ACET vs. CRSP

Last updated Jun 4, 2026

ACET (Adicet Bio, Inc.) and CRSP (CRISPR Therapeutics AG) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, ACET returned -47.50%/yr vs -14.40%/yr for CRSP. At a 0.32 correlation, their price movements are largely independent.

Performance

ACET vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Adicet Bio, Inc. (ACET) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACET achieves a -7.01% return, which is significantly lower than CRSP's -0.69% return.

ACET

• 1D: -3.45%
• 1M: -7.34%
• YTD: -7.01%
• 6M: -8.87%
• 1Y: -37.18%
• 3Y*: -54.94%
• 5Y*: -47.50%
• 10Y*: —

CRSP

• 1D: 0.12%
• 1M: -2.80%
• YTD: -0.69%
• 6M: -6.98%
• 1Y: 36.91%
• 3Y*: -7.12%
• 5Y*: -14.40%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ACET vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
ACET Adicet Bio, Inc.	-7.01%	-45.30%	-49.10%	-78.86%	-48.89%	24.48%	34.71%	-82.71%	-48.93%
CRSP CRISPR Therapeutics AG	-0.69%	33.23%	-37.12%	54.00%	-46.36%	-50.51%	151.39%	113.18%	-27.58%

Correlation

The correlation between ACET and CRSP is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.31
Correlation (3Y) Calculated over the trailing 3-year period	0.32
Correlation (5Y) Calculated over the trailing 5-year period	0.38
Correlation (All Time) Calculated using the full available price history since Jan 29, 2018	0.32

Fundamentals

Market Cap ACET : $84.13M CRSP : $5.00B
EPS ACET : -$15.00 CRSP : -$6.24
PB Ratio ACET : 0.60 CRSP : 2.76
Total Revenue (TTM) ACET : $0.00 CRSP : $4.10M
Gross Profit (TTM) ACET : -$1.47M CRSP : -$171.17M
EBITDA (TTM) ACET : -$110.77M CRSP : -$509.21M

Return for Risk

ACET vs. CRSP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ACET

ACET Risk / Return Rank: 21
ACET Sharpe Ratio Rank: 19
ACET Sortino Ratio Rank: 22
ACET Omega Ratio Rank: 23
ACET Calmar Ratio Rank: 20
ACET Martin Ratio Rank: 23

CRSP

CRSP Risk / Return Rank: 58
CRSP Sharpe Ratio Rank: 60
CRSP Sortino Ratio Rank: 60
CRSP Omega Ratio Rank: 56
CRSP Calmar Ratio Rank: 59
CRSP Martin Ratio Rank: 55

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ACET vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Adicet Bio, Inc. (ACET) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ACET	CRSP	Difference
Sharpe ratio: Return per unit of total volatility	-0.50	0.60	-1.10
Sortino ratio: Return per unit of downside risk	-0.37	1.28	-1.65
Omega ratio: Gain probability vs. loss probability	0.96	1.15	-0.19
Calmar ratio: Return relative to maximum drawdown	-0.59	0.88	-1.47
Martin ratio: Return relative to average drawdown	-0.92	1.49	-2.40
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ACET vs. CRSP - Sharpe Ratio Comparison

The current ACET Sharpe Ratio is -0.50, which is lower than the CRSP Sharpe Ratio of 0.60. The chart below compares the historical Sharpe Ratios of ACET and CRSP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ACET	CRSP	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.50	0.60	-1.10
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.53	-0.24	-0.29
Sharpe Ratio (All Time) Calculated using the full available price history	-0.51	0.23	-0.74

Drawdowns

ACET vs. CRSP - Drawdown Comparison

The maximum ACET drawdown since its inception was -99.74%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for ACET and CRSP.

Drawdown Indicators

	ACET	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-99.74%	-85.11%	-14.63%
Max Drawdown (1Y) Largest decline over 1 year	-63.28%	-42.25%	-21.03%
Max Drawdown (3Y) Largest decline over 3 years	-93.31%	-64.91%	-28.40%
Max Drawdown (5Y) Largest decline over 5 years	-98.20%	-80.68%	-17.52%
Current Drawdown Current decline from peak	-99.66%	-75.20%	-24.46%
Average Drawdown Average peak-to-trough decline	-85.32%	-49.17%	-36.15%
Ulcer Index Depth and duration of drawdowns from previous peaks	40.50%	24.92%	+15.58%

Volatility

ACET vs. CRSP - Volatility Comparison

Adicet Bio, Inc. (ACET) has a higher volatility of 20.67% compared to CRISPR Therapeutics AG (CRSP) at 14.90%. This indicates that ACET's price experiences larger fluctuations and is considered to be riskier than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACET	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.67%	14.90%	+5.77%
Volatility (6M) Calculated over the trailing 6-month period	49.61%	42.49%	+7.12%
Volatility (1Y) Calculated over the trailing 1-year period	74.31%	61.68%	+12.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	90.77%	60.46%	+30.31%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	93.79%	64.27%	+29.52%

Dividends

ACET vs. CRSP - Dividend Comparison

Neither ACET nor CRSP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACET and CRSP in my portfolio?

ACET and CRSP have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACET or CRSP?

ACET has higher volatility (20.67%) compared to CRSP (14.90%). In terms of maximum drawdown, ACET dropped -99.74% vs CRSP's -85.11%.

Which has better risk-adjusted returns?

CRSP currently has the higher Sharpe Ratio (0.60 vs -0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.