SERA vs. VOO
SERA (Sera Prognostics, Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 3 years, SERA returned -15.37%/yr vs 21.08%/yr for VOO. At a 0.17 correlation, their price movements are largely independent.
Performance
SERA vs. VOO - Performance Comparison
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Returns By Period
In the year-to-date period, SERA achieves a -33.22% return, which is significantly lower than VOO's 11.31% return.
SERA
- 1D
- -4.37%
- 1M
- 5.35%
- 6M
- -46.61%
- YTD
- -33.22%
- 1Y
- -30.63%
- 3Y*
- -15.37%
- 5Y*
- —
- 10Y*
- —
VOO
- 1D
- 0.46%
- 1M
- 2.04%
- 6M
- 9.36%
- YTD
- 11.31%
- 1Y
- 22.48%
- 3Y*
- 21.08%
- 5Y*
- 13.22%
- 10Y*
- 15.29%
SERA vs. VOO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
SERA Sera Prognostics, Inc. | -33.22% | -63.76% | 36.12% | 374.60% | -81.66% | -54.23% |
VOO Vanguard S&P 500 ETF | 11.31% | 17.82% | 24.98% | 26.32% | -18.17% | 9.63% |
Correlation
The correlation between SERA and VOO is 0.15, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.15 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.14 |
Correlation (All Time) Calculated using the full available price history since Jul 15, 2021 | 0.17 |
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Return for Risk
SERA vs. VOO — Risk / Return Rank
SERA
VOO
SERA vs. VOO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Sera Prognostics, Inc. (SERA) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| SERA | VOO | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -2.15 | ||
| Sortino ratioReturn per unit of downside risk | -2.54 | ||
| Omega ratioGain probability vs. loss probability | 0.99 | 1.32 | -0.33 |
| Calmar ratioReturn relative to maximum drawdown | -0.50 | 2.49 | -2.99 |
| Martin ratioReturn relative to average drawdown | -0.90 | 10.85 | -11.76 |
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Drawdowns
SERA vs. VOO - Drawdown Comparison
The maximum SERA drawdown since its inception was -92.27%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for SERA and VOO.
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Drawdown Indicators
| SERA | VOO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -92.27% | -33.99% | -58.28% |
Max Drawdown (1Y)Largest decline over 1 year | -57.60% | -8.90% | -48.70% |
Max Drawdown (3Y)Largest decline over 3 years | -87.25% | -18.69% | -68.56% |
Max Drawdown (5Y)Largest decline over 5 years | — | -24.52% | — |
Max Drawdown (10Y)Largest decline over 10 years | — | -33.99% | — |
Current DrawdownCurrent decline from peak | -86.88% | -0.34% | -86.54% |
Average DrawdownAverage peak-to-trough decline | -69.44% | -3.68% | -65.76% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 31.78% | 2.04% | +29.74% |
Volatility
SERA vs. VOO - Volatility Comparison
Sera Prognostics, Inc. (SERA) has a higher volatility of 18.94% compared to Vanguard S&P 500 ETF (VOO) at 4.42%. This indicates that SERA's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SERA | VOO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 18.94% | 4.42% | +14.52% |
Volatility (6M)Calculated over the trailing 6-month period | 52.48% | 9.94% | +42.54% |
Volatility (1Y)Calculated over the trailing 1-year period | 76.96% | 12.48% | +64.48% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 127.28% | 16.92% | +110.36% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 127.28% | 17.99% | +109.29% |
Dividends
SERA vs. VOO - Dividend Comparison
SERA has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.06%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SERA Sera Prognostics, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
VOO Vanguard S&P 500 ETF | 1.06% | 1.13% | 1.24% | 1.46% | 1.69% | 1.25% | 1.54% | 1.88% | 2.06% | 1.78% | 2.02% | 2.10% |
Frequently Asked Questions
SERA and VOO have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
SERA has higher volatility (18.94%) compared to VOO (4.42%). In terms of maximum drawdown, SERA dropped -92.27% vs VOO's -33.99%.
VOO currently has the higher Sharpe Ratio (1.77 vs -0.37), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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