SERA vs. VOO

Last updated Aug 1, 2026

SERA (Sera Prognostics, Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 5 years, SERA returned -28.90%/yr vs 12.83%/yr for VOO. Their 0.17 correlation means their historical movements had little consistent relationship.

Performance

SERA vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Sera Prognostics, Inc. (SERA) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SERA achieves a -30.85% return, which is significantly lower than VOO's 10.16% return.

SERA

• 1D: -2.86%
• 1M: 2.00%
• 6M: -26.09%
• YTD: -30.85%
• 1Y: -24.44%
• 3Y*: -11.82%
• 5Y*: -28.90%
• 10Y*: —
• ALL TIME*: -32.68%

VOO

• 1D: 0.71%
• 1M: 0.26%
• 6M: 8.58%
• YTD: 10.16%
• 1Y: 21.58%
• 3Y*: 19.42%
• 5Y*: 12.83%
• 10Y*: 15.14%
• ALL TIME*: 14.78%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
SERA Sera Prognostics, Inc.	$84.85K	$76.50K	$108.59K
VOO Vanguard S&P 500 ETF	$3.82B	$3.78B	$5.44B

SERA vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
SERA Sera Prognostics, Inc.	-30.85%	-63.76%	36.12%	374.60%	-81.66%	-54.23%
VOO Vanguard S&P 500 ETF	10.16%	17.82%	24.98%	26.32%	-18.17%	9.63%

Correlation

The correlation between SERA and VOO is 0.14, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.14
Correlation (3Y) Balances recent behavior with more history.	0.14
Correlation (5Y) Shows whether the relationship held over a longer period.	0.16
Correlation (All Time) Calculated using the full available price history since Jul 15, 2021	0.17

Return for Risk

SERA vs. VOO — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

SERA

SERA Risk / Return Rank: 30
SERA Sharpe Ratio Rank: 29
SERA Sortino Ratio Rank: 32
SERA Omega Ratio Rank: 32
SERA Calmar Ratio Rank: 28
SERA Martin Ratio Rank: 28

VOO

VOO Risk / Return Rank: 68
VOO Sharpe Ratio Rank: 68
VOO Sortino Ratio Rank: 65
VOO Omega Ratio Rank: 66
VOO Calmar Ratio Rank: 64
VOO Martin Ratio Rank: 76

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

SERA vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Sera Prognostics, Inc. (SERA) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	SERA	VOO	Difference
Sharpe ratio: Return per unit of total volatility	-0.35	1.53	-1.88
Sortino ratio: Return per unit of downside risk	-0.03	2.13	-2.17
Omega ratio: Gain probability vs. loss probability	1.00	1.28	-0.28
Calmar ratio: Return relative to maximum drawdown	-0.46	2.21	-2.67
Martin ratio: Return relative to average drawdown	-0.81	9.44	-10.24

SERA vs. VOO - Sharpe Ratio Comparison

The current SERA Sharpe Ratio is -0.35, which is lower than the VOO Sharpe Ratio of 1.53. The chart below compares the historical Sharpe Ratios of SERA and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

SERA vs. VOO - Drawdown Comparison

The maximum SERA drawdown since its inception was -92.27%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for SERA and VOO.

Drawdown Indicators

	SERA	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-92.27%	-33.99%	-58.28%
Max Drawdown (1Y) Largest decline over 1 year	-57.60%	-8.90%	-48.70%
Max Drawdown (3Y) Largest decline over 3 years	-87.25%	-18.69%	-68.56%
Max Drawdown (5Y) Largest decline over 5 years	-91.10%	-24.52%	-66.58%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-86.41%	-1.38%	-85.03%
Average Drawdown Average peak-to-trough decline	-69.63%	-3.67%	-65.96%
Ulcer Index Depth and duration of drawdowns from previous peaks	33.06%	2.08%	+30.98%

Volatility

SERA vs. VOO - Volatility Comparison

Sera Prognostics, Inc. (SERA) has a higher volatility of 20.88% compared to Vanguard S&P 500 ETF (VOO) at 3.54%. This indicates that SERA's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SERA	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.88%	3.54%	+17.34%
Volatility (6M) Calculated over the trailing 6-month period	53.87%	10.10%	+43.77%
Volatility (1Y) Calculated over the trailing 1-year period	77.32%	12.82%	+64.50%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	126.67%	16.93%	+109.74%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	126.81%	18.01%	+108.80%

Dividends

SERA vs. VOO - Dividend Comparison

SERA has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.07%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
SERA Sera Prognostics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.07%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both SERA and VOO in my portfolio?

SERA and VOO have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SERA or VOO?

SERA has higher volatility (20.88%) compared to VOO (3.54%). In terms of maximum drawdown, SERA dropped -92.27% vs VOO's -33.99%.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (1.53 vs -0.35), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.