THISX vs. VOO

Last updated Jun 24, 2026

THISX (T. Rowe Price Health Sciences Fund Class I) and VOO (Vanguard S&P 500 ETF) are both funds - THISX is a Health & Biotech Equities fund actively managed by T. Rowe Price, while VOO is a S&P 500 fund tracking the S&P 500 Index. THISX is actively managed, while VOO is passively managed. Over the past 5 years, THISX returned 5.69%/yr vs 13.13%/yr for VOO. A 0.70 correlation means they provide meaningful diversification when combined. THISX charges 0.67%/yr vs 0.03%/yr for VOO.

Performance

THISX vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in T. Rowe Price Health Sciences Fund Class I (THISX) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, THISX achieves a 0.31% return, which is significantly lower than VOO's 8.19% return.

THISX

• 1D: 1.78%
• 1M: 2.64%
• YTD: 0.31%
• 6M: -0.58%
• 1Y: 23.85%
• 3Y*: 12.26%
• 5Y*: 5.69%
• 10Y*: —

VOO

• 1D: -1.42%
• 1M: -1.34%
• YTD: 8.19%
• 6M: 7.24%
• 1Y: 23.69%
• 3Y*: 20.78%
• 5Y*: 13.13%
• 10Y*: 15.61%

*Multi-year figures are annualized to reflect compound growth (CAGR)

THISX vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
THISX T. Rowe Price Health Sciences Fund Class I	0.31%	17.92%	16.75%	3.17%	-12.11%	13.62%	30.35%	38.29%	1.20%	26.96%
VOO Vanguard S&P 500 ETF	8.19%	17.82%	24.98%	26.32%	-18.17%	28.79%	18.32%	31.37%	-4.50%	21.77%

Correlation

The correlation between THISX and VOO is 0.47, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.47
Correlation (3Y) Calculated over the trailing 3-year period	0.57
Correlation (5Y) Calculated over the trailing 5-year period	0.66
Correlation (All Time) Calculated using the full available price history since Jan 3, 2017	0.70

Over the past year, the correlation between THISX and VOO has dropped to 0.47 - well below their long-term average of 0.70, suggesting their price drivers have been diverging.

Return for Risk

THISX vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

THISX

THISX Risk / Return Rank: 31
THISX Sharpe Ratio Rank: 34
THISX Sortino Ratio Rank: 36
THISX Omega Ratio Rank: 30
THISX Calmar Ratio Rank: 30
THISX Martin Ratio Rank: 24

VOO

VOO Risk / Return Rank: 59
VOO Sharpe Ratio Rank: 59
VOO Sortino Ratio Rank: 56
VOO Omega Ratio Rank: 58
VOO Calmar Ratio Rank: 56
VOO Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

THISX vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for T. Rowe Price Health Sciences Fund Class I (THISX) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	THISX	VOO	Difference
Sharpe ratio: Return per unit of total volatility	1.56	1.91	-0.36
Sortino ratio: Return per unit of downside risk	2.32	2.60	-0.28
Omega ratio: Gain probability vs. loss probability	1.27	1.35	-0.08
Calmar ratio: Return relative to maximum drawdown	1.92	2.67	-0.75
Martin ratio: Return relative to average drawdown	5.41	11.96	-6.55

THISX vs. VOO - Sharpe Ratio Comparison

The current THISX Sharpe Ratio is 1.56, which is comparable to the VOO Sharpe Ratio of 1.91. The chart below compares the historical Sharpe Ratios of THISX and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

THISX vs. VOO - Drawdown Comparison

The maximum THISX drawdown since its inception was -28.97%, smaller than the maximum VOO drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for THISX and VOO.

Drawdown Indicators

	THISX	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-28.97%	-33.99%	+5.02%
Max Drawdown (1Y) Largest decline over 1 year	-12.78%	-8.90%	-3.88%
Max Drawdown (3Y) Largest decline over 3 years	-15.80%	-18.69%	+2.89%
Max Drawdown (5Y) Largest decline over 5 years	-27.53%	-24.52%	-3.01%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-2.85%	-3.14%	+0.29%
Average Drawdown Average peak-to-trough decline	-7.16%	-3.68%	-3.48%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.53%	1.99%	+2.54%

Volatility

THISX vs. VOO - Volatility Comparison

T. Rowe Price Health Sciences Fund Class I (THISX) has a higher volatility of 5.39% compared to Vanguard S&P 500 ETF (VOO) at 4.83%. This indicates that THISX's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	THISX	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.39%	4.83%	+0.56%
Volatility (6M) Calculated over the trailing 6-month period	12.30%	9.82%	+2.48%
Volatility (1Y) Calculated over the trailing 1-year period	15.79%	12.46%	+3.33%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	18.48%	16.91%	+1.57%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	19.96%	18.02%	+1.94%

THISX vs. VOO - Expense Ratio Comparison

THISX has a 0.67% expense ratio, which is higher than VOO's 0.03% expense ratio.

Dividends

THISX vs. VOO - Dividend Comparison

THISX's dividend yield for the trailing twelve months is around 12.22%, more than VOO's 1.05% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
THISX T. Rowe Price Health Sciences Fund Class I	12.22%	12.25%	26.10%	5.20%	1.76%	7.62%	7.25%	12.58%	6.70%	7.55%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.05%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both THISX and VOO in my portfolio?

THISX and VOO have a correlation of 0.47, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, THISX or VOO?

THISX has higher volatility (5.39%) compared to VOO (4.83%). In terms of maximum drawdown, THISX dropped -28.97% vs VOO's -33.99%.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (1.91 vs 1.56), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.