TWST vs. CRSP

Last updated Aug 1, 2026

TWST (Twist Bioscience Corporation) and CRSP (CRISPR Therapeutics AG) are both stocks. Both are in the Healthcare sector — TWST in Diagnostics & Research, CRSP in Biotechnology. Over the past 5 years, TWST returned -5.74%/yr vs -16.89%/yr for CRSP. Their 0.54 correlation means they have sometimes moved together and sometimes differently.

Performance

TWST vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Twist Bioscience Corporation (TWST) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TWST achieves a 188.62% return, which is significantly higher than CRSP's -8.49% return.

TWST

• 1D: 0.24%
• 1M: -7.75%
• 6M: 122.91%
• YTD: 188.62%
• 1Y: 171.82%
• 3Y*: 58.73%
• 5Y*: -5.74%
• 10Y*: —
• ALL TIME*: 28.65%

CRSP

• 1D: -0.93%
• 1M: -20.12%
• 6M: -3.94%
• YTD: -8.49%
• 1Y: -14.44%
• 3Y*: -5.25%
• 5Y*: -16.89%
• 10Y*: —
• ALL TIME*: 12.63%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
CRSP CRISPR Therapeutics AG	$77.21M	$89.27M	$90.29M
TWST Twist Bioscience Corporation	$113.24M	$125.54M	$135.60M

TWST vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
TWST Twist Bioscience Corporation	188.62%	-31.74%	26.07%	54.81%	-69.23%	-45.23%	572.81%	-9.05%	77.62%
CRSP CRISPR Therapeutics AG	-8.49%	33.23%	-37.12%	54.00%	-46.36%	-50.51%	151.39%	113.18%	-10.72%

Correlation

The correlation between TWST and CRSP is 0.45, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.45
Correlation (3Y) Balances recent behavior with more history.	0.52
Correlation (5Y) Shows whether the relationship held over a longer period.	0.59
Correlation (All Time) Calculated using the full available price history since Oct 31, 2018	0.54

The correlation between TWST and CRSP shifts across timeframes, from 0.45 (1 year) to 0.59 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap TWST : $5.70B CRSP : $4.63B
EPS TWST : -$1.33 CRSP : -$6.15
PS Ratio TWST : 13.65 CRSP : 1.08K
PB Ratio TWST : 12.41 CRSP : 2.54
Total Revenue (TTM) TWST : $409.48M CRSP : $4.10M
Gross Profit (TTM) TWST : $213.23M CRSP : -$171.17M
EBITDA (TTM) TWST : -$58.23M CRSP : -$509.21M

Return for Risk

TWST vs. CRSP — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

TWST

TWST Risk / Return Rank: 93
TWST Sharpe Ratio Rank: 96
TWST Sortino Ratio Rank: 92
TWST Omega Ratio Rank: 88
TWST Calmar Ratio Rank: 97
TWST Martin Ratio Rank: 95

CRSP

CRSP Risk / Return Rank: 34
CRSP Sharpe Ratio Rank: 33
CRSP Sortino Ratio Rank: 34
CRSP Omega Ratio Rank: 34
CRSP Calmar Ratio Rank: 33
CRSP Martin Ratio Rank: 35

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

TWST vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Twist Bioscience Corporation (TWST) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	TWST	CRSP	Difference
Sharpe ratio: Return per unit of total volatility	2.53	-0.25	+2.78
Sortino ratio: Return per unit of downside risk	2.97	0.03	+2.94
Omega ratio: Gain probability vs. loss probability	1.34	1.00	+0.33
Calmar ratio: Return relative to maximum drawdown	6.15	-0.35	+6.50
Martin ratio: Return relative to average drawdown	14.14	-0.54	+14.68

TWST vs. CRSP - Sharpe Ratio Comparison

The current TWST Sharpe Ratio is 2.53, which is higher than the CRSP Sharpe Ratio of -0.25. The chart below compares the historical Sharpe Ratios of TWST and CRSP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

TWST vs. CRSP - Drawdown Comparison

The maximum TWST drawdown since its inception was -94.48%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for TWST and CRSP.

Drawdown Indicators

	TWST	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-94.48%	-85.11%	-9.37%
Max Drawdown (1Y) Largest decline over 1 year	-28.27%	-42.25%	+13.98%
Max Drawdown (3Y) Largest decline over 3 years	-58.97%	-64.91%	+5.94%
Max Drawdown (5Y) Largest decline over 5 years	-91.54%	-77.31%	-14.23%
Current Drawdown Current decline from peak	-55.98%	-77.15%	+21.17%
Average Drawdown Average peak-to-trough decline	-58.11%	-49.59%	-8.52%
Ulcer Index Depth and duration of drawdowns from previous peaks	12.27%	27.26%	-14.99%

Volatility

TWST vs. CRSP - Volatility Comparison

Twist Bioscience Corporation (TWST) has a higher volatility of 19.68% compared to CRISPR Therapeutics AG (CRSP) at 14.89%. This indicates that TWST's price experiences larger fluctuations and is considered to be riskier than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TWST	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.68%	14.89%	+4.79%
Volatility (6M) Calculated over the trailing 6-month period	50.21%	42.58%	+7.63%
Volatility (1Y) Calculated over the trailing 1-year period	68.91%	58.68%	+10.23%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	76.24%	60.64%	+15.60%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	78.24%	64.15%	+14.09%

Dividends

TWST vs. CRSP - Dividend Comparison

Neither TWST nor CRSP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TWST and CRSP in my portfolio?

TWST and CRSP have a correlation of 0.45, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TWST or CRSP?

TWST has higher volatility (19.68%) compared to CRSP (14.89%). In terms of maximum drawdown, TWST dropped -94.48% vs CRSP's -85.11%.

Which has better risk-adjusted returns?

TWST currently has the higher Sharpe Ratio (2.53 vs -0.25), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.