TNGX vs. PRME

Last updated Apr 1, 2026

Compare and contrast key facts about Tango Therapeutics, Inc. (TNGX) and Prime Medicine Inc. Common Stock (PRME).

Performance

TNGX vs. PRME - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tango Therapeutics, Inc. (TNGX) and Prime Medicine Inc. Common Stock (PRME). The values are adjusted to include any dividend payments, if applicable.

TNGX vs. PRME - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
TNGX Tango Therapeutics, Inc.	136.12%	186.73%	-68.79%	36.55%	6.77%
PRME Prime Medicine Inc. Common Stock	0.29%	18.84%	-67.04%	-52.31%	20.88%

Fundamentals

Market Cap TNGX : $2.43B PRME : $517.68M
EPS TNGX : -$0.90 PRME : -$1.38
PS Ratio TNGX : 37.75 PRME : 109.80
PB Ratio TNGX : 7.02 PRME : 4.28
Total Revenue (TTM) TNGX : $62.38M PRME : $4.63M
Gross Profit (TTM) TNGX : $61.20M PRME : $0.00
EBITDA (TTM) TNGX : -$105.54M PRME : -$195.76M

Returns By Period

In the year-to-date period, TNGX achieves a 136.12% return, which is significantly higher than PRME's 0.29% return.

TNGX

• 1D: 8.90%
• 1M: 87.79%
• YTD: 136.12%
• 6M: 149.05%
• 1Y: 1,427.01%
• 3Y*: 74.31%
• 5Y*: 13.76%
• 10Y*: —

PRME

• 1D: 10.48%
• 1M: -24.68%
• YTD: 0.29%
• 6M: -37.18%
• 1Y: 74.87%
• 3Y*: -34.35%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

TNGX vs. PRME — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TNGX

TNGX Risk / Return Rank: 100
TNGX Sharpe Ratio Rank: 100
TNGX Sortino Ratio Rank: 99
TNGX Omega Ratio Rank: 99
TNGX Calmar Ratio Rank: 100
TNGX Martin Ratio Rank: 100

PRME

PRME Risk / Return Rank: 68
PRME Sharpe Ratio Rank: 65
PRME Sortino Ratio Rank: 74
PRME Omega Ratio Rank: 66
PRME Calmar Ratio Rank: 70
PRME Martin Ratio Rank: 63

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TNGX vs. PRME - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tango Therapeutics, Inc. (TNGX) and Prime Medicine Inc. Common Stock (PRME). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TNGX	PRME	Difference
Sharpe ratio Return per unit of total volatility	12.96	0.67	+12.29
Sortino ratio Return per unit of downside risk	7.03	1.78	+5.25
Omega ratio Gain probability vs. loss probability	1.83	1.19	+0.65
Calmar ratio Return relative to maximum drawdown	48.73	1.42	+47.31
Martin ratio Return relative to average drawdown	136.78	2.29	+134.49
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TNGX vs. PRME - Sharpe Ratio Comparison

The current TNGX Sharpe Ratio is 12.96, which is higher than the PRME Sharpe Ratio of 0.67. The chart below compares the historical Sharpe Ratios of TNGX and PRME, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	TNGX	PRME	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	12.96	0.67	+12.29
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.14	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.15	-0.39	+0.53

Correlation

The correlation between TNGX and PRME is 0.28, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

TNGX vs. PRME - Dividend Comparison

Neither TNGX nor PRME has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

TNGX vs. PRME - Drawdown Comparison

The maximum TNGX drawdown since its inception was -93.64%, roughly equal to the maximum PRME drawdown of -94.55%. Use the drawdown chart below to compare losses from any high point for TNGX and PRME.

Drawdown Indicators

	TNGX	PRME	Difference
Max Drawdown Largest peak-to-trough decline	-93.64%	-94.55%	+0.91%
Max Drawdown (1Y) Largest decline over 1 year	-27.15%	-52.77%	+25.62%
Max Drawdown (5Y) Largest decline over 5 years	-93.64%	—	—
Current Drawdown Current decline from peak	0.00%	-83.52%	+83.52%
Average Drawdown Average peak-to-trough decline	-49.30%	-64.37%	+15.07%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.67%	32.70%	-23.03%

Volatility

TNGX vs. PRME - Volatility Comparison

Tango Therapeutics, Inc. (TNGX) has a higher volatility of 33.52% compared to Prime Medicine Inc. Common Stock (PRME) at 21.00%. This indicates that TNGX's price experiences larger fluctuations and is considered to be riskier than PRME based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TNGX	PRME	Difference
Volatility (1M) Calculated over the trailing 1-month period	33.52%	21.00%	+12.52%
Volatility (6M) Calculated over the trailing 6-month period	63.26%	66.76%	-3.50%
Volatility (1Y) Calculated over the trailing 1-year period	111.67%	112.28%	-0.61%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	98.22%	91.01%	+7.21%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	93.71%	91.01%	+2.70%

Financials