts across timeframes, from 0.35 (all time) to 0.51 (10 years), reflecting how their relationship changes across market environments.
Fundamentals
REGN:
$76.07B
VRTX:
$122.26B
REGN:
$40.34
VRTX:
$16.90
REGN:
18.30
VRTX:
28.50
REGN:
5.10
VRTX:
10.09
REGN:
2.03
VRTX:
4.66
REGN:
$15.53B
VRTX:
$12.26B
REGN:
$13.69B
VRTX:
$10.57B
REGN:
$5.38B
VRTX:
$5.19B
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Return for Risk
REGN vs. VRTX — Risk / Return Rank
REGN
VRTX
REGN vs. VRTX - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Regeneron Pharmaceuticals, Inc. (REGN) and Vertex Pharmaceuticals Incorporated (VRTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| REGN | VRTX | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.93 | ||
| Sortino ratioReturn per unit of downside risk | +1.27 | ||
| Omega ratioGain probability vs. loss probability | 1.20 | 1.05 | +0.15 |
| Calmar ratioReturn relative to maximum drawdown | 1.32 | 0.12 | +1.20 |
| Martin ratioReturn relative to average drawdown | 3.12 | 0.24 | +2.87 |
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Drawdowns
REGN vs. VRTX - Drawdown Comparison
The maximum REGN drawdown since its inception was -91.81%, roughly equal to the maximum VRTX drawdown of -91.77%. Use the drawdown chart below to compare losses from any high point for REGN and VRTX.
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Drawdown Indicators
| REGN | VRTX | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.81% | -91.77% | -0.04% |
Max Drawdown (1Y)Largest decline over 1 year | -25.85% | -22.39% | -3.46% |
Max Drawdown (3Y)Largest decline over 3 years | -59.69% | -29.07% | -30.62% |
Max Drawdown (5Y)Largest decline over 5 years | -59.69% | -29.07% | -30.62% |
Max Drawdown (10Y)Largest decline over 10 years | -59.69% | -41.60% | -18.09% |
Current DrawdownCurrent decline from peak | -38.05% | -9.04% | -29.01% |
Average DrawdownAverage peak-to-trough decline | -42.46% | -37.62% | -4.84% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 10.90% | 10.96% | -0.06% |
Volatility
REGN vs. VRTX - Volatility Comparison
Regeneron Pharmaceuticals, Inc. (REGN) has a higher volatility of 10.56% compared to Vertex Pharmaceuticals Incorporated (VRTX) at 9.29%. This indicates that REGN's price experiences larger fluctuations and is considered to be riskier than VRTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| REGN | VRTX | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 10.56% | 9.29% | +1.27% |
Volatility (6M)Calculated over the trailing 6-month period | 23.18% | 21.33% | +1.85% |
Volatility (1Y)Calculated over the trailing 1-year period | 33.69% | 34.89% | -1.20% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 31.07% | 28.78% | +2.29% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 32.16% | 32.72% | -0.56% |
Dividends
REGN vs. VRTX - Dividend Comparison
REGN's dividend yield for the trailing twelve months is around 0.49%, while VRTX has not paid dividends to shareholders.
| Position | TTM | 2025 |
|---|---|---|
REGN Regeneron Pharmaceuticals, Inc. | 0.49% | 0.46% |
VRTX Vertex Pharmaceuticals Incorporated | 0.00% | 0.00% |
Financials
REGN vs. VRTX - Financials Comparison
This section allows you to compare key financial metrics between Regeneron Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
REGN vs. VRTX - Profitability Comparison
REGN - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jul 2026, Regeneron Pharmaceuticals, Inc. reported a gross profit of 4.22B and revenue of 4.29B. Therefore, the gross margin over that period was 98.3%.
VRTX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jul 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.59B and revenue of 2.99B. Therefore, the gross margin over that period was 86.9%.
REGN - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jul 2026, Regeneron Pharmaceuticals, Inc. reported an operating income of 1.29B and revenue of 4.29B, resulting in an operating margin of 30.2%.
VRTX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jul 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.14B and revenue of 2.99B, resulting in an operating margin of 38.1%.
REGN - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jul 2026, Regeneron Pharmaceuticals, Inc. reported a net income of 1.30B and revenue of 4.29B, resulting in a net margin of 30.2%.
VRTX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jul 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.03B and revenue of 2.99B, resulting in a net margin of 34.5%.
Frequently Asked Questions
REGN and VRTX have a correlation of 0.41, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
REGN has higher volatility (10.56%) compared to VRTX (9.29%). In terms of maximum drawdown, REGN dropped -91.81% vs VRTX's -91.77%.
REGN currently has the higher Sharpe Ratio (1.01 vs 0.08), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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