QDEL vs. PB

Last updated Jul 11, 2026

QDEL (Quidel Corporation) and PB (Prosperity Bancshares, Inc.) are both stocks. QDEL operates in Diagnostics & Research (Healthcare), while PB operates in Banks - Regional (Financial Services). Over the past 10 years, QDEL returned -1.00%/yr vs 6.27%/yr for PB. At a 0.24 correlation, their price movements are largely independent.

Performance

QDEL vs. PB - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Quidel Corporation (QDEL) and Prosperity Bancshares, Inc. (PB). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, QDEL achieves a -36.03% return, which is significantly lower than PB's 6.01% return. Over the past 10 years, QDEL has underperformed PB with an annualized return of -1.00%, while PB has yielded a comparatively higher 6.27% annualized return.

QDEL

• 1D: 4.76%
• 1M: 29.30%
• 6M: -45.70%
• YTD: -36.03%
• 1Y: -39.78%
• 3Y*: -40.42%
• 5Y*: -31.71%
• 10Y*: -1.00%

PB

• 1D: 0.69%
• 1M: -0.11%
• 6M: 1.04%
• YTD: 6.01%
• 1Y: 0.94%
• 3Y*: 11.85%
• 5Y*: 3.42%
• 10Y*: 6.27%

*Multi-year figures are annualized to reflect compound growth (CAGR)

QDEL vs. PB - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
QDEL Quidel Corporation	-36.03%	-35.89%	-39.55%	-13.97%	-36.54%	-24.86%	139.44%	53.69%	12.62%	102.38%
PB Prosperity Bancshares, Inc.	6.01%	-5.15%	15.06%	-3.34%	3.64%	7.13%	-0.27%	18.19%	-9.22%	-0.37%

Correlation

The correlation between QDEL and PB is 0.25, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.25
Correlation (3Y) Calculated over the trailing 3-year period	0.30
Correlation (5Y) Calculated over the trailing 5-year period	0.26
Correlation (10Y) Calculated over the trailing 10-year period	0.20
Correlation (All Time) Calculated using the full available price history since Nov 12, 1998	0.24

Fundamentals

Market Cap QDEL : $1.25B PB : $7.26B
EPS QDEL : -$17.81 PB : $5.48
PS Ratio QDEL : 0.47 PB : 5.38
Total Revenue (TTM) QDEL : $2.66B PB : $1.29B
Gross Profit (TTM) QDEL : $1.50B PB : $930.60M
EBITDA (TTM) QDEL : -$662.00M PB : $674.35M

Return for Risk

QDEL vs. PB — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

QDEL

QDEL Risk / Return Rank: 24
QDEL Sharpe Ratio Rank: 23
QDEL Sortino Ratio Rank: 27
QDEL Omega Ratio Rank: 26
QDEL Calmar Ratio Rank: 23
QDEL Martin Ratio Rank: 20

PB

PB Risk / Return Rank: 42
PB Sharpe Ratio Rank: 45
PB Sortino Ratio Rank: 38
PB Omega Ratio Rank: 37
PB Calmar Ratio Rank: 45
PB Martin Ratio Rank: 44

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

QDEL vs. PB - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Quidel Corporation (QDEL) and Prosperity Bancshares, Inc. (PB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	QDEL	PB	Difference
Sharpe ratio: Return per unit of total volatility	-0.50	-0.01	-0.48
Sortino ratio: Return per unit of downside risk	-0.30	0.14	-0.44
Omega ratio: Gain probability vs. loss probability	0.96	1.02	-0.06
Calmar ratio: Return relative to maximum drawdown	-0.59	-0.02	-0.57
Martin ratio: Return relative to average drawdown	-1.11	-0.03	-1.07

QDEL vs. PB - Sharpe Ratio Comparison

The current QDEL Sharpe Ratio is -0.50, which is lower than the PB Sharpe Ratio of -0.01. The chart below compares the historical Sharpe Ratios of QDEL and PB, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

QDEL vs. PB - Drawdown Comparison

The maximum QDEL drawdown since its inception was -96.70%, which is greater than PB's maximum drawdown of -47.89%. Use the drawdown chart below to compare losses from any high point for QDEL and PB.

Drawdown Indicators

	QDEL	PB	Difference
Max Drawdown Largest peak-to-trough decline	-96.70%	-47.89%	-48.81%
Max Drawdown (1Y) Largest decline over 1 year	-71.85%	-16.28%	-55.57%
Max Drawdown (3Y) Largest decline over 3 years	-88.76%	-24.84%	-63.92%
Max Drawdown (5Y) Largest decline over 5 years	-94.30%	-34.37%	-59.93%
Max Drawdown (10Y) Largest decline over 10 years	-96.70%	-42.24%	-54.46%
Current Drawdown Current decline from peak	-93.95%	-10.29%	-83.66%
Average Drawdown Average peak-to-trough decline	-40.28%	-10.73%	-29.55%
Ulcer Index Depth and duration of drawdowns from previous peaks	38.37%	8.68%	+29.69%

Volatility

QDEL vs. PB - Volatility Comparison

Quidel Corporation (QDEL) has a higher volatility of 35.15% compared to Prosperity Bancshares, Inc. (PB) at 6.01%. This indicates that QDEL's price experiences larger fluctuations and is considered to be riskier than PB based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	QDEL	PB	Difference
Volatility (1M) Calculated over the trailing 1-month period	35.15%	6.01%	+29.14%
Volatility (6M) Calculated over the trailing 6-month period	71.49%	17.14%	+54.35%
Volatility (1Y) Calculated over the trailing 1-year period	85.29%	23.00%	+62.29%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	61.98%	25.38%	+36.60%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	58.72%	30.43%	+28.29%

Dividends

QDEL vs. PB - Dividend Comparison

QDEL has not paid dividends to shareholders, while PB's dividend yield for the trailing twelve months is around 3.31%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PB Prosperity Bancshares, Inc.	3.31%	3.39%	3.00%	3.26%	2.90%	2.75%	2.70%	2.35%	2.39%	1.97%	1.73%	2.33%
QDEL Quidel Corporation	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

Frequently Asked Questions

Can I hold both QDEL and PB in my portfolio?

QDEL and PB have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, QDEL or PB?

QDEL has higher volatility (35.15%) compared to PB (6.01%). In terms of maximum drawdown, QDEL dropped -96.70% vs PB's -47.89%.

Which has better risk-adjusted returns?

PB currently has the higher Sharpe Ratio (-0.01 vs -0.49), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.