VOO vs. FMED

Last updated Jun 16, 2026

VOO (Vanguard S&P 500 ETF) and FMED (Fidelity Disruptive Medicine ETF) are both exchange-traded funds - VOO is a S&P 500 fund tracking the S&P 500 Index, while FMED is a Health & Biotech Equities fund actively managed by Fidelity. VOO is passively managed, while FMED is actively managed. Over the past 3 years, VOO returned 21.25%/yr vs 0.73%/yr for FMED. A 0.62 correlation means they provide meaningful diversification when combined. VOO charges 0.03%/yr vs 0.50%/yr for FMED.

Performance

VOO vs. FMED - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vanguard S&P 500 ETF (VOO) and Fidelity Disruptive Medicine ETF (FMED). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VOO achieves a 10.99% return, which is significantly higher than FMED's -4.75% return.

VOO

• 1D: 1.74%
• 1M: 2.12%
• YTD: 10.99%
• 6M: 11.51%
• 1Y: 27.95%
• 3Y*: 21.25%
• 5Y*: 13.93%
• 10Y*: 15.72%

FMED

• 1D: 0.90%
• 1M: 7.10%
• YTD: -4.75%
• 6M: -6.17%
• 1Y: 8.53%
• 3Y*: 0.73%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

VOO vs. FMED - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
VOO Vanguard S&P 500 ETF	10.99%	17.82%	24.98%	11.89%
FMED Fidelity Disruptive Medicine ETF	-4.75%	9.69%	2.29%	-3.59%

Correlation

The correlation between VOO and FMED is 0.59, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.59
Correlation (3Y) Calculated over the trailing 3-year period	0.62
Correlation (All Time) Calculated using the full available price history since Jun 12, 2023	0.62

The correlation between VOO and FMED has been stable across timeframes, ranging from 0.59 to 0.62 - a consistent structural relationship.

VOO vs. FMED - Sectors Allocation Comparison

Sectors	VOO	FMED
Technology	35.6%	0.9%
Financial Services	11.6%	-
Communication Services	11.1%	-
Consumer Cyclical	10.1%	-
Healthcare	8.5%	97.1%
Industrials	8.0%	-
Consumer Defensive	4.9%	-
Energy	3.5%	-
Utilities	2.8%	-
Real Estate	1.9%	-
Basic Materials	1.8%	-

Return for Risk

VOO vs. FMED — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VOO

VOO Risk / Return Rank: 78
VOO Sharpe Ratio Rank: 80
VOO Sortino Ratio Rank: 78
VOO Omega Ratio Rank: 79
VOO Calmar Ratio Rank: 69
VOO Martin Ratio Rank: 81

FMED

FMED Risk / Return Rank: 15
FMED Sharpe Ratio Rank: 16
FMED Sortino Ratio Rank: 16
FMED Omega Ratio Rank: 15
FMED Calmar Ratio Rank: 14
FMED Martin Ratio Rank: 14

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

VOO vs. FMED - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vanguard S&P 500 ETF (VOO) and Fidelity Disruptive Medicine ETF (FMED). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	VOO	FMED	Difference
Sharpe ratio: Return per unit of total volatility	2.28	0.44	+1.84
Sortino ratio: Return per unit of downside risk	3.07	0.79	+2.27
Omega ratio: Gain probability vs. loss probability	1.42	1.09	+0.33
Calmar ratio: Return relative to maximum drawdown	3.15	0.47	+2.69
Martin ratio: Return relative to average drawdown	14.25	1.03	+13.22

VOO vs. FMED - Sharpe Ratio Comparison

The current VOO Sharpe Ratio is 2.28, which is higher than the FMED Sharpe Ratio of 0.44. The chart below compares the historical Sharpe Ratios of VOO and FMED, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

VOO vs. FMED - Drawdown Comparison

The maximum VOO drawdown since its inception was -33.99%, which is greater than FMED's maximum drawdown of -21.84%. Use the drawdown chart below to compare losses from any high point for VOO and FMED.

Drawdown Indicators

	VOO	FMED	Difference
Max Drawdown Largest peak-to-trough decline	-33.99%	-21.84%	-12.15%
Max Drawdown (1Y) Largest decline over 1 year	-8.90%	-18.33%	+9.43%
Max Drawdown (3Y) Largest decline over 3 years	-18.69%	-21.84%	+3.15%
Max Drawdown (5Y) Largest decline over 5 years	-24.52%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-33.99%	—	—
Current Drawdown Current decline from peak	-0.63%	-10.64%	+10.01%
Average Drawdown Average peak-to-trough decline	-3.68%	-7.09%	+3.41%
Ulcer Index Depth and duration of drawdowns from previous peaks	1.97%	8.27%	-6.30%

Volatility

VOO vs. FMED - Volatility Comparison

The current volatility for Vanguard S&P 500 ETF (VOO) is 4.61%, while Fidelity Disruptive Medicine ETF (FMED) has a volatility of 7.50%. This indicates that VOO experiences smaller price fluctuations and is considered to be less risky than FMED based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VOO	FMED	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.61%	7.50%	-2.89%
Volatility (6M) Calculated over the trailing 6-month period	9.72%	15.01%	-5.29%
Volatility (1Y) Calculated over the trailing 1-year period	12.34%	19.37%	-7.03%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.90%	18.57%	-1.67%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.05%	18.57%	-0.52%

VOO vs. FMED - Expense Ratio Comparison

VOO has a 0.03% expense ratio, which is lower than FMED's 0.50% expense ratio.

Dividends

VOO vs. FMED - Dividend Comparison

VOO's dividend yield for the trailing twelve months is around 1.03%, while FMED has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FMED Fidelity Disruptive Medicine ETF	0.00%	0.00%	0.46%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.03%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both VOO and FMED in my portfolio?

VOO and FMED have a correlation of 0.59, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VOO or FMED?

FMED has higher volatility (7.50%) compared to VOO (4.61%). In terms of maximum drawdown, VOO dropped -33.99% vs FMED's -21.84%.

Which ETF is better, VOO or FMED?

On 3-year performance, VOO leads with 21.25% vs 0.73% for FMED. On fees, VOO is cheaper at 0.03% per year. On volatility, VOO has been the lower-risk option at 4.61%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, VOO or FMED?

Over the 3-year period, VOO has performed better with a 21.25% return vs 0.73%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, VOO or FMED?

VOO is cheaper with a 0.03% expense ratio, compared with 0.50% for FMED.

Which ETF pays a higher dividend yield, VOO or FMED?

VOO has the higher dividend yield at 1.03%, compared with 0.00% for FMED.

What is the main difference between VOO and FMED?

VOO is categorized as S&P 500, while FMED is Health & Biotech Equities. They also come from different issuers: Vanguard and Fidelity. Their fees differ too: 0.03% for VOO and 0.50% for FMED.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (2.28 vs 0.44), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.