TWST vs. CRSP

Last updated Apr 2, 2026

Compare and contrast key facts about Twist Bioscience Corporation (TWST) and CRISPR Therapeutics AG (CRSP).

Performance

TWST vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Twist Bioscience Corporation (TWST) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

TWST vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
TWST Twist Bioscience Corporation	56.18%	-31.74%	26.07%	54.81%	-69.23%	-45.23%	572.81%	-9.05%	64.93%
CRSP CRISPR Therapeutics AG	-6.92%	33.23%	-37.12%	54.00%	-46.36%	-50.51%	151.39%	113.18%	-12.82%

Fundamentals

EPS TWST : -$1.26 CRSP : -$5.47
PS Ratio TWST : 7.70 CRSP : 118.44
Total Revenue (TTM) TWST : $391.56M CRSP : $36.75M
Gross Profit (TTM) TWST : $202.13M CRSP : -$130.60M
EBITDA (TTM) TWST : -$60.00M CRSP : -$529.50M

Returns By Period

In the year-to-date period, TWST achieves a 56.18% return, which is significantly higher than CRSP's -6.92% return.

TWST

• 1D: 4.25%
• 1M: 7.95%
• YTD: 56.18%
• 6M: 69.31%
• 1Y: 27.22%
• 3Y*: 48.66%
• 5Y*: -16.52%
• 10Y*: —

CRSP

• 1D: 2.61%
• 1M: -19.68%
• YTD: -6.92%
• 6M: -26.22%
• 1Y: 47.28%
• 3Y*: 2.57%
• 5Y*: -16.38%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

TWST vs. CRSP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TWST

TWST Risk / Return Rank: 54
TWST Sharpe Ratio Rank: 55
TWST Sortino Ratio Rank: 56
TWST Omega Ratio Rank: 52
TWST Calmar Ratio Rank: 56
TWST Martin Ratio Rank: 54

CRSP

CRSP Risk / Return Rank: 64
CRSP Sharpe Ratio Rank: 66
CRSP Sortino Ratio Rank: 67
CRSP Omega Ratio Rank: 62
CRSP Calmar Ratio Rank: 63
CRSP Martin Ratio Rank: 60

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TWST vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Twist Bioscience Corporation (TWST) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TWST	CRSP	Difference
Sharpe ratio Return per unit of total volatility	0.41	0.75	-0.34
Sortino ratio Return per unit of downside risk	1.06	1.50	-0.44
Omega ratio Gain probability vs. loss probability	1.12	1.17	-0.05
Calmar ratio Return relative to maximum drawdown	0.65	1.03	-0.37
Martin ratio Return relative to average drawdown	1.27	2.03	-0.77
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TWST vs. CRSP - Sharpe Ratio Comparison

The current TWST Sharpe Ratio is 0.41, which is lower than the CRSP Sharpe Ratio of 0.75. The chart below compares the historical Sharpe Ratios of TWST and CRSP, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	TWST	CRSP	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.41	0.75	-0.34
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.22	-0.27	+0.05
Sharpe Ratio (All Time) Calculated using the full available price history	0.24	0.22	+0.02

Correlation

The correlation between TWST and CRSP is 0.55, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.

Dividends

TWST vs. CRSP - Dividend Comparison

Neither TWST nor CRSP has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

TWST vs. CRSP - Drawdown Comparison

The maximum TWST drawdown since its inception was -94.48%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for TWST and CRSP.

Drawdown Indicators

	TWST	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-94.48%	-85.11%	-9.37%
Max Drawdown (1Y) Largest decline over 1 year	-40.00%	-42.25%	+2.25%
Max Drawdown (5Y) Largest decline over 5 years	-91.91%	-80.68%	-11.23%
Current Drawdown Current decline from peak	-76.18%	-76.76%	+0.58%
Average Drawdown Average peak-to-trough decline	-57.83%	-48.71%	-9.12%
Ulcer Index Depth and duration of drawdowns from previous peaks	20.68%	21.35%	-0.67%

Volatility

TWST vs. CRSP - Volatility Comparison

Twist Bioscience Corporation (TWST) has a higher volatility of 22.99% compared to CRISPR Therapeutics AG (CRSP) at 18.14%. This indicates that TWST's price experiences larger fluctuations and is considered to be riskier than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TWST	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	22.99%	18.14%	+4.85%
Volatility (6M) Calculated over the trailing 6-month period	49.52%	44.91%	+4.61%
Volatility (1Y) Calculated over the trailing 1-year period	67.44%	63.81%	+3.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	76.11%	60.36%	+15.75%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	78.55%	64.42%	+14.13%

Financials