TWST vs. CLPT
TWST (Twist Bioscience Corporation) and CLPT (ClearPoint Neuro, Inc.) are both stocks. Both are in the Healthcare sector — TWST in Diagnostics & Research, CLPT in Medical Devices. Over the past 5 years, TWST returned -5.57%/yr vs -5.77%/yr for CLPT. At a 0.40 correlation, their price movements are largely independent.
Performance
TWST vs. CLPT - Performance Comparison
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Returns By Period
In the year-to-date period, TWST achieves a 128.03% return, which is significantly higher than CLPT's -2.78% return.
TWST
- 1D
- 3.11%
- 1M
- 28.72%
- YTD
- 128.03%
- 6M
- 132.05%
- 1Y
- 134.23%
- 3Y*
- 64.29%
- 5Y*
- -5.57%
- 10Y*
- —
CLPT
- 1D
- 7.52%
- 1M
- 18.96%
- YTD
- -2.78%
- 6M
- -5.54%
- 1Y
- 5.06%
- 3Y*
- 19.65%
- 5Y*
- -5.77%
- 10Y*
- —
TWST vs. CLPT - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | |
|---|---|---|---|---|---|---|---|
TWST Twist Bioscience Corporation | 128.03% | -31.74% | 26.07% | 54.81% | -69.23% | -45.23% | 356.66% |
CLPT ClearPoint Neuro, Inc. | -2.78% | -11.05% | 126.51% | -19.83% | -24.51% | -29.39% | 183.24% |
Correlation
The correlation between TWST and CLPT is 0.35, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.35 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.42 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.43 |
Correlation (All Time) Calculated using the full available price history since Feb 13, 2020 | 0.40 |
Fundamentals
TWST:
$4.46B
CLPT:
$392.97M
TWST:
-$1.33
CLPT:
-$1.01
TWST:
10.79
CLPT:
9.38
TWST:
9.81
CLPT:
20.86
TWST:
$409.48M
CLPT:
$40.61M
TWST:
$213.23M
CLPT:
$25.32M
TWST:
-$58.23M
CLPT:
-$25.05M
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Return for Risk
TWST vs. CLPT — Risk / Return Rank
TWST
CLPT
TWST vs. CLPT - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Twist Bioscience Corporation (TWST) and ClearPoint Neuro, Inc. (CLPT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| TWST | CLPT | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.99 | ||
| Sortino ratioReturn per unit of downside risk | +1.73 | ||
| Omega ratioGain probability vs. loss probability | 1.30 | 1.11 | +0.19 |
| Calmar ratioReturn relative to maximum drawdown | 3.53 | 0.07 | +3.46 |
| Martin ratioReturn relative to average drawdown | 7.49 | 0.11 | +7.38 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| TWST | CLPT | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 2.04 | 0.05 | +1.99 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.07 | -0.07 | 0.00 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.31 | 0.18 | +0.13 |
Drawdowns
TWST vs. CLPT - Drawdown Comparison
The maximum TWST drawdown since its inception was -94.48%, which is greater than CLPT's maximum drawdown of -84.62%. Use the drawdown chart below to compare losses from any high point for TWST and CLPT.
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Drawdown Indicators
| TWST | CLPT | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -94.48% | -84.62% | -9.86% |
Max Drawdown (1Y)Largest decline over 1 year | -38.24% | -70.74% | +32.50% |
Max Drawdown (3Y)Largest decline over 3 years | -58.97% | -70.74% | +11.77% |
Max Drawdown (5Y)Largest decline over 5 years | -91.54% | -79.96% | -11.58% |
Current DrawdownCurrent decline from peak | -65.22% | -55.07% | -10.15% |
Average DrawdownAverage peak-to-trough decline | -58.15% | -53.55% | -4.60% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 17.98% | 45.26% | -27.28% |
Volatility
TWST vs. CLPT - Volatility Comparison
Twist Bioscience Corporation (TWST) and ClearPoint Neuro, Inc. (CLPT) have volatilities of 19.75% and 20.54%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TWST | CLPT | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 19.75% | 20.54% | -0.79% |
Volatility (6M)Calculated over the trailing 6-month period | 47.14% | 61.12% | -13.98% |
Volatility (1Y)Calculated over the trailing 1-year period | 66.14% | 100.84% | -34.70% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 75.77% | 77.78% | -2.01% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 78.41% | 80.18% | -1.77% |
Dividends
TWST vs. CLPT - Dividend Comparison
Neither TWST nor CLPT has paid dividends to shareholders.
Financials
TWST vs. CLPT - Financials Comparison
This section allows you to compare key financial metrics between Twist Bioscience Corporation and ClearPoint Neuro, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
TWST vs. CLPT - Profitability Comparison
TWST - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Twist Bioscience Corporation reported a gross profit of 57.12M and revenue of 110.72M. Therefore, the gross margin over that period was 51.6%.
CLPT - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, ClearPoint Neuro, Inc. reported a gross profit of 7.76M and revenue of 12.13M. Therefore, the gross margin over that period was 64.0%.
TWST - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Twist Bioscience Corporation reported an operating income of -45.86M and revenue of 110.72M, resulting in an operating margin of -41.4%.
CLPT - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, ClearPoint Neuro, Inc. reported an operating income of -8.48M and revenue of 12.13M, resulting in an operating margin of -69.9%.
TWST - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Twist Bioscience Corporation reported a net income of -44.02M and revenue of 110.72M, resulting in a net margin of -39.8%.
CLPT - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, ClearPoint Neuro, Inc. reported a net income of -9.55M and revenue of 12.13M, resulting in a net margin of -78.8%.
Frequently Asked Questions
TWST and CLPT have a correlation of 0.35, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
CLPT has higher volatility (20.54%) compared to TWST (19.75%). In terms of maximum drawdown, TWST dropped -94.48% vs CLPT's -84.62%.
TWST currently has the higher Sharpe Ratio (2.04 vs 0.05), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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