RFFC vs. SBIO

Last updated Jun 4, 2026

RFFC (ALPS Active Equity Opportunity ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both exchange-traded funds - RFFC is a Large Cap Blend Equities fund actively managed by SS&C, while SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index. RFFC is actively managed, while SBIO is passively managed. Over the past 5 years, RFFC returned 12.38%/yr vs 2.68%/yr for SBIO. A 0.55 correlation means they provide meaningful diversification when combined. RFFC charges 0.48%/yr vs 0.50%/yr for SBIO.

Performance

RFFC vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALPS Active Equity Opportunity ETF (RFFC) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, RFFC achieves a 10.59% return, which is significantly higher than SBIO's -0.39% return.

RFFC

• 1D: -0.47%
• 1M: 3.42%
• YTD: 10.59%
• 6M: 10.88%
• 1Y: 28.37%
• 3Y*: 21.20%
• 5Y*: 12.38%
• 10Y*: —

SBIO

• 1D: 1.41%
• 1M: -7.56%
• YTD: -0.39%
• 6M: 3.05%
• 1Y: 65.41%
• 3Y*: 17.80%
• 5Y*: 2.68%
• 10Y*: 8.02%

*Multi-year figures are annualized to reflect compound growth (CAGR)

RFFC vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
RFFC ALPS Active Equity Opportunity ETF	10.59%	16.83%	23.51%	19.50%	-14.58%	22.33%	12.48%	24.77%	-10.23%	21.02%
SBIO ALPS Medical Breakthroughs ETF	-0.39%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Correlation

The correlation between RFFC and SBIO is 0.47, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.47
Correlation (3Y) Calculated over the trailing 3-year period	0.50
Correlation (5Y) Calculated over the trailing 5-year period	0.54
Correlation (All Time) Calculated using the full available price history since Jun 8, 2016	0.55

The correlation between RFFC and SBIO has been stable across timeframes, ranging from 0.47 to 0.55 - a consistent structural relationship.

RFFC vs. SBIO - Sectors Allocation Comparison

Sectors	RFFC	SBIO
Technology	29.8%	-
Industrials	13.2%	-
Healthcare	11.8%	100.0%
Financial Services	11.5%	-0.0%
Consumer Cyclical	9.9%	-
Communication Services	9.2%	-
Energy	4.4%	-
Consumer Defensive	3.1%	-
Utilities	2.6%	-
Basic Materials	2.3%	-
Real Estate	2.2%	-

Return for Risk

RFFC vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

RFFC

RFFC Risk / Return Rank: 71
RFFC Sharpe Ratio Rank: 73
RFFC Sortino Ratio Rank: 75
RFFC Omega Ratio Rank: 71
RFFC Calmar Ratio Rank: 62
RFFC Martin Ratio Rank: 75

SBIO

SBIO Risk / Return Rank: 72
SBIO Sharpe Ratio Rank: 67
SBIO Sortino Ratio Rank: 67
SBIO Omega Ratio Rank: 59
SBIO Calmar Ratio Rank: 88
SBIO Martin Ratio Rank: 79

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

RFFC vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALPS Active Equity Opportunity ETF (RFFC) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	RFFC	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	2.38	2.24	+0.13
Sortino ratio: Return per unit of downside risk	3.36	3.10	+0.26
Omega ratio: Gain probability vs. loss probability	1.42	1.36	+0.06
Calmar ratio: Return relative to maximum drawdown	3.08	5.19	-2.11
Martin ratio: Return relative to average drawdown	14.17	15.57	-1.39
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

RFFC vs. SBIO - Sharpe Ratio Comparison

The current RFFC Sharpe Ratio is 2.38, which is comparable to the SBIO Sharpe Ratio of 2.24. The chart below compares the historical Sharpe Ratios of RFFC and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	RFFC	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.38	2.24	+0.13
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.77	0.08	+0.68
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.24	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.71	0.21	+0.50

Drawdowns

RFFC vs. SBIO - Drawdown Comparison

The maximum RFFC drawdown since its inception was -36.26%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for RFFC and SBIO.

Drawdown Indicators

	RFFC	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-36.26%	-63.06%	+26.80%
Max Drawdown (1Y) Largest decline over 1 year	-9.25%	-12.66%	+3.41%
Max Drawdown (3Y) Largest decline over 3 years	-18.45%	-42.44%	+23.99%
Max Drawdown (5Y) Largest decline over 5 years	-22.29%	-53.10%	+30.81%
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-0.54%	-16.79%	+16.25%
Average Drawdown Average peak-to-trough decline	-5.02%	-28.45%	+23.43%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.01%	4.22%	-2.21%

Volatility

RFFC vs. SBIO - Volatility Comparison

The current volatility for ALPS Active Equity Opportunity ETF (RFFC) is 3.00%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 9.48%. This indicates that RFFC experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	RFFC	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	3.00%	9.48%	-6.48%
Volatility (6M) Calculated over the trailing 6-month period	9.32%	22.70%	-13.38%
Volatility (1Y) Calculated over the trailing 1-year period	12.00%	29.42%	-17.42%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.27%	33.56%	-17.29%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.97%	33.17%	-15.20%

RFFC vs. SBIO - Expense Ratio Comparison

RFFC has a 0.48% expense ratio, which is lower than SBIO's 0.50% expense ratio.

Dividends

RFFC vs. SBIO - Dividend Comparison

RFFC's dividend yield for the trailing twelve months is around 0.72%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016
RFFC ALPS Active Equity Opportunity ETF	0.72%	0.78%	1.05%	1.35%	1.41%	0.71%	1.79%	1.34%	1.36%	0.93%	0.66%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%

Frequently Asked Questions

Can I hold both RFFC and SBIO in my portfolio?

RFFC and SBIO have a correlation of 0.47, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, RFFC or SBIO?

SBIO has higher volatility (9.48%) compared to RFFC (3.00%). In terms of maximum drawdown, RFFC dropped -36.26% vs SBIO's -63.06%.

Which ETF is better, RFFC or SBIO?

On 5-year performance, RFFC leads with 12.38% vs 2.68% for SBIO. On fees, RFFC is cheaper at 0.48% per year. On volatility, RFFC has been the lower-risk option at 3.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, RFFC or SBIO?

Over the 5-year period, RFFC has performed better with a 12.38% return vs 2.68%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, RFFC or SBIO?

RFFC is cheaper with a 0.48% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, RFFC or SBIO?

RFFC has the higher dividend yield at 0.72%, compared with 0.00% for SBIO.

What is the main difference between RFFC and SBIO?

RFFC is categorized as Large Cap Blend Equities, while SBIO is Health & Biotech Equities. Their fees differ too: 0.48% for RFFC and 0.50% for SBIO.

Which has better risk-adjusted returns?

RFFC currently has the higher Sharpe Ratio (2.38 vs 2.24), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.