TWST vs. CRSP
TWST (Twist Bioscience Corporation) and CRSP (CRISPR Therapeutics AG) are both stocks. Both are in the Healthcare sector — TWST in Diagnostics & Research, CRSP in Biotechnology. Over the past 5 years, TWST returned -6.65%/yr vs -16.09%/yr for CRSP. A 0.54 correlation means they provide meaningful diversification when combined.
Performance
TWST vs. CRSP - Performance Comparison
Loading charts...
Returns By Period
In the year-to-date period, TWST achieves a 168.51% return, which is significantly higher than CRSP's 3.66% return.
TWST
- 1D
- -2.73%
- 1M
- 40.61%
- YTD
- 168.51%
- 6M
- 142.93%
- 1Y
- 145.87%
- 3Y*
- 70.18%
- 5Y*
- -6.65%
- 10Y*
- —
CRSP
- 1D
- 0.50%
- 1M
- 7.94%
- YTD
- 3.66%
- 6M
- -6.13%
- 1Y
- 22.85%
- 3Y*
- -1.00%
- 5Y*
- -16.09%
- 10Y*
- —
TWST vs. CRSP - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | |
|---|---|---|---|---|---|---|---|---|---|
TWST Twist Bioscience Corporation | 168.51% | -31.74% | 26.07% | 54.81% | -69.23% | -45.23% | 572.81% | -9.05% | 77.62% |
CRSP CRISPR Therapeutics AG | 3.66% | 33.23% | -37.12% | 54.00% | -46.36% | -50.51% | 151.39% | 113.18% | -10.72% |
Correlation
The correlation between TWST and CRSP is 0.49, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.49 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.53 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.60 |
Correlation (All Time) Calculated using the full available price history since Oct 31, 2018 | 0.54 |
The correlation between TWST and CRSP shifts across timeframes, from 0.49 (1 year) to 0.60 (5 years), reflecting how their relationship changes across market environments.
Fundamentals
TWST:
$5.26B
CRSP:
$5.22B
TWST:
-$1.33
CRSP:
-$6.24
TWST:
12.71
CRSP:
1.21K
TWST:
11.55
CRSP:
2.88
TWST:
$409.48M
CRSP:
$4.10M
TWST:
$213.23M
CRSP:
-$171.17M
TWST:
-$58.23M
CRSP:
-$509.21M
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
TWST vs. CRSP — Risk / Return Rank
TWST
CRSP
TWST vs. CRSP - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Twist Bioscience Corporation (TWST) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| TWST | CRSP | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.83 | ||
| Sortino ratioReturn per unit of downside risk | +1.75 | ||
| Omega ratioGain probability vs. loss probability | 1.31 | 1.11 | +0.20 |
| Calmar ratioReturn relative to maximum drawdown | 3.84 | 0.54 | +3.29 |
| Martin ratioReturn relative to average drawdown | 8.14 | 0.89 | +7.25 |
Loading charts...
Drawdowns
TWST vs. CRSP - Drawdown Comparison
The maximum TWST drawdown since its inception was -94.48%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for TWST and CRSP.
Loading charts...
Drawdown Indicators
| TWST | CRSP | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -94.48% | -85.11% | -9.37% |
Max Drawdown (1Y)Largest decline over 1 year | -38.24% | -42.25% | +4.01% |
Max Drawdown (3Y)Largest decline over 3 years | -58.97% | -64.91% | +5.94% |
Max Drawdown (5Y)Largest decline over 5 years | -91.54% | -80.68% | -10.86% |
Current DrawdownCurrent decline from peak | -59.05% | -74.12% | +15.07% |
Average DrawdownAverage peak-to-trough decline | -58.15% | -49.29% | -8.86% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 17.99% | 25.88% | -7.89% |
Volatility
TWST vs. CRSP - Volatility Comparison
Twist Bioscience Corporation (TWST) has a higher volatility of 19.89% compared to CRISPR Therapeutics AG (CRSP) at 17.92%. This indicates that TWST's price experiences larger fluctuations and is considered to be riskier than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading charts...
Volatility by Period
| TWST | CRSP | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 19.89% | 17.92% | +1.97% |
Volatility (6M)Calculated over the trailing 6-month period | 48.60% | 43.95% | +4.65% |
Volatility (1Y)Calculated over the trailing 1-year period | 66.98% | 62.70% | +4.28% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 75.93% | 60.72% | +15.21% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 78.40% | 64.31% | +14.09% |
Dividends
TWST vs. CRSP - Dividend Comparison
Neither TWST nor CRSP has paid dividends to shareholders.
Financials
TWST vs. CRSP - Financials Comparison
This section allows you to compare key financial metrics between Twist Bioscience Corporation and CRISPR Therapeutics AG. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
TWST and CRSP have a correlation of 0.49, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TWST has higher volatility (19.89%) compared to CRSP (17.92%). In terms of maximum drawdown, TWST dropped -94.48% vs CRSP's -85.11%.
TWST currently has the higher Sharpe Ratio (2.20 vs 0.37), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
Find the right allocation for TWST and CRSP
Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Optimizer