TMO vs. ORLY

Last updated Jun 3, 2026

TMO (Thermo Fisher Scientific Inc.) and ORLY (O'Reilly Automotive, Inc.) are both stocks. TMO operates in Diagnostics & Research (Healthcare), while ORLY operates in Specialty Retail (Consumer Cyclical). Over the past 10 years, TMO returned 12.49%/yr vs 17.42%/yr for ORLY. At a 0.26 correlation, their price movements are largely independent.

Performance

TMO vs. ORLY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Thermo Fisher Scientific Inc. (TMO) and O'Reilly Automotive, Inc. (ORLY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TMO achieves a -16.72% return, which is significantly lower than ORLY's -5.46% return. Over the past 10 years, TMO has underperformed ORLY with an annualized return of 12.49%, while ORLY has yielded a comparatively higher 17.42% annualized return.

TMO

• 1D: -2.42%
• 1M: 2.74%
• YTD: -16.72%
• 6M: -16.79%
• 1Y: 22.04%
• 3Y*: -2.20%
• 5Y*: 1.87%
• 10Y*: 12.49%

ORLY

• 1D: -0.47%
• 1M: -10.80%
• YTD: -5.46%
• 6M: -13.63%
• 1Y: -5.63%
• 3Y*: 13.05%
• 5Y*: 19.61%
• 10Y*: 17.42%

*Multi-year figures are annualized to reflect compound growth (CAGR)

TMO vs. ORLY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
TMO Thermo Fisher Scientific Inc.	-16.72%	11.78%	-1.72%	-3.36%	-17.29%	43.54%	43.72%	45.55%	18.21%	35.03%
ORLY O'Reilly Automotive, Inc.	-5.46%	15.38%	24.81%	12.56%	19.51%	56.05%	3.27%	27.28%	43.15%	-13.60%

Correlation

The correlation between TMO and ORLY is 0.13, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.13
Correlation (3Y) Calculated over the trailing 3-year period	0.18
Correlation (5Y) Calculated over the trailing 5-year period	0.24
Correlation (10Y) Calculated over the trailing 10-year period	0.23
Correlation (All Time) Calculated using the full available price history since Apr 26, 1993	0.26

The correlation between TMO and ORLY shifts across timeframes, from 0.13 (1 year) to 0.26 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap TMO : $179.82B ORLY : $72.65B
EPS TMO : $18.22 ORLY : $3.06
PE Ratio TMO : 26.46 ORLY : 28.19
PS Ratio TMO : 4.02 ORLY : 4.03
Total Revenue (TTM) TMO : $45.20B ORLY : $18.21B
Gross Profit (TTM) TMO : $17.81B ORLY : $9.40B
EBITDA (TTM) TMO : $11.16B ORLY : $3.96B

Return for Risk

TMO vs. ORLY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TMO

TMO Risk / Return Rank: 58
TMO Sharpe Ratio Rank: 64
TMO Sortino Ratio Rank: 59
TMO Omega Ratio Rank: 57
TMO Calmar Ratio Rank: 55
TMO Martin Ratio Rank: 55

ORLY

ORLY Risk / Return Rank: 28
ORLY Sharpe Ratio Rank: 30
ORLY Sortino Ratio Rank: 25
ORLY Omega Ratio Rank: 26
ORLY Calmar Ratio Rank: 31
ORLY Martin Ratio Rank: 31

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TMO vs. ORLY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Thermo Fisher Scientific Inc. (TMO) and O'Reilly Automotive, Inc. (ORLY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TMO	ORLY	Difference
Sharpe ratio Return per unit of total volatility	0.72	-0.25	+0.97
Sortino ratio Return per unit of downside risk	1.25	-0.21	+1.46
Omega ratio Gain probability vs. loss probability	1.15	0.98	+0.18
Calmar ratio Return relative to maximum drawdown	0.64	-0.27	+0.91
Martin ratio Return relative to average drawdown	1.47	-0.52	+1.99
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TMO vs. ORLY - Sharpe Ratio Comparison

The current TMO Sharpe Ratio is 0.72, which is higher than the ORLY Sharpe Ratio of -0.25. The chart below compares the historical Sharpe Ratios of TMO and ORLY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TMO	ORLY	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.72	-0.25	+0.97
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.07	0.87	-0.80
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.48	0.66	-0.18
Sharpe Ratio (All Time) Calculated using the full available price history	0.40	0.64	-0.24

Drawdowns

TMO vs. ORLY - Drawdown Comparison

The maximum TMO drawdown since its inception was -71.16%, which is greater than ORLY's maximum drawdown of -65.42%. Use the drawdown chart below to compare losses from any high point for TMO and ORLY.

Drawdown Indicators

	TMO	ORLY	Difference
Max Drawdown Largest peak-to-trough decline	-71.16%	-65.42%	-5.74%
Max Drawdown (1Y) Largest decline over 1 year	-31.38%	-20.02%	-11.36%
Max Drawdown (3Y) Largest decline over 3 years	-37.28%	-20.02%	-17.26%
Max Drawdown (5Y) Largest decline over 5 years	-40.95%	-23.03%	-17.92%
Max Drawdown (10Y) Largest decline over 10 years	-40.95%	-42.00%	+1.05%
Current Drawdown Current decline from peak	-26.87%	-20.02%	-6.85%
Average Drawdown Average peak-to-trough decline	-18.01%	-10.78%	-7.23%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.71%	10.35%	+3.36%

Volatility

TMO vs. ORLY - Volatility Comparison

Thermo Fisher Scientific Inc. (TMO) has a higher volatility of 9.66% compared to O'Reilly Automotive, Inc. (ORLY) at 6.71%. This indicates that TMO's price experiences larger fluctuations and is considered to be riskier than ORLY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TMO	ORLY	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.66%	6.71%	+2.95%
Volatility (6M) Calculated over the trailing 6-month period	21.40%	17.99%	+3.41%
Volatility (1Y) Calculated over the trailing 1-year period	30.90%	22.83%	+8.07%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	27.11%	22.60%	+4.51%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	26.31%	26.51%	-0.20%

Dividends

TMO vs. ORLY - Dividend Comparison

TMO's dividend yield for the trailing twelve months is around 0.37%, while ORLY has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ORLY O'Reilly Automotive, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
TMO Thermo Fisher Scientific Inc.	0.37%	0.30%	0.30%	0.26%	0.22%	0.16%	0.19%	0.23%	0.30%	0.32%	0.43%	0.42%

Financials

TMO vs. ORLY - Profitability Comparison

The chart below illustrates the profitability comparison between Thermo Fisher Scientific Inc. and O'Reilly Automotive, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

TMO - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Thermo Fisher Scientific Inc. reported a gross profit of 4.48B and revenue of 11.01B. Therefore, the gross margin over that period was 40.7%.

ORLY - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, O'Reilly Automotive, Inc. reported a gross profit of 2.35B and revenue of 4.56B. Therefore, the gross margin over that period was 51.5%.

TMO - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Thermo Fisher Scientific Inc. reported an operating income of 1.86B and revenue of 11.01B, resulting in an operating margin of 16.9%.

ORLY - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, O'Reilly Automotive, Inc. reported an operating income of 841.61M and revenue of 4.56B, resulting in an operating margin of 18.5%.

TMO - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Thermo Fisher Scientific Inc. reported a net income of 1.65B and revenue of 11.01B, resulting in a net margin of 15.0%.

ORLY - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, O'Reilly Automotive, Inc. reported a net income of 604.18M and revenue of 4.56B, resulting in a net margin of 13.3%.

Frequently Asked Questions

Can I hold both TMO and ORLY in my portfolio?

TMO and ORLY have a correlation of 0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TMO or ORLY?

TMO has higher volatility (9.66%) compared to ORLY (6.71%). In terms of maximum drawdown, TMO dropped -71.16% vs ORLY's -65.42%.

Which has better risk-adjusted returns?

TMO currently has the higher Sharpe Ratio (0.72 vs -0.25), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.