TMO vs. MSFT
TMO (Thermo Fisher Scientific Inc.) and MSFT (Microsoft Corporation) are both stocks. TMO operates in Diagnostics & Research (Healthcare), while MSFT operates in Software - Infrastructure (Technology). Over the past 10 years, TMO returned 12.54%/yr vs 24.39%/yr for MSFT. At a 0.34 correlation, their price movements are largely independent.
Performance
TMO vs. MSFT - Performance Comparison
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Returns By Period
The year-to-date returns for both investments are quite close, with TMO having a -18.92% return and MSFT slightly higher at -18.85%. Over the past 10 years, TMO has underperformed MSFT with an annualized return of 12.54%, while MSFT has yielded a comparatively higher 24.39% annualized return.
TMO
- 1D
- -1.33%
- 1M
- 5.23%
- YTD
- -18.92%
- 6M
- -17.84%
- 1Y
- 13.42%
- 3Y*
- -3.43%
- 5Y*
- 0.45%
- 10Y*
- 12.54%
MSFT
- 1D
- 0.10%
- 1M
- -3.36%
- YTD
- -18.85%
- 6M
- -17.98%
- 1Y
- -17.75%
- 3Y*
- 6.16%
- 5Y*
- 9.56%
- 10Y*
- 24.39%
TMO vs. MSFT - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
TMO Thermo Fisher Scientific Inc. | -18.92% | 11.78% | -1.72% | -3.36% | -17.29% | 43.54% | 43.72% | 45.55% | 18.21% | 35.03% |
MSFT Microsoft Corporation | -18.85% | 15.58% | 12.93% | 58.19% | -28.02% | 52.48% | 42.53% | 57.56% | 20.80% | 40.73% |
Correlation
The correlation between TMO and MSFT is 0.15, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.15 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.18 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.36 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.44 |
Correlation (All Time) Calculated using the full available price history since Sep 1, 1987 | 0.34 |
The correlation between TMO and MSFT shifts across timeframes, from 0.15 (1 year) to 0.44 (10 years), reflecting how their relationship changes across market environments.
Fundamentals
TMO:
$175.06B
MSFT:
$2.91T
TMO:
$18.22
MSFT:
$16.79
TMO:
25.76
MSFT:
23.27
TMO:
3.91
MSFT:
9.16
TMO:
3.37
MSFT:
7.02
TMO:
$45.20B
MSFT:
$318.27B
TMO:
$17.81B
MSFT:
$217.41B
TMO:
$11.16B
MSFT:
$200.96B
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Return for Risk
TMO vs. MSFT — Risk / Return Rank
TMO
MSFT
TMO vs. MSFT - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Thermo Fisher Scientific Inc. (TMO) and Microsoft Corporation (MSFT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| TMO | MSFT | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.13 | ||
| Sortino ratioReturn per unit of downside risk | +1.71 | ||
| Omega ratioGain probability vs. loss probability | 1.10 | 0.89 | +0.21 |
| Calmar ratioReturn relative to maximum drawdown | 0.43 | -0.53 | +0.95 |
| Martin ratioReturn relative to average drawdown | 0.93 | -1.08 | +2.01 |
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Drawdowns
TMO vs. MSFT - Drawdown Comparison
The maximum TMO drawdown since its inception was -71.16%, roughly equal to the maximum MSFT drawdown of -69.38%. Use the drawdown chart below to compare losses from any high point for TMO and MSFT.
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Drawdown Indicators
| TMO | MSFT | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -71.16% | -69.38% | -1.78% |
Max Drawdown (1Y)Largest decline over 1 year | -31.38% | -33.91% | +2.53% |
Max Drawdown (3Y)Largest decline over 3 years | -37.28% | -33.91% | -3.37% |
Max Drawdown (5Y)Largest decline over 5 years | -40.95% | -37.15% | -3.80% |
Max Drawdown (10Y)Largest decline over 10 years | -40.95% | -37.15% | -3.80% |
Current DrawdownCurrent decline from peak | -28.80% | -27.46% | -1.34% |
Average DrawdownAverage peak-to-trough decline | -18.11% | -21.78% | +3.67% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 14.43% | 16.48% | -2.05% |
Volatility
TMO vs. MSFT - Volatility Comparison
Thermo Fisher Scientific Inc. (TMO) and Microsoft Corporation (MSFT) have volatilities of 10.57% and 10.52%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TMO | MSFT | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 10.57% | 10.52% | +0.05% |
Volatility (6M)Calculated over the trailing 6-month period | 22.27% | 22.31% | -0.04% |
Volatility (1Y)Calculated over the trailing 1-year period | 31.48% | 25.42% | +6.06% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 27.20% | 26.66% | +0.54% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 26.38% | 27.06% | -0.68% |
Dividends
TMO vs. MSFT - Dividend Comparison
TMO's dividend yield for the trailing twelve months is around 0.37%, less than MSFT's 0.91% yield.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MSFT Microsoft Corporation | 0.91% | 0.70% | 0.73% | 0.74% | 1.06% | 0.68% | 0.94% | 1.20% | 1.69% | 1.86% | 2.37% | 2.33% |
TMO Thermo Fisher Scientific Inc. | 0.37% | 0.30% | 0.30% | 0.26% | 0.22% | 0.16% | 0.19% | 0.23% | 0.30% | 0.32% | 0.43% | 0.42% |
Financials
TMO vs. MSFT - Financials Comparison
This section allows you to compare key financial metrics between Thermo Fisher Scientific Inc. and Microsoft Corporation. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
TMO vs. MSFT - Profitability Comparison
TMO - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Thermo Fisher Scientific Inc. reported a gross profit of 4.48B and revenue of 11.01B. Therefore, the gross margin over that period was 40.7%.
MSFT - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Microsoft Corporation reported a gross profit of 56.06B and revenue of 82.89B. Therefore, the gross margin over that period was 67.6%.
TMO - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Thermo Fisher Scientific Inc. reported an operating income of 1.86B and revenue of 11.01B, resulting in an operating margin of 16.9%.
MSFT - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Microsoft Corporation reported an operating income of 38.40B and revenue of 82.89B, resulting in an operating margin of 46.3%.
TMO - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Thermo Fisher Scientific Inc. reported a net income of 1.65B and revenue of 11.01B, resulting in a net margin of 15.0%.
MSFT - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Microsoft Corporation reported a net income of 31.78B and revenue of 82.89B, resulting in a net margin of 38.3%.
Frequently Asked Questions
TMO and MSFT have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TMO has higher volatility (10.57%) compared to MSFT (10.52%). In terms of maximum drawdown, TMO dropped -71.16% vs MSFT's -69.38%.
TMO currently has the higher Sharpe Ratio (0.43 vs -0.70), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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